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Inclusion criteria were a 3-month history of the condition, age between 15 and 50, and the absence of risk factors including pregnancy, renal failure, uremia, diabetes, multiple sclerosis, and anemia.Calcium helps to initiate muscle contraction by interacting with the proteins that make up the muscle fibres. Please consult a healthcare practitioner before making changes to your diet or taking supplements that may interfere with medications.
Magnesium may have a role in the pathophysiology of RLS/WED since investigations have revealed that magnesium levels in the blood of RLS/WED patients are lower than those of controls. Magnesium sulfate can be administered via IV, though the oral supplement would likely be used instead for treating RLS.So it's not surprising that low levels of magnesium can lead to problems with muscle control, like the twitching and cramping associated with RLS. One trial published in 2022 gave 75 people with RLS daily doses of either magnesium, vitamin B6, or a placebo. The jury’s still out on transdermal magnesium (absorbable through the skin), with some anecdotal evidence touting the benefits of magnesium cream.