Fenbendazole 222mg, Purity >99%, by Fenben Lab, Certified Third-Party Laboratory Tested, Analysis Report Included, 30 capsules

Product Information

According to a 2018 study, Fenbendazole (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl) carbamate) is a broad-spectrum benzimidazole anthelminthic approved for use in numerous animal species. Repurposing of veterinary drugs showing promising results for human use can result in considerable time and cost reduction required to develop new drugs. Fenbendazole is known to have a high safety margin and most species tolerate it very well. It has very low degree of toxicity and high degree of safety in experimental animals.

Due to its antioxidant, anti-tumor, and anti-inflammatory activity, quercetin has been studied extensively. Quercetin can inhibit the spread of many cancers, such as prostate, cervical, lung, breast, and colon. Quercetin is not harmful to healthy cells yet powerful against cancer cells, making it a good candidate for a supplementary factor along with other anticancer medications.

PRODUCT DATA SHEETS AND BROCHURE

I have been on Zytiga along with ADT Zolodex for 27 months. Fenbendazole but more likely Mebendazole (OTC in Mexico, I’m in Canada) is on my radar when my PSA goes up from 0.01 to over 1. But I’m not as excited about this as Lu177 which I hope will be approved in US and Canada in 2021 before my PSA starts a fast rise. I've cut out almost all refined sugar and eat whole grain sourdough breads. My meals consist of fruits, vegetables and legumes for the most part. I do have Tuna, Salmon and other fish about once a week. Fenbendazole was dissolved in sterile, pyrogen-free physiologic saline and injected i.p.. Mice to be irradiated were anesthetized using 100 mg/kg of ketamine plus 10 mg/kg xylazine and tumors were irradiated locally with 10 Gy of 250 kV x-rays from a Siemens Stabilipan (Malvern, PA, USA) delivered at 15 mA, 2 mm Al filtration and a dose rate of 6.4 Gy per minute, as described previously ( 8– 10). The bodies and limbs of the mice were shielded so that the dose to critical normal tissues was less than 0.5 Gy and did not cause significant injury. Stopping tubulin polymerization into microtubules via benzimidazole carbamates in the helminths as well as in human tumor cells has been well verified. ( Ref.1 , Ref.2)

Some common side effects that have been reported include elevated liver enzymes, mild diarrhea, and mild stomach discomfort. In practice, drug companies often find ways to extend their patent or to extend their control even without a patent, for example by paying off generic drug manufacturers to leave their drug alone. EMT6 cells harvested from exponentially growing monolayers were plated into Petri dishes or glass culture flasks containing Waymouth’s medium supplemented with 15% serum (FetalPlex ™) and antibiotics (all from Invitrogen, Carlsbad, CA, USA) ( 8– 10). Cultures were incubated at 37°C in a humid atmosphere of 95% air/5% CO 2 for three days and were in the middle of exponential growth at the time of treatment. Cell viability was assayed by trypsinizing and suspending the cells at the end of the treatment, counting the cells with a Coulter counter, and assaying the abilities of the cells to form colonies in cell culture as described in detail previously ( 4, 7– 9). Surviving fractions were calculated by comparing the clonogenicity of treated cells with those of untreated control cells plated on the same day. If the numbers of cells in treated and control cultures differed, cell viability was also assessed using yield-corrected surviving fractions, which consider both the difference in cell number and the difference in clonogenicity ( 9). Data shown on the graphs are geometric means±SEM from multiple independent experiments. Because some treatment agents used in these experiments are quite effective in killing tumor cells, the surviving fractions in these experiments spanned a wide range (from 1.0 to 0.02); the survival curves are therefore plotted using logarithmic Y axes to allow for rigorous comparison of the data over the full range of the observed survivals. Wei L, Dai Q, Zhou Y, Zou M, Li Z, Lu N, Guo Q. Wei L, et al. Biochim Biophys Acta. 2013 Jun;1830(6):3835-45. doi: 10.1016/j.bbagen.2013.03.009. Epub 2013 Mar 15. Biochim Biophys Acta. 2013. PMID: 23500080

Final Note

Unlike most experimental treatments, this one seems to be an already approved drug that has been used for years - though I do see that there are potentially serious side effects. There is info about side effects in the FDA drug label. Fenbendazole is a benzimidazole, a class of microtubule-destabilizing agents. Other benzimidazoles, including albendazole, parbendazole, mebendazole and flubendazole have already been shown to have promising results in humans. While there have been very few scientific studies done on the possible cancer fighting benefits of fenbendazole, one such study suggests that fenbendazole has “been safely utilized as an anti-parasitic for various different animal species and could be repurposed for treating human malignancies.” Finally, there are many who are critics and are wary of Fenben saying there are no clinical studies on it etc. Well here's one from 2011. This study was conducted at the Department of Pathology, University of Southern California, Los Angeles, CA, USA. and the Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA. and was supported by NIH grant No. RO1 CA59705. Under typical circumstances, unadulterated fenbendazole is available in a powder format, and is a whitish hue with weak water solubility.