60 Billion CFU Probiotic Cultures - Scientifically Backed Lactospore® for Good Gut Flora - Enteric Coating to Ensure Probiotics are Delivered Directly to The Gut - Made in The UK

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Liu X, Mao B, Gu J, Wu J, Cui S, Wang G, et al. Blautia—a new functional genus with potential probiotic properties? Gut Microbes. 2021;13:1–21. Shi J, Luo D, Weng H, Zeng XT, Lin L, Chu H, et al. Optimally estimating the sample standard deviation from the five-number summary. Res Synth Methods. 2020;11:641–54.

Forssten S, Evans M, Wilson D, Ouwehand AC. Influence of a probiotic mixture on antibiotic induced microbiota disturbances. World J Gastroenterol. 2014;20:11878–85.The evidence is still accumulating, and more research is necessary to provide clear answers. However, probiotics appear to be helpful for IBS symptoms, such as: Lance GN, Williams WT. Computer programs for hierarchical polythetic classification (“similarity analyses”). Comput J. 1966;9:60–4. While we think of our digestive system mainly for its role in processing food and getting us the nutrients that we need, it is also one of the most active components of our immune system. Data suggest that probiotic bacteria directly and indirectly enhance a protective immune response.

Allocati N, Masulli M, Alexeyev MF, Di Ilio C. Escherichia coli in Europe: an overview. Int J Environ Res Public Health. 2013;10:6235–54. Nečekané změny hmotnosti (nebírání nebo úbytek váhy bez plánování může být příznakem nezdravých střev) Horii T, Suzuki S, Takano C, Shibuya H, Ichijima R, Kusano C, et al. Lower impact of vonoprazan–amoxicillin dual therapy on gut microbiota for Helicobacter pylori eradication. J Gastroenterol Hepatol. 2021;36:3314–21. Ginger root PE 4:1 (Zingiber officinale) Fennel seed extract 4:1 (Foeniculum vulgare) Artichoke leaf extract 4:1 (Cynara scolymus) Peppermint leaf powder (Mentha piperita) Ribeiro CFA, Silveira GGDOS, Cândido EDS, Cardoso MH, Espínola Carvalho CM, Franco OL. Effects of antibiotic treatment on gut microbiota and how to overcome its negative impacts on human health. ACS Infect Dis. 2020;6:2544–59.Wang ZJ, Chen XF, Zhang ZX, Li YC, Deng J, Tu J, et al. Effects of anti-Helicobacter pylori concomitant therapy and probiotic supplementation on the throat and gut microbiota in humans. Microb Pathog. 2017;109:156–61. Our formula contains no genetically modified or pathogenic microorganisms. Each ingredient used to culture the microbes is 100% natural. By controlling our own manufacturing and maintaining rigorous quality control standards, we’re able to provide you with consistent, high-end probiotics every time! Long shelf-life

At phylum level, a decreasing trend in the proportion of Firmicutes and Bacteroidetes with a higher relative abundance of Proteobacteria was observed after antibiotic therapy in both groups, regardless of probiotic supplementation. There was also a reduction in the Bacteroidetes:Firmicutes (B:F) ratio at the cessation of treatments. This was confirmed by several studies; however, in the study of Oh et al., the reduction was significantly greater in the control group [ 43, 52, 56]. Importantly, these changes in phyla abundances disappeared at day 56 in the studies of Chen et al. and Tang et al. [ 52, 64]. Zohre T-S, Imen S, Latifa B, Olivier L, Vincent M, Shao Bing F, et al. Roseburia spp.: a marker of health? Future Microbiol. 2017;12:157–70. Probiotics have also been shown to have an important impact on the absorption, use, and storage of energy from the food we consume, including the generation of beneficial short-chain fatty acids that promote weight regulation. Hanchi H, Mottawea W, Sebei K, Hammami R. The genus Enterococcus: between probiotic potential and safety concerns-an update. Front Microbiol. 2018;9:1–16. Although all the included studies were RCTs, the baseline values in the article by De Wolfe et al. [ 53] showed a marked difference between the probiotic and control groups (MD = 0.64 [(0.05 –1.22]). As a sensitivity analysis, we performed a separate calculation for data before the treatment and for the “before-after” values change in each study (Additional File 3: Fig. S1-2). We did not find any significant difference in the change values between the experimental and control groups regarding the Shannon diversity index (MD = 0.07 [(−)0.19 –0.32]). The impact of probiotic supplementation during antibiotic therapy on the Chao1 index

How we tested

Risk-of-bias assessment was performed by two independent authors using the revised Cochrane risk-of-bias tool (RoB2) [ 48]. Disagreements were solved by consensus. Domains assessed biases resulting from the randomization process, deviations from the intended intervention, missing data, the measurement of the outcome, and the selection of the reported results. The investigators rated each domain, and the risk level was automatically calculated by the algorithm, which could be characterized as low, some concerns, or high. Certainty assessment Probiotics are defined as microorganisms that provide benefits to their host. Humans rely on resident microorganisms, including probiotics, to keep our bodies healthy and functioning properly, but diet and other factors can alter our healthy bacteria 1*. Probiotics for Overall Gut Health Chen L, Xu W, He J, Lee A, Si J, Chen S. The impact of Helicobacter pylori infection, eradication therapy, and probiotic supplementation on gut microenvironment homeostasis: an open-label, prospective clinical trial. J Gastroenterol Hepatol. 2018;33:54–221. Inthout J, Ioannidis JP, Borm GF. The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method. BMC Med Res Methodol. 2014;14:1–12.

Cárdenas PA, Garcés D, Prado-Vivar B, Flores N, Fornasini M, Cohen H, et al. Effect of Saccharomyces boulardii CNCM I-745 as complementary treatment of Helicobacter pylori infection on gut microbiome. Eur J Clin Microbiol Infect Dis. 2020;39:1365–72.Probiotics are preparations containing live micro-organisms, typically composed of microbes that are also found in the natural gut flora. Probiotics may contain bacteria, yeasts, or a mixture of them [ 11]. These products are used to prevent dysbiosis; however, the effects of concurrent probiotic supplementation on fecal microbiota diversity and taxonomical composition during antibiotic therapy are not fully understood. The effects of these products on clinical outcomes during antibiotic therapy have been intensely researched; however, most research did not focus on investigating the composition of the gut microbiome. This aspect is also missing from the current guidelines on the use of probiotics of the American Gastroenterological Association (AGA) and World Gastroenterology Organization (WGO) [ 11, 12]. has a sufficient number of colony-forming units (CFUs), which indicates the number of viable bacteria per dose Rozwandowicz M, Brouwer MSM, Fischer J, Wagenaar JA, Gonzalez-Zorn B, Guerra B, et al. Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae. J Antimicrob Chemother. 2018;73:1121–37. Nesnášenlivost potravin (netolerance laktózy může být způsobena nízkou kvalitou bakterií ve střevech)