Modulen Ibd Latte Polvere 400g

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A new study has found that the Crohn’s Disease Exclusion Diet (CDED), a novel whole-food based dietary approach, combined with Modulen IBD, a Nestlé Health Science nutritional supplement for partial enteral nutrition (PEN), is effective for the management of Crohn’s disease. There is no cure for Crohn’s disease- a chronic condition that causes inflammation of the digestive system or gut. Most patients typically rely on anti-inflammatory drugs and surgical interventions to manage their symptoms, which can be expensive, for both the patient and health care providers. However, a randomized control trial, has shown that a nutrition-based approach, combining CDED and Modulen IBD is effective for the management and remission of Crohn’s disease. Nestlé Health Science, a leader in the science of nutrition, is a globally managed business unit of Nestlé. We are committed to redefining the management of health, offering an extensive portfolio of science-based consumer health, medical nutrition, pharmaceutical therapies, and vitamin and supplement brands. Our extensive research network provides the foundation for products that empower healthier lives through nutrition. Headquartered in Switzerland, we have more than 12,000 employees around the world, with products available in more than 140 countries. Modulen ® effectiveness to induce remission has been shown in many studies ( Table 1). These studies have several limitations, while they are mainly retrospective or with no randomized control, and the endpoints were clinical remission rather than mucosal healing. Among patients treated exclusively with Modulen ®, 65% of patients (19/27 children) have displayed a PCDAI ≤ 15 after 6–8 weeks [ 1] and 79% (23/29 children) have reached clinical remission with a PCDAI ≤ 10 after 8 weeks of CT32I Nestlé ® formula treatment [ 2]. A similar rate (80%) has been described by Buchanan et al. (105/114 children), who have combined both oral and nasogastric administration [ 3]. The mode of administration depends on patients’ clinical status [ 33], but does not affect the clinical remission rate. After eight weeks of exclusive Modulen ®, oral and nasogastric administration induces 75% and 85% of clinical remission respectively (PCDAI < 10), without any statistical difference between treatments ( Table 2) [ 4]. Considering the severe corticosteroid side effects, numerous studies have already illustrated that exclusive nutrition has an equal efficiency to corticosteroids in children contrary in adults [ 34]. To our knowledge, only two studies comparing corticosteroids to exclusive nutrition have been performed by adopting the current Modulen ® formula [ 5, 6]. In the first one [ 5], an exclusive 10-week diet induced clinical remission and the PCDAI reduction was similar to corticosteroid treatment. However, endoscopic and histological healing was achieved at 73% in the polymeric diet group (14/19 children), significantly higher compared to 40% in the corticosteroid group (6/15). In the second one [ 6], PCDAI significantly decreased after eight weeks of polymeric diet compared to corticosteroids, from the second week until the third. In a long-term follow-up on mesalamine maintenance, the remission rate was longer when the induction treatment was performed by the polymeric diet, as more than 80% of individuals were in remission one year after. Another study has compared corticosteroids, cyclosporine A and enteral nutrition (EN) with an elemental diet (Flexical, Mead Johnson) or a polymeric diet (Nestlé) ( Table 1) [ 35]. After 8 weeks of treatments, among the three patients treated with the polymeric diet, two of them had an improved histological inflammation. This outcome was similar to the elemental diet (5/6) and cyclosporine A (6/9), while it did not improve on prednisolone (1/10). However, the number of TNFα secreting cells only decreased on cyclosporine A.

Finally, in addition to gut integrity, Modulen ® elements will likely benefit other organs and physiological processes allowing a well-being stage. Naturally, physical ameliorations go along with mental ones, thus achieving an effective quality of life. Because ModuLife is physician-supervised, patients and their healthcare providers can easily collaborate to ensure that patients receive ongoing support and maintain habits that prolong the remission of their disease.

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for use in Crohn’s disease either as an alternative to steroid therapy during the active phase, as a supplement during the remission phase or adjunct to medical steroid therapy.

Modulen ® is different from other EN formulas mainly by its TGF-β2 amount ( Figure 1 right panel) [ 32]. This cytokine has intestinal benefits such as promoting IgA production, regulating tight junction proteins, and preventing Goblet cell depletion [ 41]. Furthermore, stimulating intestinal cells with TGF-β2 has down-regulated CXCL-8, IL-6, and TNFα ( Figure 1, right panel) [ 42]. This lessening concerns both macrophage cytokines [ 42] and transcriptional level modifications [ 42, 43]. Moreover, depleting TGF-β signalling emphasizes weight loss and inflammation in a mouse model of colitis [ 43]. Other studies have shown the ability of TGF-β2 to prevent necrotizing enterocolitis [ 44] and mucositis [ 45]. Knowing that TGF-β is also involved during restitution of mucosal healing [ 41], remission outcomes obtained with Modulen ® could be principally explained by this cytokine ( Figure 1, right panel). However, other components may play a potential role and should not be excluded. This is the case of protein and fatty acid contents that deserve interest. Gut Friendly Recipes offers dietitian-approved recipes for people with digestive issues, Inflammatory Bowel Disease (IBD) patients, and for general nutritious eating Even though studies are contradicting each other about Modulen ® efficiency on disease location [ 3, 4, 10], numerous clinicians noticed that at least one ileal damage is requested. The pathophysiological differences may explain this outcome. For instance, NOD2 mutations are associated with CD with at least one lesion located in the small intestine. In view of its numerous intestinal functions, this receptor can play a significant role in EN mechanisms after microbiota recognition. This suggests that the possible modification of the intestinal microbiota by Modulen ® could be primordial to induce remission. Additional studies on intestinal consequent microbiota are encouraged, both in terms of taxonomy and time. Albeit the outcome could suggest enhancing the dietary therapy with prebiotics or probiotics, one should note that the contrary could appear if the ensuing microbiota variations are highly specific.The new Gut Friendly Recipes a free, online, recipe finder with more than 500 easy recipes for gut-friendly and nutritious meals, helps to answer that question. The easy-to-navigate recipe finder was launched on January 31, 2023 by the Crohn’s & Colitis Foundation and Nestlé Health Science.