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Berberine Extract 1000mg 30 Capsules Vegan Organic Capsules 100% Natural by Vytox. 1 Month Supply

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Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide ( Huang et al., 2021). Studies indicate that the abnormal proliferation of vascular smooth muscle cells (VSMCs) is involved in the pathogenesis of CVD ( Xiang et al., 2020; Zhang et al., 2021a). It has also been demonstrated that berberine (10, 30 and 100μmol/L) could inhibit angiotensin IV-induced proliferation in cultured VSMCs by targeting the peroxisome proliferator-activated receptor α (PPAR-α)–nitric oxide (NO) signaling pathway ( Qiu et al., 2017). Myocardial Ischemia An epidemiological investigation showed that the incidence of hypertension increases with age across all countries, regions, or ethnicities, and is generally higher in industrialized countries than developing countries ( Zhou et al., 2021). Hypertension is more common in the elderly, and mostly manifests as simple systolic hypertension; however, it is increasing in younger age groups ( James et al., 2014; Zhang and Moran, 2017). Among the many mechanisms underlying arterial stiffness, endothelial dysfunction is believed to be a critical determinant for its onset and progression ( Kostov and Halacheva, 2018; Safar, 2018). Owing to arterial stiffness, elevated arterial blood pressure can contribute to both extracellular matrix (ECM) deposition and remodeling or enhanced contractility or stiffness of VSMCs ( Bertorello et al., 2015). In vitro, berberine (at concentrations of 1.25, 2.5, and 5μM) considerably inhibited aortic endothelial cells in spontaneous hypertensive rats (SHRs) by suppressing cell proliferation, apoptosis, and down-regulating the expression of Toll-like receptor 4 (TLR-4), myeloid differentiation protein 88 (MYD-88), NF-κB, IL-6, and TNF-α ( Wang and Ding, 2015). Numerous studies have verified that vascular endothelial cell dysfunction and lncRNA activity may together be associated with hypertension ( Lorenzen and Thum, 2016; Konukoglu and Uzun, 2017). The levels of five lncRNAs were found to be modulated by the administration of 100mg/kg berberine in mice with hypertention, which may preserve vascular endothelial cell function ( Tan et al., 2021). Endothelial microparticles (EMPs) are extracellular vesicles that are shed by the endothelium as a result of activation, injury, or apoptosis of endothelial cells, and are considered important biomarkers of the status of endothelial cells and vascular function ( Sun et al., 2016). Endothelial progenitor cells (EPCs) mobilized from bone marrow can migrate to the peripheral blood and differentiate into mature endothelial cells, contributing to endothelial recovery ( Pyšná et al., 2019). One study found that EPC number and activity was significantly reduced among people with hypertension when compared to healthy individuals, and low circulating levels of EPCs may contribute to endothelial dysfunction ( Waclawovsky et al., 2021). Abnormal circulating EMPs and EPCs in SHRs were ameliorated by berberine treatment associated with endothelial dysfunction and arterial stiffness in SHRs ( Zhang et al., 2020). Moreover, the production of NO caused by oxidative stress, aging, and spontaneous hypertension increases endothelium-dependent contractions (EDCs), contributing to blunted endothelium-dependent vasodilation ( Vanhoutte et al., 2005; Vanhoutte et al., 2017). Continuous ER stress can exert detrimental effects through a maladaptive, unfolded protein response, resulting in cellular defects and disturbed vascular function ( Ren et al., 2021). However, incubation with 1μM berberine has been shown to reduce EDCs by activating the AMPK pathway, thus inhibiting ER stress and ROS generation, leading to cyclo-oxygenase 2 (COX-2) downregulation in SHR carotid arteries ( Liu et al., 2015). However, recent studies on the distribution of berberine in vivo are rare, which may be attributed to the broad tissue distribution in vivo after oral administration. The availability of new technologies such as component analysis by high-performance liquid chromatography electrospray ionization mass spectrometry (HPLC–ESIMS)/mass spectrometry (MS) and MS imaging may permit improved exploration of the berberine tissue distribution ( Jove et al., 2019). The fact that berberine is widely distributed in tissues may be useful in the treatment of some diseases, which may broaden the scope of its clinical application. For example, with the character of enrichment in the liver, oral treatment with 100mg/kg berberine may promote the excretion of cholesterol from the liver to the bile ( Li et al., 2015b). Thus, distribution of berberine may be an important pharmacokinetic property requiring further study in future. Metabolism

Berberine Supplements of 2023 - The Nutrition Insider The 6 Best Berberine Supplements of 2023 - The Nutrition Insider

In a 2008 study of 116 people with diabetes, taking 1 gram of berberine per day lowered fasting blood sugar by 20% ( 11). Zhang, X., et al. (2015). Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. However, it is important to remember that researchers have only studied berberine’s effects on cancer cells in a laboratory, not in people. Gut health Vascular dementia (VD) is the second most common form of dementia and is caused by vascular pathologies causing brain injury ( Poh et al., 2021). In a rat model of VD induced by cerebral ischemia–reperfusion injury, increased angiogenesis was observed with berberine chloride (50mg/kg) treatment, which may be due to the activation of hypoxia-inducible factor 1α (HIF-1α)/VEGF signal pathway ( Liu et al., 2018). In general, few studies have focused on the relationship between berberine and vascular in VD. According to the development of new biological in recent years, imaging technology is conducive to strengthen the study of berberine and cerebrovascular diseases. Second near-infrared II (NIR-II) imaging, a kind of biomedical imaging technology with characteristics of high sensitivity, high resolution, and real-time imaging, can visualize the vasculature in the brain ( Guo et al., 2019a). Therefore, we can directly utilize the NIR-II to observe the improvement of the vascular in the brain by treatment with berberine. Hypertension If berberine can help treat cancer, inflammation, diabetes, and other conditions, it may be because of a beneficial effect on gut microbiota, according to some research published in 2020. Scientists have found links between the gut microbiome — colonies of bacteria in the gut — and these conditions.Lee, Y. S., et al. (2006). Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. High levels of low-density lipoprotein (LDL) cholesterol and triglycerides may increase the risk of heart disease and stroke. Li, M.-F., et al. (2018). The effect of berberine on polycystic ovary syndrome patients with insulin resistance (PCOS-IR): A meta-analysis and systematic review. It may also reduce high cholesterol and lipid levels and support liver function, brain health, and weight loss. Top Health Benefits of Berberine Xiaopeng Ai 1,2 Peiling Yu 2 Lixia Peng 1 Liuling Luo 1 Jia Liu 3 Shengqian Li 2 Xianrong Lai 1,3 Fei Luan 1* Xianli Meng 1,4*

Preparation and Evaluation of Antidiabetic Agents of - PubMed Preparation and Evaluation of Antidiabetic Agents of - PubMed

The 500mg dosage in Charava Berberine aligns to the researched dosage shown to support a healthy blood glucose response with each meal, among other benefits. One review reported that people who took 750 milligrams (mg) of barberry twice a day for 3 months had a significant decrease in weight. Barberry is a plant that contains high amounts of berberine. This work was supported by the National Natural Science Foundation of China (82004058 and 81774007), the National Key R&D Program of China (2017YFC1703904), the Regional Innovation and Cooperation Project of the Science and Technology Department of Sichuan Province (2020YFQ0032), the Major Science and Technology Project of Sichuan Science and Technology Department (2019YFSY0046), and the Key R&D and Transformation Program of the Science and Technology Department of Qinghai Province (2020-SF-C33). Conflict of InterestBacteria in the gut can decompose and metabolize berberine into dihydroberberine, thus preventing the absorption of disaccharides in the intestinal tract ( Feng etal., 2015), and increasing the secretion of GLP-1 and GLP-2 to protect pancreatic islet cells and reduce the levels of glucose in the blood ( Wei etal., 2014). Furthermore, berberine is able to regulate the expression of a range of related molecules in rats with DM, including the TLR4/MyD88/NF-κB signaling pathway ( Gong etal., 2017). In the rat model of T2DM, the bioavailability of berberine is higher than that in normal rats. Furthermore, compared with berberine hydrochloride, berberine organic acid salts (especially BF and berberine succinate) can not only control the levels of blood sugar and avert the occurrence of hyperchloremia, but can also significantly improve the oral bioavailability of berberine ( Cui etal., 2018b). Many studies show that berberine can significantly lower blood sugar levels in people with type 2 diabetes ( 8). Berberine has an antibacterial action that seems to remove the harmful bacteria in the gut, and thus enhance the growth of healthy bacteria. Asbaghi, O., et al. (2020). The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials [Abstract]. A systematic review found that berberine has promise as a treatment for PCOS with insulin resistance. However, the authors state that confirming these effects will require further studies. Cancer

Berberine Extract 1000mg 60 Capsules Vegan Organic Capsules Berberine Extract 1000mg 60 Capsules Vegan Organic Capsules

Elevated blood sugar levels characterize conditions like diabetes and prediabetes due to either decreased insulin production or decreased sensitivity to insulin. Lowers Blood Sugar. One of the top ways that berberine benefits health is through its ability to manage high blood glucose and insulin resistance—two of the leading risk factors for type 2 diabetes. Berberine activates the AMPK pathway to pull glucose from the blood, directly lowering blood sugar. Some research suggests that berberine works similarly to the drug metformin, which doctors often prescribe to treat type 2 diabetes. In fact, berberine may have the ability to change the bacteria in the gut, which could help treat both obesity and diabetes. Polycystic ovary syndromeBerberine appears to activate AMP-activated protein kinase, which can help regulate how the body uses blood sugar. Researchers believe this activation can help treat diabetes and related health issues, such as obesity and high cholesterol. This berberine supplement might not be for everyone, as these higher doses are more likely to cause digestive-related side effects when taken all at once. As berberine is a more natural way to support blood glucose, many are now searching for the best berberine supplements—and we’ve got you covered. Any questions you may have concerning your use of medications or supplements should be directed to your healthcare provider.

Berberine on the Gastrointestinal Microbiota - PMC Effects of Berberine on the Gastrointestinal Microbiota - PMC

Oxidative stress and inflammation: It has been shown to have potent antioxidant and anti-inflammatory effects in some test-tube and animal studies ( 25, 26, 27).

The Effects of Berberine on Obesity

A decent amount of animal research suggests berberine may help lower blood sugar levels via various pathways, including by the following ( 6, 7): Berberine could be an effective antimicrobial agent. A 2022 study found that berberine helped inhibit the growth of Staphylococcus aureus.

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