Broccoli Sprout Extract by LLS | Contains Activated Sulforaphane | 60 Capsules | 18,000mg of Whole Plant Equivalent per Serving | Sulforaphane Supplement | Potent Antioxidant Content

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Typically, cruciferous vegetables are not consumed immediately after harvesting. Therefore, the storage and processing of such vegetables have a significant impact on glucosinolate content and the health benefit of consumption ( Björkman et al., 2011; Barba et al., 2016). This is variable depending on the cultivar, plant tissue, and growth stage of the plant ( Galgano et al., 2007). Freezing has been shown to result in higher retention of glucosinolates compared to refrigeration. Storage of broccoli at 6°C for 35days resulted in a sulforaphane loss of 29%, compared to losses of approximately 13% after freezing at −18°C for 60days. Moreover, the reduction in glucosinolates measured after freezing was associated with steam-blanching prior to freezing ( Galgano et al., 2007). Storage in darkness has been shown to decrease the content of aliphatic glucosinolates ( Casajús et al., 2020).

Colon cancer incidence is heavily associated with dietary habits; diets rich in red meat are associated with an increased risk, whilst those high in fruit and vegetables are associated with a reduced risk ( Veettil et al., 2021). In human colon cancer cell lines, HCT116 and SW480, sulforaphane diminished cell growth in a dose-dependent way, and increased apoptosis induced by Lactobacillus through the TNF α pathway ( Yasuda et al., 2019). Sulforaphane treatment also led to suppression of key colorectal cancer stem cell markers, such as CD44 and CD133 in HCT116 and SW480 spheroids, facilitated by the TAp63 α/Lgr5/ β-catenin pathway ( Chen et al., 2020), suggesting that exposure to sulforaphane could lead to lowered cell proliferation activity. On the contrary, sulforaphane treatment (<10µM) led to increased cell proliferation and also lowered expression of key apoptotic proteins Bcl-2 and Bax, but concentrations of greater than 10µM caused cell death in p53-wild-type HCT116 cells ( Wang et al., 2021). There are few animal or human studies that have assessed the role of sulforaphane on colon cancer. However, Suzuki and coworkers found that sulforaphane intake led to reduced development of microscopic aberrant crypt foci and macroscopic tumors in mice or patients with colon cancer ( Suzuki et al., 2019), suggesting that consumption of broccoli could prevent colon cancer progression. Conclusion and Future Directions Zhang Z, Atwell LL, Farris PE, Ho E, Shannon J. Associations between cruciferous vegetable intake and selected biomarkers among women scheduled for breast biopsies. Public Health Nutr. 2016;19(7):1288-1295. doi:10.1017/S136898001500244XFrom seed to harvest, broccoli can take anywhere from 60 to 150 days to grow, depending on environmental temperature and broccoli type.

Seasonal variation in glucosinolate content has been recorded, with the majority of studies indicating that plants with the highest glucosinolate concentration are typically grown in spring in intermediate temperatures with high light intensity, longer days, and dry conditions ( Björkman et al., 2011). However, there is variation among plants and exceptions to this. The diurnal cycle may also impact the glucosinolate profile of cruciferous vegetables. For example, Casajús and coworkers found that glucosinolate levels were optimized during postharvest storage if broccoli were harvested close to noon ( Casajús et al., 2020).Place the capsule in your mouth with enough water and tilt your head slightly forward towards your chest. Even if you Despite these promising findings, more research is needed to determine whether sulforaphane could improve heart health in humans. May Have Antidiabetic Effects When considering the role of glucosinolates for musculoskeletal health, sulforaphane has been studied most extensively in animal models. Historically, the understanding of the effects of glucosinolates on skeletal muscle comes from trials of their application in animal production settings, with results indicating that although growth performance may be affected, muscle had an improved antioxidant status and fatty acid profile ( Drażbo et al., 2019; Skugor et al., 2019). When sulforaphane was provided to male Wistar rats for 3days prior to performing exhaustive exercise, sulforaphane served as an indirect antioxidant in skeletal muscle, as measured by decreased tissue total antioxidant capacity in the vastus lateralis muscle. It was concluded that sulforaphane plays a vital role in modulating the muscle redox environment; ultimately creating favorable effects on muscle ( Malaguti et al., 2009). It was reported that type 2 diabetic mice receiving sulforaphane injections over 4week had greater grip strength, lean mass, and gastrocnemius mass ( Wang M. et al., 2020). These diabetic mice also presented with improved skeletal muscle fiber organization after sulforaphane treatment. It was proposed that sulforaphane may downregulate the expression of inflammatory and apoptotic associated proteins. Sulforaphane was also suggested to play a role in regulating mRNA levels of anti-inflammatory and oxidative related genes. Collectively, it was concluded that sulforaphane treatment could be protective against skeletal muscle disease in mice with type 2 diabetes. A poor diet with low amounts of fruits, vegetables, whole grains, seeds, and nuts, and excessive consumption of foods such as ultra-processed grains and sugar-sweetened beverages is the leading contributor to chronic disease risk ( Afshin et al., 2019). There is increasing evidence that higher consumption of fruit and vegetables plays a central role in the prevention of non-communicable diseases ( Liu, 2013). Vegetables contain a variety of different compounds that have beneficial health effects, including fiber, vitamins, minerals, and phytochemicals. Research has shown that some types of vegetables may have greater health benefits than others for certain health conditions, such as diabetes, cardiovascular disease, and cancer ( Cooper et al., 2012; Aune et al., 2017). This may be due to the presence of unique bioactive phytochemicals with potent health-related effects. Therefore, targeted recommendations surrounding the intake of specific types of vegetables with protective health benefits could assist in the reduction of non-communicable diseases.

Broccoli and broccoli extract contain two vital nutrients for cognition and memory: vitamin K and choline. Vitamin K is in very few foods, but it’s key to maintaining healthy brain function, and may even prevent diseases like dementia and Alzheimer’s (x). But too much inflammation can affect the whole body, impairing circulation, digestion, cognition and many other necessary functions. It can cause a great deal of pain, and sometimes there’s no known cause for it.

ORIGINAL RESEARCH article

Current epidemiological evidence suggests that cruciferous vegetables play a key role in muscle and bone health, possibly due to the presence of glucosinolates and isothiocyanates. For example, in a large cohort of older community-dwelling women ( n= 1,468, ≥70years), women with the highest cruciferous (>44g/day) and allium (>11g/day) vegetable intake had 28 and 34% lower relative hazards for a fracture-related hospitalization over 14.5years, respectively ( Blekkenhorst et al., 2017b). Similarly, greater cruciferous and allium vegetable intake was associated with 22 and 26% lower relative hazard ratio for an injurious fall-related hospitalization over this time, respectively ( Sim et al., 2018). Although not specifically examining the role of glucosinolates, these studies demonstrate the potential importance of a diet rich in glucosinolates for musculoskeletal health. Muscle Myrosinase enzymes are only released and activated when a plant is damaged. Therefore, cruciferous vegetables must be cut, chopped, or chewed to release myrosinase and activate sulforaphane ( 1). WM has previously received funding from the NHMRC, Clifford Craig Foundation, Cancer Council Queensland and university grants/fellowships from La Trobe University, Deakin University, University of Queensland, and Bond University, received industry funding and has attended events funded by Cobram Estate Pty. Ltd., received travel funding from Nutrition Society of Australia, received consultancy funding from Nutrition Research Australia, and has received speakers honoraria from The Cancer Council Queensland and the Princess Alexandra Research Foundation. NT has received funding from Deakin University for an Executive Dean’s Post-Doctoral Fellowship. Despite their growing popularity, more research is needed to determine the ideal dose, safety, and effectiveness of sulforaphane supplements in humans ( 14). Summary