MAGNE B6 MAX - 50 Capsules - is a Dietary Supplement containing in its Composition Magnesium and Vitamin B6, for People Suffering Weakness, Fatigue, Twitching eyelids and Muscle spasms

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Ahmad I, Mirza T, Qadeer K, Nazim U, Vaid FH (September 2013). "Vitamin B6: deficiency diseases and methods of analysis". Pak J Pharm Sci. 26 (5): 1057–69. PMID 24035968. Shimizu T (2001). "新しい保健機能性食晶制度の概要"[Newly Established Regulation: Foods with Health Claims] (PDF). Journal of the International Life Sciences Institute of Japan (in Japanese). 66: 9–15. According to a prospective cohort study the long-term use of vitamin B 6 from individual supplement sources at greater than 20mg per day, which is more than ten times the adult male RDA of 1.7mg/day, was associated with an increased risk for lung cancer among men. Smoking further elevated this risk. [59] However, a more recent review of this study suggested that a causal relationship between supplemental vitamin B 6 and an increased lung cancer risk cannot be confirmed yet. [60] a b Wang Y, Liu L, Jin Z, Zhang D (2021). "Microbial Cell Factories for Green Production of Vitamins". Front Bioeng Biotechnol. 9: 661562. doi: 10.3389/fbioe.2021.661562. PMC 8247775. PMID 34222212. Cooking, storage, and processing losses vary, and in some foods may be more than 50% depending on the form of vitamin present in the food. [3] Plant foods lose less during processing, as they contain pyridoxine, which is more stable than the pyridoxal or pyridoxamine forms found in animal-sourced foods. For example, milk can lose 30–70% of its vitamin B 6 content when dried. [15] The vitamin is found in the germ and aleurone layer of grains, so there is more in whole wheat bread compared to white bread wheat, and more in brown rice compared to white rice. [30]

As of 2019, fourteen countries require food fortification of wheat flour, maize flour or rice with vitamin B 6 as pyridoxine hydrochloride. Most of these are in southeast Africa or Central America. The amounts stipulated range from 3.0 to 6.5mg/kg. An additional seven countries, including India, have a voluntary fortification program. India stipulates 2.0mg/kg. [31] Dietary supplements [ edit ] Magne B6 Stop Stress 30 TabletsA powerful combination of golden root extract, vitamin B9, vitamin B6..A seven-year study in over 5,400 female health professionals found that taking a daily supplement of vitamin B6, B12 and folic acid (B9) significantly reduced AMD risk by 35–40%, compared to a placebo ( 43). Question 14—What are the standards and labeling criteria for Foods with Nutrient Function Claims?]. Ministry of Health, Labour, and Welfare (in Japanese) . Retrieved 2021-09-23. ビタミンＢ ６は、たんぱく質からのエネルギー産生と皮膚や粘膜の健康維持を助ける栄養素です。 Research on vitamin B6 and breast cancer also shows an association between adequate blood levels of B6 and a decreased risk of the disease, especially in postmenopausal women ( 37). More research that includes randomized trials and not merely observational studies is needed to assess the exact role of vitamin B6 in cancer prevention.

Brasky TM, White E, Chen CL (October 2017). "Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort". Journal of Clinical Oncology. 35 (30): 3440–3448. doi: 10.1200/JCO.2017.72.7735. ISSN 1527-7755. PMC 5648175. PMID 28829668. The assessment of vitamin B 6 status is essential, as the clinical signs and symptoms in less severe cases are not specific. [39] The three biochemical tests most widely used are plasma PLP concentrations, the activation coefficient for the erythrocyte enzyme aspartate aminotransferase, and the urinary excretion of vitamin B 6 degradation products, specifically urinary PA. Of these, plasma PLP is probably the best single measure, because it reflects tissue stores. Plasma PLP of less than 10nmol/L is indicative of vitamin B 6 deficiency. [38] A PLP concentration greater than 20nmol/L has been chosen as a level of adequacy for establishing Estimated Average Requirements and Recommended Daily Allowances in the USA. [4] Urinary PA is also an indicator of vitamin B 6 deficiency; levels of less than 3.0mmol/day is suggestive of vitamin B 6 deficiency. [38] Other methods of measurement, including UV spectrometric, spectrofluorimetric, mass spectrometric, thin-layer and high-performance liquid chromatographic, electrophoretic, electrochemical, and enzymatic, have been developed. [38] [40] One study in 156 adults with high homocysteine levels and mild cognitive impairment found that taking high doses of B6, B12 and folate (B9) decreased homocysteine and reduced wasting in some regions of the brain that are vulnerable to Alzheimer’s ( 16). Kobayashi D (2019). "[Food Poisoning by Ginkgo Seeds through Vitamin B6 Depletion]". Yakugaku Zasshi (in Japanese). 139 (1): 1–6. doi: 10.1248/yakushi.18-00136. PMID 30606915. Mei N, Guo X, Ren Z, Kobayashi D, Wada K, Guo L (January 2017). "Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports". J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 35 (1): 1–28. doi: 10.1080/10590501.2016.1278298. PMC 6373469. PMID 28055331.It’s needed for many processes in your body, including creating neurotransmitters and regulating homocysteine levels. a b c d "Vitamin B 6". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. May 2014. Archived from the original on 2018-03-14 . Retrieved 7 March 2017. The end-product of vitamin B 6 catabolism is 4-pyridoxic acid, which makes up about half of the B 6 compounds in urine. 4-Pyridoxic acid is formed by the action of aldehyde oxidase in the liver. Amounts excreted increase within 1–2 weeks with vitamin supplementation and decrease as rapidly after supplementation ceases. [4] [38] Other vitamin forms excreted in the urine include pyridoxal, pyridoxamine and pyridoxine, and their phosphates. When large doses of pyridoxine are given orally, the proportion of these other forms increases. A small amount of vitamin B 6 is also excreted in the feces. This may be a combination of unabsorbed vitamin and what was synthesized by large intestine microbiota. [4] Deficiency [ edit ] Signs and symptoms [ edit ]

However, vitamin B6 deficiency is thought to be rare in most healthy adults, so there is limited research on using B6 to treat anemia. Magnesium and vitamin B6 are said to be compatible with breastfeeding women. The recommended daily intake of vitamin B6 for lactating women is 20mg/day (equivalent to 4 tablets or 2 ampoules). Less severe cases present with metabolic disease associated with insufficient activity of the coenzyme pyridoxal 5’ phosphate (PLP). [1] The most prominent of the lesions is due to impaired tryptophan– niacin conversion. This can be detected based on urinary excretion of xanthurenic acid after an oral tryptophan load. Vitamin B 6 deficiency can also result in impaired transsulfuration of methionine to cysteine. The PLP-dependent transaminases and glycogen phosphorylase provide the vitamin with its role in gluconeogenesis, so deprivation of vitamin B 6 results in impaired glucose tolerance. [1] [15] Diagnosis [ edit ]This is partly because this vitamin is necessary for creating neurotransmitters that regulate emotions, including serotonin, dopamine and gamma-aminobutyric acid (GABA) ( 3, 4, 5).