Yves Saint Laurent Black Opium Extreme Eau de Parfum Extreme 50ml, (Pack of 1)

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S. Mercadante (1998). "Oral morphine consumption in Italy and Sicily". Journal of Pain and Symptom Management. 15 (4): 227–30. doi: 10.1016/S0885-3924(98)00368-6. PMID 9601157.

Meadway C, George S, Braithwaite R (August 31, 1998). "Opiate concentrations following the ingestion of poppy seed products—evidence for 'the poppy seed defence' ". Forensic Science International. 96 (1): 29–38. doi: 10.1016/S0379-0738(98)00107-8. PMID 9800363. Musto, David F. The American Disease: Origins of Narcotic Control. New York: Oxford University Press, 1987. So I stayed away from it. When I found out that YSL came out with the Extreme version with "dialed-up" coffee and cacao notes, I decided to give it a try. And I gotta say- it's a very nice fragrance! E. Guerra Doce (January 1, 2006). "Evidencias del consumo de drogas en Europa durante la Prehistoria". Trastornos Adictivos (in Spanish). 8 (1): 53–61. doi: 10.1016/S1575-0973(06)75106-6. Archived from the original on May 15, 2008 . Retrieved May 10, 2007. (includes image) John Richards (May 23, 2001). "Opium and the British Indian Empire" . Retrieved September 24, 2007.For the illegal drug trade, the morphine is extracted from the opium latex, reducing the bulk weight by 88%. It is then converted to heroin which is almost twice as potent, [6] and increases the value by a similar factor. The reduced weight and bulk make it easier to smuggle.

I'm sorry but to me this has become way too far from what I consider perfume. I'm not against fusion of things, I do like gourmand fragrances. However, I think it was gone too far. It's like we're talking about cakes and all sorts of confectionary but not real perfumes. Both analgesia and drug addiction are functions of the mu opioid receptor, the class of opioid receptor first identified as responsive to morphine. Tolerance is associated with the superactivation of the receptor, which may be affected by the degree of endocytosis caused by the opioid administered, and leads to a superactivation of cyclic AMP signaling. [155] Long-term use of morphine in palliative care and the management of chronic pain always entails a risk that the patient develops tolerance or physical dependence. There are many kinds of rehabilitation treatment, including pharmacologically based treatments with naltrexone, methadone, or ibogaine. [156] hour later, it starts to lose quite a bit of it's sweetness and it's more of a lightly sweet vanilla with some dark richness to it. A touch more cacao and coffee to the scent. It's like a chocolate cappuccino maybe? It's very nice, cozy, and comforting smelling, and I really imagine fall and winter with it. This is also where I see it start to be a bit more "masculine," but honestly it's completely fine on a woman and is more perhaps "edgy". Projection has gone down to about 1" from my skin, but still some sillage and light projection a bit beyond that. This is already outperforming the original (and pretty much all of its flankers), which after about 30 minutes, would be basically gone on me. I lightly tested this the day I got it and the scent lingered as a skin scent of vanilla and patchouli for hours after, so I was very impressed. Bradley, James (2009). The Imperial Cruise: a secret history of empire and war. Little, Brown and Company. pp. 274–275. ISBN 978-0-316-00895-2.Between 400 and 1200 CE, Arab traders introduced opium to China, and to India by 700. [19] [1] [12] [20] The physician Muhammad ibn Zakariya al-Razi of Persian origin ("Rhazes", 845–930 CE) maintained a laboratory and school in Baghdad, and was a student and critic of Galen; he made use of opium in anesthesia and recommended its use for the treatment of melancholy in Fi ma-la-yahdara al-tabib, "In the Absence of a Physician", a home medical manual directed toward ordinary citizens for self-treatment if a doctor was not available. [21] [22]