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CTCAE results demonstrated a decrease in the incidence of ≥ grade 2 peripheral neuropathy on the intervention side ( p< .

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Factors influencing the effectiveness of scalp cooling in the prevention of chemotherapy-induced alopecia. They should control for the potentially different impact cooling may have on CIPN in the setting of different chemotherapy drug regimens. An additional limitation is this review’s use of “colder” compared with “less cold” categories in interpreting findings. The difference in drug regimens used within the studies is of particular concern since the mechanism of nerve injury is theorized to differ between peripherally neurotoxic chemotherapies ( Shah et al. For the purpose of this review, studies were categorized as providing a relatively greater degree of cooling or a relatively lesser degree of cooling.Extensor digitorum brevis compound motor action potential amplitudes more preserved on intervention side below fibula head ( p = . Detailed descriptions and results of these studies are outlined above in the section titled “degree of cooling” in Table 1. The true level of tolerability of peripheral cooling has not been determined, and the range of tolerability reported in the studies reviewed here is in keeping with the range of tolerability reported in other studies that used cooling to prevent dermatologic toxicities.

The Impact of Peripheral Cooling on Chemotherapy-Induced

Patients received either three cycles of epirubicin and cyclophosphamide followed by three cycles of docetaxel or six cycles of docetaxel and cyclophosphamide. Advanced practitioners may advise patients that to date, more studies have examined the benefits of applying greater degrees of cooling using cooled socks and gloves than other methods that apply less cooling, and that perhaps as a result, there is more evidence to suggest that applying a relatively greater degree of cooling using the same method may provide more benefit compared with less cooling.

Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent, potentially long-lasting side effect of select chemotherapies. Occurrence of Patient Neurotoxicity Questionnaire grades D or E peripheral neuropathy reduced with intervention (hand: 2. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis.

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Additionally, the difference in the findings by Griffiths and colleagues (2018) compared with findings in the studies by Eckhoff and colleagues (2013), Hanai and colleagues (2018), and Sato and colleagues (2016) may be attributable to the different outcome measurement tools used in the Griffiths and colleagues study. Compound motor action potential amplitudes of motor nerves more preserved at 3 months post treatment. Patients may be counseled that there are limited data on using regional cooling to reduce the severity of CIPN. Results of studies in this review were also categorized by the method of cooling they employed, either using direct-cooling or compression.

To date, interventions to effectively prevent this toxicity have not been established, and interventions to treat CIPN have produced only modest results. Eckhoff and colleagues (2013) conducted a randomized, prospective, phase III trial of 1,725 Danish breast cancer patients to evaluate CIPN in patients receiving two docetaxel-based chemotherapy regimens. The compound motor action potential (cMAP) amplitudes of motor nerves were more preserved on the intervention side at 3 months post-treatment evaluation; however, these results also did not achieve statistical significance (extensor digitorum brevis cMAP amplitudes more preserved on intervention side below fibula head [ p = . The method of cooling refers to whether direct application of a cooling device or the use of compression was used in the study to achieve a decrease in temperature at the intervention site.