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PIHKAL: A Chemical Love Story

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Shortly after gaining traction in the underground psychotherapy community, 2C-B became popular in the recreational drug scene. It was well-liked as a MDMA substitute in raves and club parties due to its minimal comedown and a clear, euphoric headspace. B was discovered in 1974 by the American chemist Alexander Shulgin, who was investigating psychedelic phenethylamines derived from mescaline. [2] [3] Through PIHKAL (and later TIHKAL), Shulgin sought to ensure that his discoveries would escape the limits of professional research labs and find their way to the public, a goal consistent with his stated beliefs that psychedelic drugs can be valuable tools for self-exploration. The MDMA ("ecstasy") synthesis published in PIHKAL remains one of the most common clandestine methods of its manufacture to this day. Many countries have banned the major substances for which this book gives directions for synthesis, such as 2C-B, 2C-T-2, and 2C-T-7. In the United Kingdom, all but phenethylamine are illegal. [ citation needed] Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them). B (Nexus) Reappears on the Club Drug Scene" (PDF). Information Bulletin. Drug Enforcement Agency (DEA). May 2001. 2001-L0424-002.

The second part was made freely available by Shulgin on Erowid while the first part is available only in the printed text. While the reactions described are beyond the ability of people with a basic chemistry education, some tend to emphasize techniques that do not require difficult-to-obtain chemicals. Notable among these are the use of mercury-aluminum amalgam (an unusual but easy to obtain reagent) as a reducing agent and detailed suggestions on legal plant sources of important drug precursors such as safrole. This book is utterly amazing. The first half is a very endearing sort of dual biography from Alexander and Ann Shulgin, and the second half is a description of quite a number of substances created and/or tested by the Shulgins and friends. principle neurotransmitters in the brain are dopamine (a phenethylamine)(ex. Mescaline, MDMA) and seratonin (a tryptamine)(ex. Mushrooms, DMT, LSD) I'll sign off this review with a transcript of the picture above, because I know that sometimes food is best eaten pure.PLUS / MINUS (+/-) The level of effectiveness of a drug that indicates a threshold action. If a higher dosage produces a greater response, then the plus/minus (+/-) was valid. If a higher dosage produces nothing, then this was a false positive. In the United States, it gained popularity as an alternative to MDMA after the latter was classified as a Schedule I substance in 1985. The increasing popularity of 2C-B led to it also being placed in Schedule I in 1995. [5] It saw a resurgence in interest in the 2000s, with the advent of the "research chemicals"/"designer drugs" scene and darknet markets. Along the same lines as Huxley, Dr. Shulgin has opened doors for me. If it weren't for these authors I never would have even begun to appreciate organic chemistry. Its nuances, its complexity. Brazil: 2C-B is illegal to possess, produce and sell in Brazil as it is listed on Portaria SVS/MS nº 344. [25] Tolerance to the effects of 2C-B is not built almost immediately after ingestion. There are many anecdotal reports of people ingesting this substance many days in a row (either consecutively or by redosing many many times in a row and tripping continuously for dozens of hours) with no immediate tolerance build up and still building quite slowly even under sustained exposure.

Shulgin considered 2C-B to be one of his greatest inventions; it was one of the six psychedelic molecules among his “magic half dozen,” which he thought had the most potential (and five of which he invented himself). He’s also claimed 2C-B to be one of his all-time favorite psychedelics, which is significant for a scientist who’s gone on around 10,000 psychedelic trips. “It is, in my opinion, one of the most graceful, erotic, sensual, introspective compounds I have ever invented,” he wrote in his “Ask Dr. Shulgin” column in 2003. “For most people, it is a short-lived and comfortable psychedelic with neither toxic side effects nor next-day hangover.” The first part of the book is Dr. Shulgin's own personal story as well as that of his wife and their friends and colleagues who helped out in the experimentation with phenethylamines. I'm not sure exactly how much is attributable to artistic license and how much is truthful. I believe it's "officially" fictional. Self incrimination and all...Alexander Shulgin; Ann Shulgin (1991). "#20. 2C-B". PiHKAL: A Chemical Love Story. United States: Transform Press. ISBN 0963009605. OCLC 1166889264. Like LSD, while 2C-B is capable of producing a full range of low and high-level hallucinatory states, they are comparatively rare and inconsistent at higher levels while common at lower levels. They generally include the following effects: Sometimes you read some books you think everybody should read, if only just so that they can correct their misconceptions on certain things. The final chapter is a John Galt-like argument for the legalization and use of psychedelic drugs and a more libertarian approach to freedom with some light warnings against the slippery slope of government control. This is Shulgin at his most passionate.

Appetite suppression - While not as intense as stimulants such as MDMA, most doses can cause a decrease in appetite.While reading this book I attended a lecture given by Nobel laureate Kary Mullis. Kary Mullis received the Nobel Prize for Chemistry in 1993 for the development of PCR. During his lecture he commented on the first scientific paper he published in Nature, in 1968. He described it as a sophomoric astrophysical hypothesis called "The Cosmological Significance of Time Reversal." He told the audience he ate LSD while writing it. Needless to say Nature is still probably a little embarrassed about publishing it. TiHKAL is divided into two parts. The first part, for which all rights are reserved, begins with a fictionalized autobiography and then continues with a collection of essays on topics ranging from psychotherapy and the Jungian mind to the prevalence of DMT in nature, ayahuasca, and the War on Drugs. The second part of TiHKAL, which may be conditionally distributed for non-commercial reproduction, is a detailed synthesis manual for 55 psychedelic compounds (many discovered by Alexander Shulgin himself), including their chemical structures, dosage recommendations, and qualitative comments.

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