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Apigenin 100mg x 90 Capsules - Third Party Tested Over 98% - Natural Apigenin Supplement Vitality Pro

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Importantly, apigenin has estrogenic activity. Women with a history of estrogen-responsive cancers or on hormone replacement therapy should be especially cautious with apigenin and consult with their doctors before supplementing with this flavonoid [ 42, 43]. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Our team aims to be not only thorough with its research, but also objective and unbiased. Limited information on the absorption and distribution of apigenin glycosides can only be inferred from a couple of studies available. In the first one, purified flavonoid extract from parsley comprised a mixture of glycosides of the flavones: apigenin, luteolin and chrysoeriol, and of the flavonols: kaempferol, quercetin, and isorhamnetin were administrated to rats by gavage [ 37]. The dose corresponded to 6.9 mg aglycones per kg body mass. Glycosides were detected by HPLC in the wall and the lumen of the stomach, the wall of the small intestine after 1 hour and 4 hours as well as the cecum wall after 4 hours; however, no concentration values were provided and the glycosides were a mixture of different flavonoids. The apigenin aglycone was detected in the lumen of the small intestine after 1 and 4 hours at the concentrations of 855.59 μg/gram dry matter and 207.05 μg/gram dry matter, respectively; the concentration in cecum after 4 hours was 353.38 μg/gram dry matter. The concentrations of apigenin aglycone in the wall of the stomach, the small intestine, and the cecum were much lower, 16.27 μg/gram dry matter in the stomach wall after 4 hours and 12.58 μg/gram dry matter in the cecum wall. No apigenin was detected in the small intestine wall at either time points. As the treatment comprised of a mixture of flavonoids, the exact source of the apigenin detected was not able to be determined. Nevertheless, as can be seen from the results, the glycosides transported to the cecum were mostly absorbed or deglycosylated rapidly as the cecum luminal contents flavonoids contained only aglycones. Therefore, when studying the impact of dietary apigenin in the colon by in vitro simulation, such as when using bioreactors to culture gut microbiota, the treatment group should use apigenin, the aglycone form, rather than naturally present glycosides. In another study, three groups of rats received Apigenin-7- O- β-D-glucoside solution via tail vein injection at a single dose of 27.0, 18.0, or 9.0 mg/kg [ 69]. Plasma level of Apigenin-7- O- β-D-glucoside was measured over the course of 5 hours after drug administration. Estimated plasma concentrations of Apigenin-7- O- β-D-glucoside based on the figure were about 1, 0.65, and 0.5 μg/gram right after the injection, and decreased to about 0.3, 0.25, and 0.38 μg/gram after one hour for each group.

We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Noroozi M, Angerson WJ, Lean ME Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes. Am J Clin Nutr. (1998-Jun) In mice, topical apigenin improved skin permeability barrier function by promoting skin cell growth and the production of fatty molecules and antimicrobial proteins. This suggests it may help with conditions characterized by permeability barrier dysfunction such as atopic dermatitis [ 7]. Demystify scientific studies. Develop the skill to sift through the jargon and make empowered decisions for your health. Decreased release of pro-inflammatory messengers (nitric oxide and PGE2) and cytokines ( TNF-α, IFN-γ, IL-2, Th1 cytokines) [ 18, 19]All the current research suggests that Apigenin is safe, even at doses exceeding what you would usually require through diet alone. However, if you experience any sort of digestive issues or irritations following ingesting, you should stop using the product. Speak to a healthcare professional before using Apigenin to treat a condition. Can women take Apigenin?

During A, Larondelle Y The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: Structure-activity relationships of flavones. Biochem Pharmacol. (2013-Dec-15) Research on apigenin first began in the 1960s, and it was proposed to be chemo-preventative in the 1980s [ 9, 13, 51]. Recently, apigenin has received much attention because it has low intrinsic toxicity [ 4, 44] and it exerts differential effects on normal versus cancer cell growth, survival, or apoptosis in several different types of cells [ 9, 13, 52]. Sun Y, Zhao R, Liu R, Li T, Ni S, Wu H, Cao Y, Qu Y, Yang T, Zhang C, Sun Y Integrated Screening of Effective Anti-Insomnia Fractions of Zhi-Zi-Hou-Po Decoction via and Network Pharmacology Analysis of the Underlying Pharmacodynamic Material and Mechanism. ACS Omega. (2021-Apr-06) The anti-diabetic properties of apigenin may be attributed to its capacity to inhibit α-glucosidase activity, increase secretion of insulin [ 107], to interact with and neutralize reactive oxygen species (ROS) in the cell [ 108], which together contribute to the prevention of diabetic complications [ 109]. Apigenin has also shown the ability to supply moderate nitric oxide (NO) to endothelial cells, thereby limiting the risk of endothelial cell injury and dysfunction from hyperglycemia [ 109].

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Patel D, Shukla S, Gupta S Apigenin and cancer chemoprevention: progress, potential and promise (review). Int J Oncol. (2007-Jan) Since apigenin is widely distributed in food items, and a diet high in flavonoids has been reported with many beneficial health effects, an estimation of the daily intake of apigenin could be useful in the correct interpretation of the relationship between health outcomes and apigenin. Though dietary intake values have been obtained for some individual flavonoids [ 21], when it comes to the flavone, apigenin, relevant research is very limited [ 22, 23]. Higher estimation of daily dietary intake of flavonoids is 1 g as glycosides or 650 mg as aglycones [ 24], while another study estimated an average of only 23 mg/day in adults in the Netherlands [ 12]. In a study around 1990, the mean flavanol and flavone intake among US health professionals was approximately 20-22 mg per day [ 25]. In the aforementioned study in the Netherlands in 1988, most of the average daily intake was attributed to quercetin, about 16 mg/day, and the actual daily intake of apigenin was only about 0.69 mg/day [ 12]. However, another study on the Dutch diet estimated that the average daily intake of apigenin is about 1 mg [ 22]. A similar number, 1.5 ± 4.9 mg/day (range 0-30.3), was reported in a group of female Flemish dietitians [ 23]. A more recent paper provided information on the mean intake of flavonoid compounds in adults in the European Union by country, region, and overall [ 26]. The European average of apigenin intake is 3 ± 1 mg/day using the food consumption data from the European Food Safety Authority (EFSA) and the FLAVIOLA Food Composition Database. The daily intake level of apigenin is 4.23 mg/day in China [ 27], while among middle-aged and older women in the US, it is 0.13–1.35 mg/d [ 28]. This intake value among US women is similar to the reported 0.2-1.3 mg/day among 66,940 married women in a US nurses’ health study from 1984 through 2002 [ 29]. By measuring the intake of apigenin from major dietary sources of flavones in adult Australians, the mean daily intake value was determined to be 0.45 mg/day [ 30]. eBASIS represents the first EU harmonized food composition database, containing composition data and biological effects of over 300 major European plant foods of 24 compound classes in 15 EU languages [ 156]. It is based on the compilation of critically evaluated data from peer-reviewed literature, inserted as raw data. Currently, there are 1039 composition data points in eBASIS for flavones, including data for apigenin as its aglycone and as apigenin glycosides [ 154, 156]. Data for beneficial effects cover in vitro, in cell, and in vivo studies.

The bioflavonoid has gained attention after researchers reported on its low toxicity and beneficial bioactivities. Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F, Medina JH, Paladini AC Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med. (1995-Jun)Apigenin-treated mice showed improved memory, learning, and activity of the brain cell-birth BDNF pathway [ 34]. Hollman PC, Katan MB Health effects and bioavailability of dietary flavonols. Free Radic Res. (1999-Dec) Gaur K, Siddique YH Effect of apigenin on neurodegenerative diseases. CNS Neurol Disord Drug Targets. (2023-Apr-06)

In clinical trials, adverse effects were rare and mild. They included digestive discomfort (oral chamomile extract) and skin reactions (topical chamomile gel). Because the trials didn’t use pure apigenin, these effects could have been caused by any other chamomile compounds [ 41, 11]. What do chamomile, oranges and beer have in common? They each provide the flavonoid apigenin, which has powerful antioxidant and anti-inflammatory effects.Pure apigenin is generally regarded as unstable for long term storage at room temperature, and thus it requires storage at -20°C [ 9]. For use in experiments, it is recommended that fresh solutions be made as needed [ 32]. Some researchers have investigated the stability of apigenin under various conditions. After heated reflux in water for 30 min, maceration for 24 hours or microwave irradiation for 5 min under 500 W, 93-95% of apigenin was recovered for each condition [ 33]. However, ultrasonic extraction caused the product to be degraded with only an 86% recovery rate [ 33]. Another study showed that, in rat plasma in vitro, apigenin was stable under three conditions: 24 hours under room temperature, at least 4 weeks when kept frozen at -20°C, and after at least three freeze-thaw cycles [ 40, 41]. Shoara et al. [ 104] conducted a randomized controlled clinical trial on the efficacy and safety of apigenin-rich chamomile oil for knee osteoarthritis. A treatment with topical chamomile oil three times/day for three weeks significantly reduced the demand of analgesic (acetaminophen) of patients with knee osteoarthritis, improving their physical function. As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, Excretion of apigenin after oral intake through feces is a good indication of the phenomenon that dietary apigenin is available for metabolism by the gut microbiota. In one of the aforementioned experiments in Section 5.1 using rats, after a single oral administration of radiolabeled apigenin, 51.0% of the radioactivity was recovered in urine and 12.0% in feces within 10 days. In the same research, it was discovered that sex and age of the rats affected apigenin conjugates eliminated via the urinary route [ 59]. That research also concluded that apigenin has a slow metabolism and a slow elimination phase. Thus, this flavonoid possibly accumulates in the body [ 59]. 5.5. Apigenin Glycosides Li W, Dai RJ, Yu YH, Li L, Wu CM, Luan WW, Meng WW, Zhang XS, Deng YL Antihyperglycemic effect of Cephalotaxus sinensis leaves and GLUT-4 translocation facilitating activity of its flavonoid constituents. Biol Pharm Bull. (2007-Jun)

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