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Forman JP, Rimm EB, Stampfer MJ, Curhan GC. Folate intake and the risk of incident hypertension among US women. JAMA. 2005 Jan 19;293(3):320-9. Forman JP, Stampfer MJ, Curhan GC. Diet and lifestyle risk factors associated with incident hypertension in women. JAMA. 2009 Jul 22;302(4):401-11. Supplements that are third-party tested are sent to a lab where they are tested to ensure they contain what they say they contain and are not contaminated with specific high-risk, common contaminants. However, it’s important to note:
Dark green leafy vegetables (turnip greens, spinach, romaine lettuce, asparagus, Brussels sprouts, broccoli) He K, Merchant A, Rimm EB, Rosner BA, Stampfer MJ, Willett WC, Ascherio A. Folate, vitamin B6, and B12 intakes in relation to risk of stroke among men. Stroke. 2004 Jan 1;35(1):169-74.
help your baby's brain, skull and spinal cord develop properly in pregnancy, to avoid development problems (called neural tube defects) such as spina bifida Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease. New England Journal of Medicine. 2006 Apr 13;354(15):1567-77.
Nutrition C for FS and A. Questions and answers on dietary supplements. FDA. Published online October 26, 2022. To evaluate the effect of FA and 5-Me-THF on cells with diverse MTHFR activity, LCLs were segregated into two groups according to the predicted MTHFR activity based on the MTHFR genotype: (1) the normal MTHFR activity cell (>60% enzyme activity) group, which included genotype combinations 677CC/1298AA, 677CT/1298AA, 677CC/1298AC, and 677CC/1298CC; and (2) the low MTHFR activity cell (≤60% enzyme activity) group, which included genotype combinations 677CT/1298AC and 677TT/1298AA. To avoid the effect of RFC, cells with the mutated form of RFC were excluded from further analysis.
If you take too much
If you have a higher chance of having a baby with a neural tube defect your doctor will recommended an increased dose of 5mg, taken once a day. Dose for treating folate deficiency anaemia Mazza et al demonstrated the capacity of 400 μg of Quatrefolic, in conjunction with B6 and B12, to lower Hcy serum levels better than conventional vitamin supplementation with highly dosed folic acid (5 mg/day). Quatrefolic was tested on hypertensive people with a low cardiovascular risk—104 patients with HCys of ≥15 μmol/L. Vitamin B12 and folate perform several important functions in the body, including keeping the nervous system healthy. Many studies have reported that hyperhomocysteinemia was associated with numerous pregnancy complications, including recurrent pregnancy loss, 30 NTDs, 31 preeclampsia, 32 preterm delivery, 33 placental abruption, 34, 35 fetal growth restriction,36 and gestational diabetes mellitus. 37 Cawley et al also observed that neonatal birth weight and maternal Hcy levels were negatively correlated. 38 While the beneficial effects of folate supplementation in reduction of the risks of NTDs have been clearly demonstrated, 39-41 more robust meta-analyses are needed to assess its efficacy in preventing other congenital disabilities. 42-44
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