Gene Machine: The Race to Decipher the Secrets of the Ribosome

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During development, totipotent cells translate only part of their DNA, resulting in cell specialisation. The one thing that I can confidently say after reading this book, is that Dr. Ramakrishnan does not mince words. It was a highly personal view of his involvement in the field of structural biology, complete with bitter comments and sardonic jokes against his competitors, praise and attributions towards his students and friends, his constant worries and fear of being a nobody or a has-been in the field, and most importantly, of what it means to follow a goal or an ambition. As a science student myself, reading about a Nobel prize winner starting off his book by talking about how he had no clue what he had to do after his graduate studies and essentially stumbling from one path to another, was perhaps the most uplifting thing I have read till now. Gene Machine has been designed to comfortably accommodate up to 10 guests in 5 suites. The supremely spacious full beam master suite benefits from a his and her bathroom. She is also capable of carrying up to 13 crew onboard to ensure a relaxed luxury yacht experience. Onboard Comfort & Entertainment What Malvolio said in Shakespeare’s Twelfth Night equally applies to Nobels: some are born great, some achieve greatness, and some have greatness thrust upon them."

A thoroughly sublime read. Dr. Venki's humility and honesty shines through in each chapter. His perseverance in his work despite failure and competition is a true testimony to the nature and spirit of science. Here are some of the quotes I highlighted while reading the book: Invented by engineer and entrepreneur Jonathan Rothberg, such desktop gene machines could transform medicine, agriculture, nanotechnology and the search for alternative fuels. Using DNA sequencing, Rothberg says, doctors in the not-too-distant future will finger genetic weak spots in tumors and treat cancer patients with customized drugs. (This is already happening at some cancer centers.) Kids born with rare diseases will get large portions of their genome decoded to pinpoint the cause, eliminating guesswork and misdiagnoses. Immersive and inspiring. A great read for a graduate student in life sciences and anyone who likes popular science. Induced pluripotent stem cells (iPS cells) can be produced from adult somatic cells using appropriate

Boasting a beautiful interior designed by Enzo Enea, the yacht can comfortably accommodate 12 guests and 12 crew members. But existing machines from Illumina and Life Technologies can take up to eight days to return any data--an eternity for cancer patients who need treatment right away. Moreover, the current technology forces cancer pathologists to wait that entire time, even if they just want to analyze a few genes. It's almost like the difference between waiting for a letter and a text message. The na_sr cookie is used to recognize the visitor upon re-entry. It allows to record details on user behaviour and facilitate the social sharing function provided by Addthis.com.What raised this book to four stars for me was the mention of a possible other reason the third codon in DNA is usually redundant is the flexibilty it gives in toggling molecule parts. PreviouslyI had just latched onto the redundancy being protective of mutations, given most mutations occur at the third codon. Venki Ramakrishnan's landmark book on the race to identifiying the Rhibozome structure and understanding the protein creation and activation/deactivation mechanism is a mixed one. The journey could not be explained without understanding the science (physics, chemistry and philosophy!) and hence it doesn't shy away from making the reader aware of the intention. In one of the defining part so the book the author says to the effect 'people assume nobel prize winners are geniuses. Only a few of them are. The rest are just dedicated scientists who have given it they all' and that is the human element of it. DNA technology in the diagnosis and treatment of human diseases. Alteration of the sequence of bases in DNA can alter the structure of proteins (A-level only) Like Ditlev, the other Scandinavian I’ve had in the lab, she was intelligent, organized, pleasant, and cheerful and just generally well rounded. It made me wonder if Scandinavians are doing something right in the way they bring up their children, or whether taking them from dark Scandinavia and placing them farther south, even if only as far south as Cambridge, made them particularly cheerful and free of any Bergman-like angst."

Alexander] Gann at Cold Spring Harbor Lab, New York, a very fine scientist and also a science writer who edited the annotated version of The Double Helix, said, “You really should be writing this.” He’s been encouraging me all along. The last time I met him, he said, “Look, years have gone by. If you publish one more Nature paper, not many are going to read it. But if you write this book, you’re going to reach thousands of people. Not just half a dozen people who are going to read your paper in depth.”

The use of restriction endonucleases and ligases to insert fragments of DNA into vectors. Transformation of host cells using these vectors. A contrite clarification partly mollified some but further infuriated others because I had said nationality was an accident of birth. Some Hindu nationalists had already been annoyed with me because they had learned from news reports that in the aftermath of the Gujarat riots in 2002, I had supported a scholarship to help poor Muslim girls, partly as a gesture from someone who was of Hindu ancestry and partly because the education of girls lifts society as a whole everywhere. Now they had further reason to think I was a traitor to their cause."

Sometimes, the simplest questions are the most difficult to answer. One such is that of how many Indians have won the Nobel Prize so far. The figure can be as high as twelve, if you count Ronald Ross, Rudyard Kipling, Dalai Lama, V S Naipaul and Mother Teresa. Some or of Indian origin, or been born in India or left India too early in their career. Venkatraman Ramakrishnan was a graduate of Physics from Baroda but immediately migrated to the US for further studies. He won the Nobel in Chemistry in 2009 for ribosome research along with two others. Ramakrishnan’s research strengthened our understanding of the fundamental processes of life and provided a clue to the evolution of modern species of life. This book is a combination of popular science and an autobiography with a seamless blending of the two. His life is devoted to research and learning. This book presents some valid advice to novices in scientific research. The author asks them not to be hesitant to ask questions, however basic it might be. He justifies it by claiming that no question is too stupid to ask if you want to know the answer. It is also a bare necessity for present-day researchers to belong to the top-line institutes and laboratories. Advanced science has now become a team effort transcending national frontiers and continental boundaries. The members of the theoretical and testing facilities should be known to each other, otherwise it would be difficult to obtain and manage precious time allocated for using sophisticated machines.An amazing, honest and humbling look into the race to discover the structure of the 30 subunit and 50 subunit structure of the ribosome. Venki's journey from grad school to the foremost of science, his struggles in the cut-throat, competitive world of academia, frustration with troublesome colleagues are presented quite well here. A fast-paced read! Gene expression is controlled by a number of features (A-level only) Most of a cell’s DNA is not translated (A-level only) Once isolated, the mRNA is then combined with a reverse transcriptase enzyme and nucleotides to create a single strand of complementary DNA ( cDNA) Each of the 7 lessons which are included in this bundle have been written to specifically cover the content as detailed in topic 8 of the AQA A-level Biology specification (The control of gene expression). The wide range of activities will maintain engagement whilst supporting the explanations of the biological knowledge to allow the students to build a deep understanding of this potentially difficult topic!