Vitamin B3 Nicotinamide (Niacinamide) 500mg 180 Capsules (V) Vegan. No-Flush Niacinamide. Made in The UK by Health4All

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Ultraviolet radiation ( UVR) is the main risk factor for skin cancer development. The mechanisms by which UVR leads to cancer are complex including direct damage to DNA and effects on the immune system. Nicotinamide has been shown to enhance the repair of direct and oxidative DNA damage in human keratinocytes and human skin. It has the potential to prevent UV-induced immune suppression, shown in a study of volunteers with a positive Mantoux test (positive tuberculin sensitivity test). The Mantoux reaction can be suppressed by exposure to UVR. Nicotinamide reduced this immune suppression when it was applied either before or after exposure to UVR (simulating sunlight exposure). Hussain S, Singh A, Alshammari TM, et al. Nicotinamide therapy in dialysis patients: a systematic review of randomized controlled trials. Saudi J Kidney Dis Transpl. 2020;31(5):883-897. doi:10.4103/1319-2442.301195.

Nicotinamide Prevents Common Skin Cancers in High-Risk Oral Nicotinamide Prevents Common Skin Cancers in High-Risk

Raines NH, Ganatra S, Nissaisorakarn P, et al. Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study. Kidney360 2020;2(1):33-41. View abstract. Nonmelanoma skin cancer. Taking niacinamide by mouth seems to help prevent new skin cancer or precancerous spots from forming in people with a history of nonmelanoma skin cancer. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs.The investigators emphasized that these results were achieved in individuals who previously had skin cancer and were thus at high risk for new skin cancers. The results do not apply to other patient populations.

British Association of Dermatologists

A large study found that taking nicotinamide can reduce the risk of getting certain types of skin cancers. A few small studies suggest it may also reduce the occurrence of rough scaly patches. Additional long-term studies are needed. Falsini, B., Piccardi, M., Iarossi, G., Fadda, A., Merendino, E., and Valentini, P. Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessment. Ophthalmology 2003;110(1):51-60. View abstract. Ketteler M, Wiecek A, Rosenkranz AR, et al. Efficacy and Safety of a Novel Nicotinamide Modified-Release Formulation in the Treatment of Refractory Hyperphosphatemia in Patients Receiving Hemodialysis-A Randomized Clinical Trial. Kidney Int Rep 2020;6(3):594-604. View abstract.Niren NM. Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review. Cutis. Jan 2006;77(1 Suppl):11-16. Mainville L, Smilga AS, Fortin PR. Effect of nicotinamide in skin cancer and actinic keratoses chemoprophylaxis, and adverse effects related to nicotinamide: a systematic review and meta-analysis. J Cutan Med Surg. 2022;26(3):297-308. doi:10.1177/12034754221078201. Hui F, Tang J, Williams PA, et al. Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial. Clin Exp Ophthalmol. 2020 Sep;48(7):903-914.