Activon Medical Grade Manuka Honey 25g (Pack of 3)

Product Information

Versatile Applications: Ideal for necrotic tissue and dressing top up. U seful for application into abscesses or cavity wounds. The manuka honey comes from New Zealand and is produced following strict quality management and control procedures that ensure the honey remains free from any contaminants. It is also tested to establish the antibacterial level of the manuka honey as a high level is required for medical grade manuka honey. Hydrogen peroxide activity. Honey contains an enzyme called oxidase. Its role is to break the glucose down into gluconic acid and hydrogen peroxide. Due to low pH, this doesn’t happen in pure honey, but when it is applied on a wound, the serum from the tissues dilute the honey and raises its pH, also adding sodium and activating the oxidase. Small quantities of hydrogen peroxide is produced little by little directly on the wound.

Here are the factors that turn honey into a healing medicine. (More details on how does honey act as antimicrobial here: How to kill antibiotic resistant bacteria) picture source: http://www.advancis.co.uk/products/activon-manuka-honey/activon-tube and http://www.advancis.co.uk/products/super-absorber-dressings/eclypse Most effective combination against established S. aureus biofilms was rifampicin and Medihoney. Fusidic acid and Medihoney combination induced some synergistic antimicrobial effects.Medical grade honey is manuka honey that has been was sterilized from all impurities and microorganisms (spores). Flexible Application Methods: Can be applied directly onto the wound itself or onto a gauze or foam dressing. When first applied, you may feel a discomfort and may need to take an analgesic. The initial discomfort usually subsides, however if it does continue, discontinue use and irrigate the wound with saline solution. Are these products complying with the regulations? Several researchers have explored the effects of combining honey with antibiotics on antimicrobial activity in vitro. One of the first papers reporting a synergistic effect of honey and antibiotics was published in 1998. The researchers used a broth dilution assay to demonstrate a synergistic effect of an Indian honey (obtained from Phondaghat Pharmacy) and the antibiotics amikacin, ceftazidime and gentamicin against multidrug-resistant clinical isolates of P. aeruginosa. 20 The honey and antibiotics were reportedly tested at a ratio of 1:1. Experiments were also conducted with Klebsiella species, but no synergy was observed with this micro-organism. Later in 2005, another study reported synergy using broth dilution method between an Omani honey (50%) and the antibiotic gentamicin (4µg/mL) against Staphylococcus aureus. 21 Additionally, a study conducted in Egypt reported enhanced effects of antibiotics against clinical isolates of P. aeruginosa, Enterobacter species and Staphylococci in a disc diffusion assay when citrus bee honey (100%) was added to the antibiotic discs (Oxoid). 22

Twist off the cap, generously apply to the wound surface or cavity, and cover with a suitable secondary dressing. Shelf Life The MIC of the combination of honey, cinnamaldehyde and carvacrol was lower than honey alone (0.49µg/mL vs 114.2 μg/mL respectively). The antibacterial activity of the triple combination was reportedly greater than imipenem.Although the honey is not absorbed into the blood stream, we advise monitoring the levels of patients with diabetes. Discomfort can be experienced when honey is applied, depending on sensitivity of the wound it may be necessary to consider an appropriate level of analgesia. The initial discomfort usually subsides, however if it does continue, discontinue use and irrigate the wound with saline solution. How to Use