PectaSol Modified Citrus Pectin Powder Super-Nutrient to Support Cellular & Immune Health, Joint Support - 454 Grams - Formulated by Dr. Isaac Eliaz of ecoNugenics

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According to a fast-growing body of published data, a major target has been found. More than 8000 studies show that the carbohydrate binding protein, galectin-3 (Gal-3), serves as a primary therapeutic target for the prevention and treatment of our most critical conditions, effectively meeting this growing demand in chronic disease management. L. Calvier, et al., “The Impact of Galectin-3 Inhibition on Aldosterone-Induced Cardiac and Renal Injuries,” JACC Heart Fail. 3(1), 59–67 (2015). M. Azémar, et al., “Clinical Benefit in Patients with Advanced Solid Tumors Treated with Modified Citrus Pectin: A Prospective Pilot Study,” Clinical Med. Oncol. 1: https://doi.org/10.4137/CMO.S285 (2007). What’s more, MCP also lowered the rate of acute kidney injury, which went from 89% in the control group to 44% in both groups taking the modified pectin [ 14]. Improving Cognition

Abstract 4918: Modified citrus pectin slows migration of

Glinsky, V. V., Kiriakova, G., Glinskii, O. V., Mossine, V. V., Mawhinney, T. P., Turk, J. R., et al. (2009). Synthetic galectin-3 inhibitor increases metastatic cancer cell sensitivity to taxol-induced apoptosis in vitro and in vivo. Neoplasia 11, 901–909. What is POTS (postural orthostatic tachycardia syndrome)? Here’s a breakdown of symptoms, diagnostic criteria—and what can be done to treat it. Natural pectin is something that we’re all familiar with, even if we don’t know what it’s called. This is the spongy pulp found in the peels of citrus fruits such as oranges, limes, lemons, and grapefruit, as well as in apples and plums. Ried K, Eng P, Sali A. Screening for circulating tumour cells allows early detection of cancer and monitoring of treatment effectiveness: an observational study. Asian Pac J Cancer Prev. 2017 Aug 27;18(8):2275–85. DOI: 10.22034/APJCP.2017.18.8.2275. PMID: 28843267. PMCID: PMC5697492.George T, Brady MF. Ethylenediaminetetraacetic Acid (EDTA). In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. PMID: 33351441. Also, in another small clinical study involving 13 men with prostate cancer who were resistant to surgery, radiation, and cryotherapy, treatment results showed that in 70% of the men, taking MCP for 12 months increased the time it took for the PSA numbers to double from baseline. This suggests that the tumor growth progressed significantly more slowly than it would otherwise [ 10]. J. Jiang, I. Eliaz and D. Sliva, “Synergistic and Additive Effects of Modified Citrus Pectin with Two Polybotanical Compounds in the Suppression of Invasive Behavior of Human Breast and Prostate Cancer Cells,” Integr. Cancer Ther. 12(2), 145–152 (2013). As mentioned here above, the role of the components of the plant cell wall is first to give mechanical solidity and to form a barrier from the external environment. HGs and RGII are known to be responsible for the wall rigidification. HGs have the property to form structures which are named “egg boxes.” Two HG chains are bound one to the other through interactions including bivalent Ca 2 + ions intercalated in between them ( Liners et al., 1989). This process is important for the gelling of pectin.

PectaSol-C (Modified Citrus Pectin) 454g – ecoNugenics

The original and only proven effective form of MCP is prepared with a proprietary, non-GMO enzymatic process controlled by pH and heat, which breaks the long chain molecules of the native pectin to produce the correct molecular size and structure of <13 kilodaltons and <5% esterification. With over 75 published studies, PectaSol-C® Professional is the original and only proven form of modified citrus pectin, derived from citrus pith and modified to precise molecular weight and structure. This specialized modification process ensures bioavailability via absorption into the circulation, and gives PectaSol-C professional its’ broad-spectrum bioactivity resulting in systemic benefits for healthy cell, tissue, and organ function.* Sathisha, U. V., Jayaram, S., Harish Nayaka, M. A., and Dharmesh, S. M. (2007). Inhibition of galectin-3 mediated cellular interactions by pectic polysaccharides from dietary sources. Glycoconj. J. 24, 497–507. doi: 10.1007/s10719-007-9042-3Guess, B. W., Scholz, M. C., Strum, S. B., Lam, R. Y., Johnson, H. J., and Jennrich, R. I. (2003). Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study. Prostate Cancer Prostatic Dis. 6, 301–304. doi: 10.1038/sj.pcan.4500679 From driving proinflammatory, profibrotic and procancerous pathways to promoting immune evasion, metabolic dysfunction and blood-brain barrier permeability, Gal-3 plays such a fundamental role that some experts are calling for a new category of health conditions: Elevated Galectin-3 Diseases. While research is preliminary, modified citrus pectin has the potential to offer benefits for heart disease, cancer, IBS, and even cognition. It may also act as a natural chelating agent, helping individuals to safely detoxify from heavy metals. O’Brien, S., and Kay, N. E. (2011). Maintenance therapy for B-chronic lymphocytic leukemia. Clin. Adv. Hematol. Oncol. 9, 22–31. On the other hand, colonocyte apoptosis activation in animals fed with pectin is also largely due to butyrate, a molecule coming from pectin fermentation by colon bacteria flora ( Avivi-Green et al., 2000a, b). Indeed, intracolonic instillation of butyrate recapitulates the effect of orally administered pectin ( Avivi-Green et al., 2000b). Butyrate is also able to induce apoptosis in colonocytes in vitro in a p53-independent manner ( Kolar et al., 2007) and by inducing mitochondrial Ca 2+ overload ( Kolar et al., 2011). In parallel, both in vitro in rat intestinal epithelial cells exposed to butyrate and in mice fed with a diet supplemented with 20% pectin, TGF-ß signaling has been demonstrated to be enhanced, leading to colonocyte growth inhibition and apoptosis. Apoptosis seems to be induced via an increased expression of Id2 (inhibitor of differentiation 2), probably via inhibition of selective isoforms of HDACs ( Cao et al., 2011). Anti-Tumor Activity of pH-Modified Pectin

Modified citrus pectin inhibits breast cancer development in Modified citrus pectin inhibits breast cancer development in

Brouns F, Theuwissen E, Adam A, Bell M, Berger A, Mensink RP. Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. Eur J Clin Nutr. 2012 May;66(5):591–9. DOI: 10.1038/ejcn.2011.208. PMID: 22190137.

We now understand that as a culprit biomarker, extracellular Gal-3 functions as a key driver behind the development and progression of metastatic cancer, cardiovascular disease, organ fibrosis, neurodegenerative disease, immune dysregulation, premature ageing and many other conditions.