Cranberry Capsules 35,000mg High Strength - with Probiotics/Bio Cultures and Vitamin C - 150 Capsules - Advanced Cranberry Extract Supplement - Made in UK by VitaBright

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The reviewers considered lag time as a potentially compromising variable in the results. In the Stapleton study, subjects were treated for acute UTI at visit 1 with standard therapy, given probiotics seven to 10 days after visit 1, and then reevaluated at 10 weeks [ 21]. It is unclear which antibiotic the authors deemed “standard therapy.” It was also unclear how long the subjects were treated for. If the antibiotic regimen was long enough to affect probiotic microbe viability, this may have prevented adequate colonization of the protective microbes in the urogenital tract. This is another variable in methodology that requires standardization across studies wishing to assess the efficacy of probiotics in treatment/prophylaxis of UTIs. Our impression is that the follow-up methodology of the Koradia study for follow-up was ideal as subjects were reevaluated on days 45, 90, 135 and end-of-study [ 22]. This time frame allows for antibiotics to effectively clear uropathogens while also allowing for probiotic colonization to take place, insofar as oral supplements are able to do so. Avorn J, Monane M, Gurwitz J, Glynn R I, Choodnovskiy I, and Lipsitz L A. Reduction of bacteriuria and pyuria using cranberry juice. JAMA 1994;272(8):588-590. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Swartz, J. H. and Medrek, T. F. Antifungal properties of cranberry juice. Appl.Microbiol. 1968;16(10):1524-1527. View abstract. Efros, M., Bromberg, W., Cossu, L., Nakeleski, E., and Katz, A. E. Novel concentrated cranberry liquid blend, UTI-STAT with Proantinox, might help prevent recurrent urinary tract infections in women. Urology 2010;76(4):841-845. View abstract.

ProVen Probiotics for Women - with Cranberry and Vitamin B6

Avoid the Greenwashing Trap: How Food Companies Can Build Trust and Transparency in Regenerative Agriculture The added advantage is that good probiotics are safe for human use and therefore carry negligible risk.​ Schmidt DR, Sobota AE. An examination of the anti-adherence activity of cranberry juice on urinary and nonurinary bacterial isolates. Microbios 1988;55:173-81. View abstract. Healthy bacteria are required to support both the digestive tract and the urogenital tract in women. For example, most urinary tract infections (UTIs), often referred to as cystitis, are caused by a species of bacteria called Escherichia coli ( E. coli), which generally live happily alongside the good bacteria in the gut and urogenital tract, but can sometimes grow and cause infection. Allison, D. G., Cronin, M. A., Hawker, J., and Freeman, S. Influence of cranberry juice on attachment of Escherichia coli to glass. J Basic Microbiol. 2000;40(1):3-6. View abstract.The use of probiotics as a strategy in the management of patients with rUTIs is a relatively new field of study. It is largely based on research that has disproven the long-held notion that the human bladder is a sterile environment as more research points to the existence of a genitourinary microbiome [ 13, 14]. The literature has demonstrated that, similar to the gastrointestinal tract, the urogenital tract contains a variety of microbes that play a role in homeostasis of the urinary microenvironment by altering local metabolite concentrations and pH [ 14]. With the advent of next-generation sequencing and advanced culturing techniques, researchers have been able to identify the bacteria that make up the resident flora in the bladder [ 15]. Although a consensus on the exact makeup of the bladder microbiota has yet to be reached, research on urinary symbiotic and pathogenic microorganisms has found remarkable differences between healthy populations and those suffering from various diseases [ 15]. Sylvan, L. and Justice, N. P. Possible interaction between warfarin and cranberry juice. Am Fam.Physician 9-15-2005;72(6):1000. View abstract. The urogenital tract comprises both the urinary tract and the vagina and both contain a microbiome (bacteria) in the same way as the gastrointestinal tract. Lactobacillus is the primary bacteria of the vagina of healthy women and the growth of too many other strains can lead to an imbalance in the natural bacteria of the vagina. Another variable that may partially explain the result of our review is the inclusion of only adult premenopausal women (i.e., 18 to 50). The literature on rUTIs in premenopausal women suggests that the risk factors in this age group differ from those in the postmenopausal age group [ 41]. Premenopausal women are more likely to have recent antibiotic use, an individual history of UTIs, use of an intrauterine device, use of spermicidal condoms, and recent sexual intercourse [ 6]. These risk factors have an indeterminate level of impact on the ratio of uropathogens to protective microorganisms in this population and are not entirely controlled for in most published studies. Perhaps more importantly is the composition of the female bladder microbiota pre- and post-menopause. Antonio et al. have demonstrated that postmenopausal women have 25% to 30% of the LB in the vagina compared to premenopausal women [ 16]. Other researchers have also demonstrated that estrogen therapy may increase this percentage of vaginal LB to 60-100% [ 42]. Because premenopausal women do not appear to be as deficient in beneficial LB, our impression is that premenopausal women may not experience as much benefit from supplemental probiotics containing LB. The findings of Uehara et al. support this notion as they have demonstrated a significant reduction in the number of UTI recurrences in postmenopausal women treated with intravaginal probiotics [ 36]. Along with implementing standardized bacterial strains, future researchers may aim to administer probiotics via routes that have proven to effectively colonize the vagina, bladder, and urogenital tract.

Pro-Ven Women’s Lactobacillus With Cranberry 30 Capsules

Premenopausal women with current, symptomatic, uncomplicated UTI. Median age (years): treatment group (21); control group (21). Avorn J, Manone M, Gurwitz JH, et al. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA 1994;271:751-4. View abstract.The patients received either a placebo or the Bio-Kult Pro-Cyan​​ supplement containing Lactobacillus acidophilus​ and Lactobacillus plantarum​ plus cranberry proanthocyanidins (PACs) and vitamin A (1 capsule twice per day) over the duration of six months. Contains Lab4 friendly bacteria together with a special strain of bacteria, Lactobacillus gasseri, which is a normal part of the vaginal flora Jepson RG, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2008;(1):CD001321. View abstract. Essadi F, Elmehashi MO. Efficacy of cranberry juice for the prevention of urinary tract infections in pregnancy [abstract]. J Matern Fetal Neonatal Med 2010;23:378. Neto, C. C., Amoroso, J. W., and Liberty, A. M. Anticancer activities of cranberry phytochemicals: an update. Mol.Nutr Food Res 2008;52 Suppl 1:S18-S27. View abstract.