BiOptimizers Magnesium Breakthrough Supplement 4.0 - Has 7 Forms of Magnesium: Glycinate, Malate, Citrate, and More - Natural Sleep and Brain Supplement - 60 Capsules

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Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169 This interaction mainly occurs within the gastrointestinal tract. When oxalates and magnesium bind tightly to each other, creating magnesium oxalate, the magnesium becomes unable to dissolve. Consequently, a significant portion of magnesium oxalate passes through the digestive system without being absorbed. Magnesium is essential for converting the inactive thyroid hormone (T4) into its active form (T3). Without this conversion, your thyroid won’t function properly. Since T3 affects every cell and organ in your body, adequate magnesium is vital for optimal thyroid function. On the contrary, magnesium levels inside cells, such as RBC magnesium, are more indicative of your overall magnesium status. These intracellular levels are a better representation of your total magnesium status in the body.

Serum magnesium levels do not accurately reflect whole-body magnesium status. In certain instances, elevated serum magnesium may indicate the need for magnesium supplementation to be beneficial. Consequently, a comprehensive assessment of magnesium status should include tests for intracellular magnesium levels, consideration of symptoms and evaluation of medical history. As magnesium supports the brain and cardiac functions, it also strengthens the bones and muscles that keep the immune system strong. Magnesium is also considered to be a hormone regulator as low levels of this can contribute to menopausal symptoms.One study which followed more than 4,000 people for 20 years found that those with the highest magnesium intake were 47% less likely to develop diabetes

Reddy P, Edwards LR. Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019;26(1):e124-e132. doi:10.1097/MJT.0000000000000538 A meta-analysis of 34 randomized control trials found that magnesium reduced blood pressure. However, the effect size is clinically small (<2 mmHg). Therefore, it may be good for supporting overall health and healthy blood pressure, but you may also need other interventions to achieve healthy blood pressure levels. Athletes who supplemented with magnesium for four weeks had faster running, cycling and swimming times during a triathlon. They also experienced reductions in insulin and stress hormone levels

Insulin, a hormone secreted by the pancreas in response to blood sugar levels, is regulated by magnesium. Magnesium plays a crucial role in controlling the release of insulin and maintaining blood sugar regulation. It is instrumental in keeping your body sensitive to insulin and preventing insulin resistance.

A magnesium supplement significantly improved mood after 2 weeks. Another trial found that magnesium supplements improved mood in seniors. Animals were divided into groups receiving either a standard or high-protein diet with equivalent magnesium content. The high-protein diet yielded higher apparent magnesium levels, calculated as magnesium intake minus magnesium excreted in faeces. However, this outcome was probably due to lower faecal excretion of magnesium. Magnesium stabilizes your nervous system which in turn prepares your body and mind for a deeper sleep. It triggers the neurotransmitters to help calm your senses. Promotes Healthy Blood Pressure. A meta-analysis of 34 randomized control trials found that magnesium reduced blood pressure.[20] However, the effect size is clinically small (<2 mmHg). Therefore, it may be good for supporting overall health and healthy blood pressure, but you may also need other interventions to achieve healthy blood pressure levels. In a clinical trial involving 73,684 postmenopausal women, low magnesium intake was associated with lower bone density in the hip and whole body. Magnesium intake slightly higher than the Recommended Dietary Allowance was associated with lower arm and wrist fractures from falling.In one study, volleyball players who took 250 mg of magnesium per day experienced improvements in jumping and arm movements Less than one percent of the total body magnesium is found in your serum. Despite magnesium deficiency, your body strives to maintain a relatively stable level of serum magnesium. As a result, serum magnesium level is not the most reliable marker for assessing magnesium status in the body. Other indicators should be considered to accurately evaluate magnesium levels within the body.