Joined in 2023 
82 
63 About this deal
Lacaille B, Julien P, Deshaies Y, et al. Responses of plasma lipoproteins and sex hormones to the consumption of lean fish incorporated in a prudent-type diet in normolipidemic men. J Am Coll Nutr 2000;19:745-53. View abstract. Sensitivity analyses were conducted including only studies with low risk of bias (high quality), i.e., only those judged as high and fair quality and only those with ITT estimates. Additionally, a leave-one-out sensitivity analysis was performed by removing one study at a time to confirm that the results were not influenced by any single study. Potential publication bias was explored using funnel plot asymmetry [ 38]. p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 13.0px Arial; color: #323333; -webkit-text-stroke: #323333} span.s1 {font-kerning: none} --> Mori TA, Burke V, Puddey IB, et al. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr 2000;71:1085-94. View abstract.
The fastest and most efficient way to determine your omega-3 requirements is by taking a blood test to determine your omega-3 index and working with your doctor to determine a dosing regimen that best suits your needs. The omega-3 index is a measure of the relative amount of EPA and DHA in red blood cells, expressed as the percentage of the total amount of fatty acids present. If an individual has an omega-3 index of 3.6%, this means that 3.6% of all fatty acids present in their red cell membranes is EPA+DHA. Aslan, A. and Triadafilopoulos, G. Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. Am J Gastroenterol 1992;87(4):432-437. View abstract. The essential fatty acids in UnoCardio X2 pure fish oil are available in the preferred r-triglyceride form, the molecular form which makes up virtually all fats and oils in nature (the cheaper ethyl ester form is only created through chemical synthesis). As such, UnoCardio X2 is more bioavailable (absorbable by the body) than most other fish oil supplements you'll find on the UK market. So what does fish oil do exactly, and why should we consider incorporating a high-strength omega-3 into our day-to-day regimen?Berbert, A. A., Kondo, C. R., Almendra, C. L., Matsuo, T., and Dichi, I. Supplementation of fish oil and olive oil in patients with rheumatoid arthritis. Nutrition 2005;21(2):131-136. View abstract. Pharmacotherapeutic group: omega-3-triglycerides, including other esters and acids; ATC code: C10AX06. MOST CONCENTRATED FISH OILS are made as ethyl esters, containing 60% to 80% omega-3. Although the omega concentration is somewhat higher, these fatty acids are not in a very bioavailable form and still contain up to 40% unnecessary or even unhealthy other fats. Borgeson, C. E., Pardini, L., Pardini, R. S., and Reitz, R. C. Effects of dietary fish oil on human mammary carcinoma and on lipid- metabolizing enzymes. Lipids 1989;24(4):290-295. View abstract.
Bartram, H. P., Gostner, A., Scheppach, W., Reddy, B. S., Rao, C. V., Dusel, G., Richter, F., Richter, A., and Kasper, H. Effects of fish oil on rectal cell proliferation, mucosal fatty acids, and prostaglandin E2 release in healthy subjects. Gastroenterology 1993;105(5):1317-1322. View abstract. Kuhnt K, Weiß S, Kiehntopf M, Jahreis G. Consumption of echium oil increases EPA and DPA in blood fractions more efficiently compared to linseed oil in humans. Lipids Health Dis. 2016 Feb 18;15:32. View abstract. Fernández-Portero C, et al. (2023). Coenzyme Q10 levels associated with cognitive functioning and executive function in older adults. Erkkila AT, Lehto S, Pyorala K, Uusitupa MI. n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. Am J Clin Nutr 2003;78:65-71.. View abstract.Almallah, Y. Z., Richardson, S., O'Hanrahan, T., Mowat, N. A., Brunt, P. W., Sinclair, T. S., Ewen, S., Heys, S. D., and Eremin, O. Distal procto-colitis, natural cytotoxicity, and essential fatty acids. Am.J.Gastroenterol. 1998;93(5):804-809. View abstract.
Taking 250 mg of DHA a day contributes to brain and eye health, whilst a daily intake of 250 mg of EPA and DHA supports cardio health. Arteaga, A., Villanueva, C. L., Skorin, C., Guasch, V., Solis, de Ovando, Velasco, N., Acosta, A. M., and Leighton, F. [Dyslipidemic patients with coronary cardiopathy. Effect of different doses of OMEGA-3 fatty acids on serum lipids and lipoproteins]. Rev Med Chil. 1993;121(6):618-625. View abstract.
Notably, these intake recommendations are substantially higher than other health organizations, who generally recommend healthy adults consume a minimum of 500 mg of EPA+DHA daily. 5 It is important to recognize that these more modest intake recommendations are suggested minimums, rather than recommendations for optimal cellular health and functioning. Moreover, these modest intake recommendations are informed by research using smaller doses, when we now have sufficient evidence that omega-3 doses as large as 5000 mg are safe for daily consumption and more effective for raising the omega-3 index towards cardioprotective levels than smaller doses. 6,19,22,27 Whereas most concentrated fish oils on the market are in the form of ethyl ester, a synthetic fat, UnoCardio® formulas are produced in true r-triglyceride (rTG) form. Research has shown that the bioavailability, body's absorption rate of fatty acids, of the r-triglyceride form is of great significance – up to 70% greater than ethyl esters. It’s worth noting that while CoQ10 supplements have been linked to benefits for heart health, exercise performance, and more, most studies suggest a dose of at least 100 mg per day. Because this supplement only provides 30 mg, people interested in the benefits of CoQ10 may need to take an additional supplement.
Certifications: We prioritized products with additional certifications from independent organizations to help ensure quality, transparency, and safety beyond third-party testing. However, we also included many products that use other methods to verify quality. Quality: In addition to the quality of ingredients, we looked at the company’s testing and manufacturing processes. The products selected are made by companies that provide objective measures of trust, such as having their supplements validated by third-party labs. Some people might also prefer opting for cod liver oil instead, as it provides other important nutrients in addition to omega-3s, including vitamins A and D. Which fish oil is best for inflammation? Alexopoulos, E., Stangou, M., Pantzaki, A., Kirmizis, D., and Memmos, D. Treatment of severe IgA nephropathy with omega-3 fatty acids: the effect of a "very low dose" regimen. Ren Fail. 2004;26(4):453-459. View abstract. Previous research found the average non-supplementing American had an omega-3 index value between 4 to 5 %, which is well below cardioprotective levels. Given that experts typically recommend targeting an omega-3 index between 8% and 12%, these results suggest that the average American would benefit from increasing their omega-3 index through supplementation. 19,23,24Reported relevant outcomes and the results of the included trials are shown in Table S2 (Supplementary Materials). In 14 RCTs, the BDI was applied as the instrument to evaluate the outcome, six studies applied the HDRS, five studies used the Geriatric Depression Scale (GDS) [ 53], four studies used the MADRS, and one study used the Children’s Depression Inventory (CDI) [ 54]. Ten RCTs used more than one assessment to determine depressive symptoms. Wang J, et al. (2023). Does omega-3 fatty acid supplementation have favorable effects on the lipid profile in postmenopausal women? A systematic review and dose-response meta-analysis of randomized controlled trials. Sublette, M. E., Ellis, S. P., Geant, A. L., and Mann, J. J. Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. J.Clin.Psychiatry 2011;72(12):1577-1584. View abstract.
Great Deal 
New Comment