Myo-Inositol & D-Chiro Inositol | Hormone Balance for Women | Ideal 40:1 Ratio | Myo Inositol 2000mg, D Chiro 50mg | Vitamin B8 to Regulate Menstrual Cycle & Support Ovarian Health | SM Nutrition

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Oliva, M. M.; etal. (2018). "Effects of myo-inositol plus alpha-lactalbumin in myo-inositol-resistant PCOS women". Journal of Ovarian Research. 11 (1): 38. doi: 10.1186/s13048-018-0411-2. PMC 5944130. PMID 29747700.

M.G., et al., Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med, 2003. 254(5): p. 455-63. Nordio M, Basciani S, Camajani E. The 40:1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios. Eur Rev Med Pharmacol Sci. 2019;23:5512–21. Colazingari, S.; etal. (2013). "The combined therapy myo-inositol plus D- chiro-inositol, rather than D- chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial". Archives of Gynecology and Obstetrics. 288 (6): 1405–11. doi: 10.1007/s00404-013-2855-3. PMID 23708322. S2CID 45611717.

40:1 and the metabolic benefits

Stentz R, Osborne S, Horn N, Li AW, Hautefort I, Bongaerts R, Rouyer M, Bailey P, Shears SB, Hemmings AM, Brearley CA, Carding SR (27 February 2014). "A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut". Cell Reports. 6 (4): 646–656. doi: 10.1016/j.celrep.2014.01.021. PMC 3969271. PMID 24529702. Anna, R., et al., Myo-inositol may prevent gestational diabetes in PCOS women. Gynecol Endocrinol, 2012. 28(6): p. 440-2. R.F., et al., The feasibility of a diet which enhances inositol availability. Progress in Nutrition, 2021. 23(2): p. e2021078. But the best inositol supplement for PCOS contains both myo-inositol and D-chiro-inositol. Studies show that a mixture of 40 parts myo-inositol to 1-part D-chiro-inositol is more effective than other formulations [ 49]. 40:1 is the physiological ratio that these two inositol isomers are found in the body.

Kalra B, Kalra S, Sharma JB. The inositols and polycystic ovary syndrome. Indian J Endocrinol Metab. 2016;20(5):720–724. doi:10.4103/2230-8210.189231 It’s recommended that women with PCOS take a combined amount of MYO (2 to 4 grams) and DCI (50 to 100 mg) daily in the ideal physiologic ratio of 40:1. Ovasitol is what I recommend because it has passed the rigorous 3rd party testing to have the NSF certification. It’s also a tasteless and convenient powder (no more pills to swallow!) In my experience, both personally and as a health coach, no supplement can compete with a PCOS diet for efficacy.Isabella, R.; Raffone, E. (2012). "Does ovary need D- chiro-inositol?". Journal of Ovarian Research. 5 (1): 14. doi: 10.1186/1757-2215-5-14. PMC 3447676. PMID 22587479. M. and D.T. Archer, Metformin and Micronutrient Status in Type 2 Diabetes: Does Polypharmacy Involving Acid-Suppressing Medications Affect Vitamin B12 Levels? Diabetes Metab Syndr Obes, 2020. 13: p. 2093-2108. When plants are exposed to increasing concentrations of road salt, the plant cells become dysfunctional and undergo apoptosis, leading to inhibited growth. Inositol pretreatment could reverse these effects. [25] Research and clinical applications [ edit ] Psychiatry [ edit ] Depression [ edit ]

Le Donne M, Metro D, Alibrandi A, Papa M, Benvenga S. Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome. Eur Rev Med Pharmacol Sci. 2019 Mar;23(5):2293-2301. doi:10.26355/eurrev_201903_17278.If you’re not buying Ovasitol, then it’s best to buy only pure myo-inositol. Jarrow Formulas is a well-priced and reliable brand. Pure Encapsulations also make a top-quality myo-inositol product. D. and R. Tal, Inositol Treatment and ART Outcomes in Women with PCOS. Int J Endocrinol, 2016. 2016: p. 1979654. Turan GA, Eskicioglu F, Sivrikoz N, Cengiz H, Adakan S, Gur EB, et al. Myo-inositol is a promising treatment for the prevention of ovarian hyperstimulation syndrome (OHSS): an animal study. Arch Gynecol Obstet. 2015;292:1163–71.