Cats: 1

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Willman, Chris (15 November 2019). "Taylor Swift Releases 'Beautiful Ghosts,' Her Andrew Lloyd Webber Collaboration for 'Cats' ". Variety. Archived from the original on 15 November 2019 . Retrieved 15 November 2019. Spycher M, Bauer A, Jagannathan V, Frizzi M, De Lucia M, Leeb T. A frameshift variant in the COL5A1 gene in a cat with Ehlers-Danlos syndrome. Anim Genet. 2018;49(6):641–4. Epub 2018/09/25. pmid:30246406. Universal Pictures (18 July 2019). CATS – Official Trailer [HD]. Archived from the original on 19 July 2019 . Retrieved 19 July 2019. Chang, Justin (18 December 2019). "Review: 'Cats' is a horror — and an occasional hoot". Los Angeles Times. Archived from the original on 19 December 2019 . Retrieved 19 December 2019. Competing interests: The authors disclose there are no conflicts of interest. The funders had no role in study design, data collection, data analysis, interpretation of results, or decision to publish.

Rosky, Nicole (1 November 2018). "Royal Ballet Principal Francesca Hayward Joins CATS Film as Victoria!". BroadwayWorld.com. Archived from the original on 1 April 2019 . Retrieved 4 March 2019. Wang P, Mazrier H, Caverly Rae J, Raj K, Giger U. A GNPTAB nonsense variant is associated with feline mucolipidosis II (I-cell disease). BMC Vet Res. 2018;14(1):416. Epub 2018/12/29. pmid:30591066; PubMed Central PMCID: PMC6307278. Choi JW, Chung WH, Lee KT, Cho ES, Lee SW, Choi BH, et al. Whole-genome resequencing analyses of five pig breeds, including Korean wild and native, and three European origin breeds. DNA Res. 2015;22(4):259–67. Epub 2015/06/29. pmid:26117497; PubMed Central PMCID: PMC4535618. Jagannathan V, Gerber V, Rieder S, Tetens J, Thaller G, Drogemuller C, et al. Comprehensive characterization of horse genome variation by whole-genome sequencing of 88 horses. Anim Genet. 2019;50(1):74–7. Epub 2018/12/14. pmid:30525216. Montague MJ, Li G, Gandolfi B, Khan R, Aken BL, Searle SM, et al. Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication. Proc Natl Acad Sci U S A. 2014;111(48):17230–5. pmid:25385592; PubMed Central PMCID: PMC4260561.Desta, Yohana (19 October 2018). "Dame Judi Dench Is also Lending Her Presence to the Cats Movie Musical". Vanity Fair. Presented here is the first comprehensive genome-wide SV analysis for Felis_catus_9.0. Previous genome-wide SV analyses in the cat were performed in Felis_catus-6.2 and focused solely on copy number variation (CNV) [ 24]. Approximately 39,955 insertions, 123,731 deletions, 35,427 inversions, and 9,022 duplications were identified, far exceeding previous CNV calculations of 521 losses and 68 gains. This large discrepancy is likely due to a number of reasons including filtering stringency, sensitivity, and reference contiguity, where increased numbers of assembly gaps in previous reference genome assemblies hindered detection of larger SV events. An important difference regarding filtering stringency and sensitivity is that the average CNV length was 37.4 kb as compared to 2.7 kb for SVs in Felis_catus_9.0. Since CNV detection depends on read-depth [ 72, 73], only larger CNVs can be accurately identified, as coverage at small window sizes can be highly variable. The use of both split-read and read-pair information [ 74, 75], allowed the identification of SV events at much finer resolution than read-depth based tools [ 76]. D'Alessandro, Anthony (26 September 2018). " 'Cats': Dancer Mette Towley Joins Cast Of Universal-Working Title Film". Deadline. Archived from the original on 26 September 2018 . Retrieved 21 February 2019. Cats (2019)". Rotten Tomatoes. Fandango Media. Archived from the original on 14 January 2020 . Retrieved 10 October 2021. Xue C, Raveendran M, Harris RA, Fawcett GL, Liu X, White S, et al. The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences. Genome Res. 2016;26(12):1651–62. Epub 2016/12/10. pmid:27934697; PubMed Central PMCID: PMC5131817.

Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 2016;536(7616):285–91. Epub 2016/08/19. pmid:27535533; PubMed Central PMCID: PMC5018207. a b Debruge, Peter (19 December 2019). " 'Cats': Film Review". Variety. Archived from the original on 19 December 2019 . Retrieved 22 December 2019. An important concern with using human constraint metrics for identifying causative variants in cats is the potential for false positives. For example, out of 16 SNVs initially identified as potential feline disease candidates, many belonged to cats with no recorded disease status ( S7 Table). However, since a large fraction of healthy humans also carried SNVs matching similar disease causing criteria as used in cats [ 58], evolutionary distance between humans and cats is unlikely to be a significant contributing factor to false positive candidate disease variant identification. Instead, the frequency of high impact variants in constrained genes is likely due to the limited resolution provided by analyses at the gene level. Recent strategies in humans have confronted this problem by focusing on constraint at the level of gene region. These analyses identified many genes with low pLI values that contained highly constrained gene regions that were also enriched for disease causing variants [ 71]. Alternatively, another strategy for further refining constrained regions could involve combining genomic variation from multiple species. Many variants observed in cats, along with their impact on genes, are likely unique to cats and could potentially be applied to variant prioritization workflows in humans. Gudbjartsson DF, Helgason H, Gudjonsson SA, Zink F, Oddson A, Gylfason A, et al. Large-scale whole-genome sequencing of the Icelandic population. Nat Genet. 2015;47(5):435–44. Epub 2015/03/26. pmid:25807286.Burlingame, Jon (24 October 2019). "Taylor Swift and Andrew Lloyd Webber Have Co-Written a New Song for 'Cats' ". Variety. Archived from the original on 25 October 2019 . Retrieved 25 October 2019. D'Alessandro, Anthony (8 November 2018). " 'Cats' Cast: Royal Ballet Principal Dancer Steven McRae To Play Skimbleshanks". Archived from the original on 8 November 2018 . Retrieved 8 November 2018. Macavity: The Mystery Cat" – Bombalurina, Macavity, Mungojerrie, Rumpleteazer, Griddlebone & Company McNary, Dave (6 May 2016). "Tom Hooper to Direct 'Cats' Movie for Universal". Variety. Archived from the original on 23 December 2017 . Retrieved 21 February 2019.

D'Alessandro, Anthony (19 November 2018). "Rebel Wilson To Play Jennyanydots In Universal-Working Title's 'Cats' ". Archived from the original on 19 November 2018 . Retrieved 19 November 2018.

Figures

Gabor L, Malik R, Canfield P. Clinical and anatomical features of lymphosarcoma in 118 cats. Australian Veterinary Journal. 1998;76(11):725–32. pmid:9862061

Department of Hepatogastroenterology and Centre d'Investigation Clinique, Huriez Hospital, Lille, France. ThatHashTagShow (13 June 2018). "EXCLUSIVE: Anne Hathaway In Talks To Star In Universal's CATS". That Hashtag Show. Archived from the original on 17 November 2018 . Retrieved 21 February 2019.

Driscoll CA, Menotti-Raymond M, Roca AL, Hupe K, Johnson WE, Geffen E, et al. The Near Eastern origin of cat domestication. Science. 2007;317(5837):519–23. Epub 2007/06/30. pmid:17600185; PubMed Central PMCID: PMC5612713. The merging of the two independent SV call sets was performed across all individuals for variants occurring within 50 bp of the independent variant call position, with agreement on variant type and strand, and variant size within 500 bp. Per cat, an average of 44,990 SVs were identified, with variants encompassing 134.3 Mb across all individuals. Deletions averaged 905 bp, duplications 7,497 bp, insertions 30 bp, and inversions 10,993 bp. The breed and breed crosses (n = 36) compared to random bred cats (n = 18) showed comparable SV diversity (t-test p = 0.6) ( S6 Fig). In total, 208,135 SVs were discovered, of which 123,731 (60%) were deletions ( Fig 3A). SV population frequencies were similar across SV types, except for inversions. For deletions, duplications and insertions, 38% to 48% of each SV type was found at population frequencies of 0.02–0.10 and 0.10–0.50. Meanwhile, > 90% of inversions are found at a population frequency of 0.02–0.10 ( Fig 3A). The majority of SVs identified are common across cats, suggesting their impacts are mostly tolerated. Andrew Lloyd Webber warned Universal bosses Cats movie would be 'a car crash' ". Film-News.co.uk. 9 June 2021. Abyzov A, Urban AE, Snyder M, Gerstein M. CNVnator: an approach to discover, genotype, and characterize typical and atypical CNVs from family and population genome sequencing. Genome Res. 2011;21(6):974–84. Epub 2011/02/18. pmid:21324876; PubMed Central PMCID: PMC3106330. Setoodeh, Ramin (16 December 2019). "Taylor Swift Reveals How Her Dad Inspired a Psychedelic Scene in 'Cats' (EXCLUSIVE)". Variety. Archived from the original on 17 December 2019 . Retrieved 17 December 2019.