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Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.

When used as a single agent, monalizumab also improved CD107 expression by NKG2A + PD-1 + NK cells cocultured with K562-HLA-E targets.Here, we show that NKG2A blockade enhances the anti-tumor immunity mediated by NK and CD8 + T cells. A. NKTR-214, an engineered cytokine with biased IL2 receptor binding, increased tumor exposure, and marked efficacy in mouse tumor models.

Single-stage glanded centrifugal pump with compact in-line design with directly flanged three-phase motor and one-piece shaft or with lantern and standard motor rigidly connected by coupling (N version). The CD14-negative fraction was retained for the isolation of CD8 + T cells with a CD8 + T cell negative selection kit. Female mice were used at eight to 12 weeks of age and were allowed to acclimate to the housing facility for at least one week. We used a one-stage Fleming design with futility analysis after the first 11 patients; the overall phase II study will include 40 patients. Cells from WB (whole blood, n = 23), LN (normal lymph node, n = 6), meta LN (metastatic lymph node, n = 12), adj (healthy tissue adjacent to the tumor, n = 8), and tumor (n = 13) were analyzed by flow cytometry.Another advantage of targeting NKG2A is the safety of this approach, as no abnormalities have been reported in mouse strains lacking CD94 ( Vance et al.

F. Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma. Following their subcutaneous injection into syngeneic BALB/c mice, wild-type A20 B cell lymphoma cells progressively grew in all mice ( Figure 1A, left panel). In healthy individuals, around 5% of human peripheral blood CD8 + T cells express cell-surface NKG2A at steady state, but this expression can be upregulated by chronic antigenic stimulation ( Bertone et al. mg/kg every 2 weeks) in combination with the approved dosage of cetuximab (400 mg/m 2 load then 250 mg/m 2 weekly) were explored.If the Maximum Tolerated Dose (MTD) was not reached, monalizumab would be tested in the phase II part at a dose of 10 mg/kg.