A.Vogel Passiflora Complex drops - with Passion Flower Extract - 50ml

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Gow PJ, Connelly NJ, Crowley P, Angus PW, Hill RL. Fatal fulminant hepatic failure induced by a natural therapy containing kava. Medical Journal of Australia. 2003;178(9):442-443. doi:10.5694/j.1326-5377.2003.tb05286.x Benzodiazepines: Passion flower may enhance the adverse/toxic effect of benzodiazepines. Monitor therapy.( Akhondzadeh 2001, Appel 2011, Carrasco 2009, Khom 2007) Adverse Reactions Heart failure. Early research shows that taking a combination of passion flower and hawthorn by mouth for 6 weeks increases six-minute walking distance but not exercise capacity during a bicycle exercise in people with mild heart failure. Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018;36:30-32. doi:10.1016/j.ctim.2017.11.008

From 2006 to 2013, 27 traditional herbal products containing Passiflora were registered with the Medicines and Healthcare Products Regulatory Agency (MHRA) of the United Kingdom. All of them contain extracts of P. incarnata in single formulations or in association with other plant species. These associations represent approximately 74% of all the products, and include, in their formulations, species traditionally used to treat anxiety, such as Valeriana officinalis (Valerianaceae), Lactuca virosa (Asteraceae), Hypericum perforatum (Hypericaceae), and Melissa officinalis (Lamiaceae) [ 20]. The alkaloids in passion flower also may prevent the production of monoamine oxidase, which is exactly what anti-depressant medication tries to do. Studies have shown that it may reduce depression, a common problem for women in menopause, including research conducted on animal models. Anxiety Symptoms - Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. (2001-Oct) Reducing anxiety. Passionflower is used in medicine for its anxiolytic ability that may stem from its abundance of active flavonoids, including apigenin.Miroddi M, Calapai G, et al. Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. J Ethnopharmacol. 2013 Dec 12;150(3):791-804. ↩ In one study, P. incarnata extract exerted antiparkinsonian effects and enhanced cognitive activity in mice.( Ingale 2017) In another study, 5 different extracts of P. incarnata were studied, and 2 were found to exert antiepileptic activity in an animal model of PTX-induced seizures. All 5 extracts increased, rather than decreased, anxiety levels.( Elsas 2010) Anticonvulsant activity in mice has been reported in other studies.( Nassiri-Asl 2007, Singh 2012) Passiflora incarnata. Photo by: Oliver P. Quillia} (Own work) [ CC BY 3.0], via Wikimedia CommonsPassionflower, Passiflora, includes more than 500 species of herbs bearing gorgeous flowers. The maypop or purple passionflower, in particular, stands out for its health benefits with such potential uses in sleep as: Hamid HA, Ramli AN, Yusoff MM Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review. Front Pharmacol. (2017) Meier S, Haschke M, Zahner C, et al. Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study. Phytomedicine. 2018 Jan 15;39:85-92. View abstract.

Medina JH, Paladini AC, et al. Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol. 1990 Nov 15;40(10):2227-31. ↩ Dos Reis Izolan L, da Silva DM, Oliveira HBL, et al. Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice. Neurochem Res. 2021. View abstract.Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. View abstract. Information is limited and cannot be extrapolated from one species to another. Passion flower has "generally recognized as safe" (GRAS) status according to the US Food and Drug Administration (FDA). Certain Passiflora species are reported to exhibit genotoxicity and to contain cyanogenic constituents, and are also associated with hepatobiliary and pancreatic toxicity. Scientific Family Animal studies that have been published indicating passion flower fruit pulp as a potential remedy for reducing systolic blood pressure by administering eight milligrams of passion flower for a period of five days. The results indicated that passion flower extract increased levels of an antioxidant enzyme and decreased levels of oxidized lipids that can cause damage from the accumulation of toxins and waste products in the body. 3. Can Reduce Anxiety