The Official Pokemon HeartGold and SoulSilver Johto Guide and Johto Pokedex

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As with FireRed & LeafGreen, after you have earned all the Kanto badges, you will gain access to the Cerulean Cave. Deep within the cave, like in FireRed & LeafGreen, you will find Mewtwo. It is at Level 70 so be sure to bring your strongest Pokémon. Mewtwo

Ecruteak City and Cianwood City, while sharing a theme in Generation II, now feature separate remixed variations of the same theme. The foe is scared off, to be replaced by another Pokémon in its party. In the wild, the battle ends.Articuno, Zapdos, and Mewtwo can be found in their original areas, while Moltres is now located in Mt. Silver. Musique de Sinnoh : Antre Noir, Cave Taupiqueur, Caverne Azurée, Caves Jumelles, Chutes Tohjo, Grotte Argentée, Grotte Falaise, Grotte Sombre, Mont Creuset, Mont Sélénite, Puits Ramoloss, Route Victoire, Route de Glace, Tourb'Îles, Îles Écume

The foe is razed with a mystical fire of great intensity. It may also leave the target with a burn.The ability to decorate the player's room, a feature introduced in the original Gold and Silver, is absent.