Pirinase Hayfever Relief Nasal Spray for Adults, Non-drowsy Hay Fever Medicine, Once a Day Dose x 60 Sprays

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Absorption: Following intranasal dosing of fluticasone propionate, (200 micrograms/day) steady-state maximum plasma concentrations were not quantifiable in most subjects (<0.01ng/mL). The highest Cmax observed was 0.017ng/mL. Direct absorption in the nose is negligible due to the low aqueous solubility with the majority of the dose being eventually swallowed. When administered orally the systemic exposure is <1% due to poor absorption and pre-systemic metabolism. The total systemic absorption arising from both nasal and oral absorption of the swallowed dose is therefore negligible.

They can be used to treat a range of conditions, including hay fever, sinusitis, non-allergic rhinitis and nasal polyps.The following medicines may slow the breakdown of any fluticasone that's absorbed into your bloodstream from your nose and so may increase the risk of side effects on the rest of the body: Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects known to be associated with Pirinase. Just because a side effect is stated here doesn't mean that all people using this medicine will experience that or any side effect. Very common Pirinase side effects Hypersensitivity reactions, anaphylaxis/anaphylactic reactions, bronchospasm, skin rash, oedema of the face or tongue If corticosteroid nasal sprays are used in high doses for long periods of time, they do have the potential to cause side effects similar to those associated with corticosteroids taken by mouth, such as Cushing's syndrome, adrenal suppression and mental health problems. However, these types of side effect are extremely unlikely to occur with this nasal spray, because the amount of fluticasone absorbed into the bloodstream from the nose is very low. As a precaution, the lowest effective dose needed to control your symptoms should always be used, and for the shortest possible time. Pirinase helps to relieve allergy symptoms for up to 24 hours. It can also help to prevent the return of symptoms during the day. Pirinase has a direct action to relieve allergy symptoms where they start.

concomitant use of other corticosteroid products, such as tablets, creams, ointments, asthma medications, similar nasal sprays or eye/nose drops You can usually drink alcohol while using a steroid nasal spray and you do not normally need to avoid any particular foods. Who can use steroid nasal sprays Steroid nasal sprays are normally safe to use while breastfeeding and during pregnancy, but it's a good idea to get medical advice first. How steroid nasal sprays work If your symptoms last for more than seven days despite using Pirinase, get medical advice from your doctor. The secretion of fluticasone propionate in human breast milk has not been investigated. Subcutaneous administration of fluticasone propionate to lactating laboratory rats produced measurable plasma levels and evidence of fluticasone propionate in milk. However, following intranasal administration to primates, no drug was detected in the plasma, and it is therefore unlikely that the drug would be detectable in milk. When this medicine is used in breast feeding mothers the therapeutic benefits must be weighed against the potential hazards to mother and baby.Lots of people think that nasal sprays are only for nasal symptoms-but with Pirinase this is not the case. Pirinase not only treats nasal symptoms but also the itchy, watery eyes and that congested feeling that are common symptoms of hay fever. Pirinase Hayfever Relief for Adults 0.05% Nasal Spray is used to treat the symptoms of hay fever. Pirinase is non-drowsy treatment for all major hay fever symptoms. No other hay fever medicine is more effective without prescription.* Pirinase is an intranasal corticosteroid (INCS) containing fluticasone propionate. This has an anti-inflammatory action and works in a similar way to natural body chemicals to control inflammation. This nasal spray for allergies helps control your body's reactions to airborne allergens in the environment, such as pollen, mould spores, pet dander or dust mites.

If you're taking a high dose for a long time, there's also a small chance you could get some of the side effects of steroid tablets, such as increased appetite, mood changes and sleeping problems (insomnia). Accidentally using too much steroid nasal spray is unlikely to be harmful. Speak to a pharmacist or doctor if you're worried. If you're taking a prescription spray, do not stop using it unless the doctor advises you to do so. Side effects of steroid nasal sprays cobicistat or protease inhibitors such as ritonavir for HIV infection (Pirinase nasal spray is not recommended for people who are taking ritonavir)

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Just one daily dose can provide unbeaten relief* from hay fever. Because Pirinase can last up to 24 hours, you don't need to carry it around, just spray once and you're ready for the day ahead.

Cataracts, raised pressure in the eye or glaucoma. Tell your doctor if you notice any changes in your vision while using Pirinase nasal spray. Metabolism: Fluticasone propionate is cleared rapidly from the systemic circulation, principally by hepatic metabolism to an inactive carboxylic acid metabolite, by the cytochrome P450 enzyme CYP3A4. Swallowed fluticasone propionate is also subject to extensive first pass metabolism. Care should be taken when co-administering potent CYP3A4 inhibitors such as ketoconazole and ritonavir as there is potential for increased systemic exposure to fluticasone propionate. Absorption: Following intranasal dosing of fluticasone propionate, (200 micrograms/day) steady-state maximum plasma concentrations were not quantifiable in most subjects (<0.01ng/mL). The highest C max observed was 0.017ng/mL. Direct absorption in the nose is negligible due to the low aqueous solubility with the majority of the dose being eventually swallowed. When administered orally the systemic exposure is <1% due to poor absorption and pre-systemic metabolism. The total systemic absorption arising from both nasal and oral absorption of the swallowed dose is therefore negligible. Treatment should be stopped or the advice of a doctor sought if an improvement is not seen within 7 days. The advice of a doctor or pharmacist should also be sought if symptoms have improved but are not adequately controlled. If symptoms are especially bad: 2 sprays twice a day and return to normal dose once symptoms improve.In an interaction study in healthy subjects with intranasal fluticasone propionate, ritonavir (a highly potent cytochrome P450 3A4 inhibitor) 100 mg b.i.d. increased the fluticasone propionate plasma concentrations several hundred fold, resulting in markedly reduced serum cortisol concentrations. Cases of Cushing's syndrome and adrenal suppression have been reported. Although not studied, concomitant use of intranasal fluticasone and cobicistat-containing regimens for the treatment of HIV may increase plasma concentrations of fluticasone and result in reduced serum cortisol concentrations.The combination of fluticasone and potent P450 3A4 inhibitors should be avoided unless the benefit outweighs the increased risk of systemic glucocorticoid side-effects. For hay fever, it's best to use them from 1 to 2 weeks before you think your symptoms will start, as they can take a few days to work. Some steroid nasal sprays are available to buy from pharmacies and shops, while others are only available on prescription. Steroid nasal drops are also available.