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Swayne, D.F., Cook, D. & Buja, A. XGobi: interactive dynamic data visualization in the X Window System. J. Comput. Graph. Stat. 7, 113–130 (1998). VBel: Methodology, Writing—original draft, Writing—review and editing. VBet: Writing—review and editing. AM: Writing—review and editing. DD: Writing—review and editing, Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing—original draft. Funding On the evening of Thursday, March 4, De Niro and actor Harry Dean Stanton stopped by Belushi’s bungalow to urge him to go with them to dinner at Dan Tana’s and then to On the Rox, an exclusive Sunset Strip club. They found the room in a trashed state with Belushi and Smith amidst empty wine bottles, dirty laundry and pizza boxes. Hill, D.N., Mehta, S.B. & Kleinfeld, D. Quality metrics to accompany spike sorting of extracellular signals. J. Neurosci. 31, 8699–8705 (2011).

Gonzalez-Correa, J. M., Bayle Sempere, J. T., Sanchez-Jerez, P. & Valle, C. Posidonia oceanica meadows are not declining globally. Analysis of population dynamics in marine protected areas of the Mediterranean Sea. Mar. Ecol-Prog. Ser. 336, 111–119 (2007). Logothetis, N.K., Kayser, C. & Oeltermann, A. In vivo measurement of cortical impedance spectrum in monkeys: implications for signal propagation. Neuron 55, 809–823 (2007). Bouveyron, C. & Brunet-Saumard, C. Model-based clustering of high-dimensional data: a review. Comput. Stat. Data Anal. 71, 52–78 (2014). Agreeing to return after On the Rox closed, De Niro and Stanton left. Williams had met the actors at the nightclub and all planned on stopping by Belushi’s bungalow after Williams performed an unscheduled set at The Comedy Store. Williams arrived alone to find Belushi and Smith both in an inebriated state. According to The Castle on Sunset, Williams, like De Niro before him, found the scene unsettling and left after talking with Belushi – who had been complaining of feeling ill that evening – and doing a small amount of cocaine. De Niro, too, stopped by for a brief interaction before returning to his own suite at the Chateau Marmont sometime after 3 a.m. Belushi and Smith reportedly continued injecting cocaine mixed with heroin. Department of Earth Sciences, University of Cambridge, Downing Street, Cambridge, Cambridgeshire, CB2 3EQ, United KingdomPergent-Martini, C. et al. Mapping of coastlines of the Republic of Cyprus, Progress report. 38 pp. (GIS Posidonie, 2013).

Ben Alaya, H. Repartition et condition d’installation de Posidonia oceanica Delile et Cymodocea nodosa Ascherson dans le Golfe de Tunis. Bull. Instit. Nation. Peche de Salammbo 2, 331–416 (1972). Quirk, M.C. & Wilson, M.A. Interaction between spike waveform classification and temporal sequence detection. J. Neurosci. Methods 94, 41–52 (1999). Swindale, N.V. & Spacek, M.A. Spike detection methods for polytrodes and high density microelectrode arrays. J. Comput. Neurosci. 38, 249–261 (2015). Gobert, S. et al. Biology of Posidonia in Seagrasses: biology, ecology and conservation (eds Larkum, W. D., Orth, R. J. & Duarte, C. M. ) 387–408 (Springer, 2006). Stability: Normalized Root Mean Square ( nRMS) of the acceleration measured at pelvis, trunk, and head levels. The values were obtained for the AP, ML, and CC signal components as well as the magnitude value. High nRMS values have been associated with higher levels of acceleration, and hence, decreased stability [ 42];Marba, N. et al. Effectiveness of protection of seagrass ( Posidonia oceanica) populations in Cabrera National Park (Spain). Environ. Conserv. 29, 509–518 (2002). Luke Miels, Chief Commercial Officer, GSK said: “Patients suffering from severe forms of refractory chronic cough can experience over 900 coughs daily, resulting in quality-of-life issues. Camlipixant, a novel, highly selective P2X3 antagonist, has the potential to be a best-in-class treatment with significant sales potential. This proposed acquisition complements our portfolio of specialty medicines and builds on our expertise in respiratory therapies.” Einevoll, G.T., Franke, F., Hagen, E., Pouzat, C. & Harris, K.D. Towards reliable spike-train recordings from thousands of neurons with multielectrodes. Curr. Opin. Neurobiol. 22, 11–17 (2012). In 2015, Rolling Stone voted Belushi the greatest of all the SNL players, beating Eddie Murphy, Bill Murray and Tina Fey.

Jorda, G., Marba, N. & Durate, C. M. Mediterranean seagrass vulnerable to regional climate warming. Nat. Clim. Change 2, 821–824 (2012). Calabrese, A. & Paninski, L. Kalman filter mixture model for spike sorting of non-stationary data. J. Neurosci. Methods 196, 159–169 (2011). Molinier, R. & Picard, J. Recherches sur les herbiers de phanérogames marines du littoral méditerranéen français. Ann. I. Oceanogr. Paris 17, 157–234 (1952). From an applied biomechanics perspective, this work promotes the adoption of integrated instrumented approaches to motor performance assessment. The abundance of main effects for session, in both instrumented locomotion tasks, highlights how the IMU-based biomarkers could support the evaluation of the efficacy of the rehabilitative treatment, whether it is conventional or vestibular. The added value of our instrumented protocol is in the fact that we can go far beyond a global collective score (as happens in the clinical tests), giving the clinician the opportunity to objectively examine subtle improvements in gait quality from different domain perspectives (such as gait stability and smoothness, for instance). Belushi spent the majority of his final week in and around the Sunset Strip, hopscotching from one party scene to the next, be it the Roxy nightclub, Rainbow Bar and Grill and the restaurant Dan Tana’s on Santa Monica Boulevard, to name a few. His Chateau Marmont bungalow became a stop on the circuit after the clubs closed at 2 am, including visits from friends Robin Williams and Robert De Niro.GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Find out more at gsk.com/company. Cautionary statement regarding forward-looking statements relating to BELLUS Health Quiroga, R.Q., Nadasdy, Z. & Ben-Shaul, Y. Unsupervised spike detection and sorting with wavelets and superparamagnetic clustering. Neural Comput. 16, 1661–1687 (2004). Both groups showed a significant improvement in BBS, DGI, CB&M, and DHI scores in the within-subjects comparison over time. Specifically, the results of the Wilcoxon signed-ranks test highlight a significant improvement in BBS and DHI in both groups at T1, T2, and T3. The VRg showed a significant improvement in all three assessment times in the CB&M as well, while the CRg showed an improvement only 8 weeks after the end of the training (T3). Furthermore, only the VRg showed a significant improvement in the ABC and CIQ scores over the assessment sessions. Additionally, a significant between-group difference was found in the ABC and CIQ score. Hazan, L., Zugaro, M. & Buzsáki, G. Klusters, NeuroScope, NDManager: a free software suite for neurophysiological data processing and visualization. J. Neurosci. Methods 155, 207–216 (2006). Seagrass presence depends on a number of factors such as physical variables (e.g. temperature, salinity, depth, turbidity) which regulate its physiological activity, natural phenomena (climate change) and anthropogenic pressures. Meadows cover the majority of the Western Mediterranean coasts, but they are absent along parts of the Spanish coastline (Tarragona region), near the Ebro’s mouth, where freshwater input affects salinity and turbidity, thereby hindering seagrass growth 35. Similarly, along the French coasts between the Albères coastline and the Rhone River’s mouth (except for small beds in Cape d’Adge), considerable contributions of freshwater, suspended sediment and organic matter input do not allow P. oceanica to develop into meadows 36. Posidonia oceanica is also absent in Morocco (except for the Chafarinas Islands), probably due to the influence of cold Atlantic Water. In the Adriatic Sea, meadows are distributed along the eastern part (the coastline of Slovenia, Croatia, Montenegro and Albania) 37, the Apulian coasts 38 and small patches are present in Friuli (north-east of Italy) 39. In the North and Central-Western Adriatic Sea (Italian coasts of Abruzzi, Marche, Emilia and Veneto), inputs of suspended sediment and dissolved organic matter from the Po’s outlet, create high levels of turbidity along the central-western Adriatic coast, all the way until the Gargano Promontory. In the Levant Sea (Syrian, Lebanese and Israeli coastline), early reports of P. oceanica should be considered erroneous because meadows are not present in this area.