Dried Cep/Porcini Powder, 100g

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Fly agaric ( amanita muscaria), the miller ( Clitopilus prunulus) and peppery boletes ( Chalciporus piperatus) are often clues to good hunting -grounds, especially under spruce trees. I find the relationship between ceps, spruce trees, the miller and the peppery bolete to be so reliable that I believe (though i’ve seen no scientific research to prove this) that the relationship is more than just shared habitat, but a complex interdependency. It has been known for some years that peppery boletes are parasitic on fly agaric mycelia, but I suspect there is more at play here. Who knows what complex battles, alliances and trades are going on beneath our feet!? Paudel, K.R.; Karki, R.; Kim, D.-W. Cepharanthine Inhibits in Vitro VSMC Proliferation and Migration and Vascular Inflammatory Responses Mediated by RAW264.7. Toxicol. Vitr. 2016, 34, 16–25. [ Google Scholar] [ CrossRef] [ PubMed]

Kao, M.C.; Yang, C.H.; Chou, W.C.; Sheu, J.R.; Huang, C.J. Cepharanthine Mitigates Lung Injury in Lower Limb Ischemia–Reperfusion. J. Surg. Res. 2015, 199, 647–656. [ Google Scholar] [ CrossRef] Cepharanthine (CEP) is a bis-benzylisoquinoline alkaloid isolated from plants of Stephania genus in 1934 ( 24). In 1937, the application of CEP enormously reduced the average mortality rate among patients with severe pulmonary tuberculosis from 41 to 22% at the Yokohama Sanatorium in Japan ( 25). But it has since been superseded by more effective drugs ( 26). Nonetheless, the initial successful clinical application of CEP in the treatment of tuberculosis has encouraged its utilization in other pathological indications, such as anti-inflammation, analgesia, anti-virus, and anti-tumor activity ( 27– 30). In the last few years, CEP has attracted increasing attention in research due to its distinct 1-benzylisoquinoline moiety similarities with natural polypeptides, physiological properties, and long-established remarkable safety profile ( 31). In December 2019, the emergence of the 2019 novel coronavirus disease (labeled COVID-19), caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has posed an unprecedented challenge to global public health. In a large drug screen of 2406 clinically approved drugs, CEP was recently identified as the most effective drug against SARS-CoV-2-related pangolin coronavirus. CEP has become a drug of interest for treating COVID-19 ( 31– 33). It is suggested that CEP is not a “one pill fits all” medication but certainly an under-explored drug which should be reconsidered ( 34). Increasing studies have indicated that CEP has a variety of pharmacological activities, implying that will play a crucial role in clinical trials. Nevertheless, CEP has the defect of low water solubility and low direct oral bioavailability which limit its pharmacological validity ( 35). The absolute bioavailability of CEP by oral route was only 5.65 ± 0.35% in rats ( 36). Therefore, it is urgent to explore effective means to boost oral bioavailability to meet the clinical needs of CEP. Bailly, C. Cepharanthine: An Update of Its Mode of Action, Pharmacological Properties and Medical Applications. Phytomedicine 2019, 62, 152956. [ Google Scholar] [ CrossRef] Cep mushrooms are celebrated for their intense umami flavour, often referred to as the “king of mushrooms.” Our powder captures this deep, earthy essence, adding complexity and depth to your dishes. Enhance soups, sauces, risottos, pasta dishes, and more with its distinct flavour profile. It’s a fantastic addition to both vegetarian and meat-based recipes.Hijikata, A.; Shionyu-Mitsuyama, C.; Nakae, S.; Shionyu, M.; Ota, M.; Kanaya, S.; Hirokawa, T.; Nakajima, S.; Watashi, K.; Shirai, T. Evaluating Cepharanthine Analogues as Natural Drugs against SARS-CoV-2. FEBS Open Bio 2022, 12, 285–294. [ Google Scholar] [ CrossRef] A potato rösti isn’t really, but let’s not get too hung up on nomenclature: it’s a plank of multilayered sliced potatoes, deep fried to an encouraging golden. There’s a cloud-like smoked-potato purée draped across the top, dusted with cep powder and, next to it, a spoonful of a boisterously acidulated mushroom ketchup. Oh boy. Ecology –Ceps are Mycorrhizal fungi, working with their tree partners by helping in their uptake of water, phosphorus, nitrogen and zinc in return for energy from photosynthesis in the form of sugars. Carbon sequestration by fungi is often an overlooked area of climate science. Ceps, and boletus species in general, can be important food and habitat to insects, slugs, rodents and I’ve even heard of deer nibbling on them. This fascinating paper shows that individual mushroom species can have specific relationships with individual insect species. In the case of ceps, (mostly) flies of the pegomya genus, and (some) fungal gnats of Sciaridae family use them as food home & nursery for their larvae. It has been postulated that insects could play a role in the reproductive strategies of some fungi (beyond the obvious stinkhorns) and who knows what other useful interactions they have with complex fungal lifecycles? The evolution of veils/rings ( annulus), webs ( cortina) and slime on the underside of some mushroom species is a direct defence to deter insects before spores have matured. Some slow growing fungi such as chanterelles deter insects chemically ( read the science of this here). That ceps have evolved no such strategy suggests to me that they they are happy partners with insects as well as trees! It seems likely that their very aromatic deliciousness has evolved to attract insects… And maybe humans too? Ceps can also play host to other fungi, notably the bolete eater fungus Hypomyces chrysospermus, and appear to have complex relationships with Fly agaric ( amanita mascaria), the miller ( Clitopilus prunulus) and peppery boletes ( Chalciporus piperatus) – more on which below.

Yasuda, K.; Moro, M.; Akasu, M.; Ohnishi, A. Pharmacokinetics of Cepharanthin in phase I clinical trials (single and continuous intravenous administration). Clin. Pharmacol. 1989, 20, 741–749. [ Google Scholar] [ CrossRef] For the salt-baked celeriac, wrap celeriac in salt crust and cook for 40-60 minutes, depending on the size of the celeriac, at 180°C. Use a temperature probe to ensure the centre of the celeriac reaches 65°C. Rest in the crust for 30 minutes, then open and chill. Slice as thinly as possible. Start with the filling. Combine the cream and parmesan in a bain-marie (a type of heated water bath; you can fashion your own by placing a bowl in a large casserole dish filled with warm water. Place the ingredients in the bowl), stirring gently for 10 mins. Leave to rest in fridge for minimum of 12 hours, which prevents splitting. For future date deliveries select the Express delivery option that best suits your needs, End of Day. Pre-1pm or Pre-10.30am. We deliver Tuesday through until Saturday, we do not deliver on Sunday.

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Mushrooms are harder to identify than plants: there is less to go. And making a similar mistake of the sort that I made with fruit on those occasions with the wrong deadly mushroom, could lead to at least significant morbidity. Malaviya, R.; Laskin, J.D.; Laskin, D.L. Anti-TNFα Therapy in Inflammatory Lung Diseases. Pharmacol. Ther. 2017, 180, 90–98. [ Google Scholar] [ CrossRef] [ PubMed] Season the venison and place a large heavy-based pan over a medium heat. Add the meat and brown it all over. Once coloured, add 100g/3½ oz of the cep butter and use it to baste the meat until cooked to your liking. Allow to rest. The SEM images of the cepharanthine dry powder inhaler according to different treatment methods. ( A) Cepharanthine (scale bar = 60 μm); ( B) Cepharanthine API light-proof grinding (scale bar = 6 μm); ( C) Cepharanthine acetate solution alone freeze-dried (scale bar = 20 μm); ( D) Cepharanthine: Mannitol = 1:1 freeze-dried (scale bar = 6 μm); ( E) Cepharanthine: Mannitol = 1:2 freeze-dried (scale bar = 20 μm); ( F) Cepharanthine: Mannitol = 1:3 freeze-dried (scale bar = 20 μm); ( G) Cepharanthine: Mannitol = 1:5 freeze-dried (scale bar = 20 μm); ( H) Cepharanthine: Lactose = 1:5 freeze-dried (scale bar = 60 μm). Nader, N.D.; Knight, P.R.; Bobela, I.; Davidson, B.A.; Johnson, K.J.; Morin, F. High-Dose Nitric Oxide Inhalation Increases Lung Injury after Gastric Aspiration. Anesthesiology 1999, 91, 741–749. [ Google Scholar] [ CrossRef] [ PubMed]

Fan, H.-H.; Wang, L.-Q.; Liu, W.-L.; An, X.-P.; Liu, Z.-D.; He, X.-Q.; Song, L.-H.; Tong, Y.-G. Repurposing of Clinically Approved Drugs for Treatment of Coronavirus Disease 2019 in a 2019-Novel Coronavirus-Related Coronavirus Model. Chin. Med. J. 2020, 133, 1051–1056. [ Google Scholar] [ CrossRef] Guide for the implementation of the principle of prohibition of financial gain with respect to the human body and its parts from living or deceased donors (2018) Newman, S.P. Fine Particle Fraction: The Good and the Bad. J. Aerosol Med. Pulm. Drug Deliv. 2022, 35, 2–10. [ Google Scholar] [ CrossRef] Bodier-Montagutelli, E.; Mayor, A.; Vecellio, L.; Respaud, R.; Heuzé-Vourc’h, N. Designing Inhaled Protein Therapeutics for Topical Lung Delivery: What Are the next Steps? Expert Opin. Drug Deliv. 2018, 15, 729–736. [ Google Scholar] [ CrossRef]Delicately remove the crispy pastry from around the metal cylinders and reserve in a cool, dry space before ready to plate. Wheeler, A.P.; Bernard, G.R. Acute Lung Injury and the Acute Respiratory Distress Syndrome: A Clinical Review. Lancet 2007, 369, 1553–1564. [ Google Scholar] [ CrossRef] Fujishima, S. Pathophysiology and Biomarkers of Acute Respiratory Distress Syndrome. J. Intensive Care 2014, 2, 32. [ Google Scholar] [ CrossRef] Grill or barbecue the lamb for 10/15 minutes over a medium heat. The flame should not be too high so the marinade doesn’t burn. Once the meat is pink/medium, remove from the heat, drizzle some melted butter, a little lemon juice and some chopped fresh coriander and allow it to rest for 10 minutes, before carving into slices ready to serve.