Vitamin B3 Nicotinamide (Niacinamide) 500mg 180 Capsules (V) Vegan. No-Flush Niacinamide. Made in The UK by Health4All

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Thompson BC, Halliday GM, Damian DL. Nicotinamide enhances repair of arsenic and ultraviolet radiation-induced DNA damage in HaCaT keratinocytes and ex vivo human skin. PLoS One. 2015;10(2):e0117491. It’s been suggested that niacinamide protects and preserves the beta cells, thereby preventing or delaying the onset of type 1 diabetes in at-risk individuals ( 21, 22, 23). Winter SL, Boyer JL. Hepatic toxicity from large doses of vitamin B3 (nicotinamide). N Engl J Med. Nov 29 1973;289(22):1180-1182. Vitamin B3, in the form of nicotinic acid or niacinamide, is available as a supplement either by itself or alongside other vitamins and minerals in doses ranging from 14 to 1,000 mg per serving.

Niacinamide: Benefits, Uses and Side Effects - Healthline

In multiple clinical studies, topical nicotinamide improved fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing) as well as elasticity. One study showed nicotinamide to increase the skin's production of ceramides, which are natural emollients and skin protectants, thus improving skin hydration.

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Williams PA, Harder JM, Foxworth NE, et al. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science. Feb 17 2017;355(6326):756-760. Raines NH, Ganatra S, Nissaisorakarn P, et al. Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study. Kidney360 2020;2(1):33-41. View abstract. Another study of 30 healthy Japanese females reported improvement of eyelid wrinkles after eight weeks of application of a cosmetic containing 4% nicotinamide. Amengual JE, Clark-Garvey S, Kalac M, Scotto L, Marchi E, Neylon E, Johannet P, Wei Y, Zain J, O'Connor OA. Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma. Blood. 2013 Sep 19;122(12):2104-13. View abstract. Omidian M, Khazanee A, Yaghoobi R, Ghorbani AR, Pazyar N, Beladimousavi SS, Ghadimi M, Mohebbipour A, Feily A. Therapeutic effect of oral nicotinamide on refractory uremic pruritus: a randomized, double-blind study. Saudi J Kidney Dis Transpl. 2013 Sep;24(5):995-9. View abstract.

Randomized Trial of Nicotinamide for Skin-Cancer A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer

It can improve skin barrier function by decreasing water loss through the epidermis (the outer skin layer) thus increasing skin hydration. Placebo-controlled trials have suggested high-risk sun-damaged patients taking oral nicotinamidewho have extensive actinic keratoses and cutaneous squamous cell carcinomasmay expect a reduction in the number of new lesions over time. The evidence is inconclusive. Adverse effects of oral nicotinamide Nijkamp MM, Span PN, Terhaard CH, Doornaert PA, Langendijk JA, van den Ende PL, de Jong M, van der Kogel AJ, Bussink J, Kaanders JH. Epidermal growth factor receptor expression in laryngeal cancer predicts the effect of hypoxia modification as an additive to accelerated radiotherapy in a randomised controlled trial. Eur J Cancer. 2013 Oct;49(15):3202-9. View abstract.

How does nicotinamide work?

Zhang Y, Ma T, Zhang P. Efficacy and safety of nicotinamide on phosphorus metabolism in hemodialysis patients: A systematic review and meta-analysis. Medicine (Baltimore). 2018;97(41):e12731. doi:10.1097/MD.0000000000012731 Brooks-Hill RW, Bishop ME, Vellend H. Pellagra-like encephalopathy complicating a multiple drug regimen for the treatment of pulmonary infection due to Mycobacterium avium-intracellulare (letter). Am Rev Resp Dis 1985;131:476. View abstract. Powell ME, Hill SA, Saunders MI, Hoskin PJ, Chaplin DJ. Human tumor blood flow is enhanced by nicotinamide and carbogen breathing. Cancer Res. 1997;57(23):5261-4. View abstract.