Solgar Magnesium with Vitamin B6 - Supports Energy Levels - Reduce Tiredness and Fatigue - Muscle Function - Vegan - 100 Tablets

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People who experience migraines may have lower levels of magnesium in their blood and body tissues compared with others. Magnesium levels in a person’s brain may be low during a migraine. While it appears that high doses of vitamin B6 supplements may provide anti-inflammatory benefits for people with rheumatoid arthritis over time, more research is needed. Studies show that people with high blood pressure may see improvements when supplementing this mineral ( 6, 7). Rutjes AW, Denton DA, Di Nisio M, et al. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. Cochrane Database Syst Rev. 2018;12(12):CD011906. Published 2018 Dec 17. doi:10.1002/14651858.CD011906.pub2 There's not enough evidence to show what the effects may be of taking high doses of vitamin B12 supplements each day. What does the Department of Health and Social Care advise?

Lin PT, Cheng CH, Liaw YP, Lee BJ, Lee TW, Huang YC. Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease. 2006;22(11-12):1146-1151. Besag FMC, Vasey MJ, Sen A. Current evidence for adjunct pyridoxine (vitamin B6) for the treatment of behavioral adverse effects associated with levetiracetam: A systematic review. Epilepsy Behav. 2023;140:109065. doi:10.1016/j.yebeh.2022.109065 A review of 3 studies among older adults found that supplementing with 320–720 mg of magnesium daily for up to 8 weeks decreased the time it took them to fall asleep and increased total sleep time compared with placebo ( 10). Biotin is also found in a wide range of foods, but only at very low levels. What happens if I take too much biotin?Schwalfenberg GK, Genuis SJ. The importance of magnesium in clinical healthcare. Scientifica (Cairo). 2017;2017:4179326. doi:10.1155/2017/4179326

But as vitamin B12 is not found naturally in foods such as fruit, vegetables and grains, vegans may not get enough of it. It’s also available as an oil that can be applied topically, but further studies are needed to fully understand how well magnesium in this form is absorbed through the skin ( 11). Magnesium hydroxide People with low magnesium levels are more likely to experience sleep problems, such as difficulties falling or staying asleep, and magnesium supplements have been shown to improve sleep.Fathizadeh N, Ebrahimi E, Valiani M, Tavakoli N, Yar MH. Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iran J Nurs Midwifery Res. 2010;15(Suppl 1):401-405.

A 2015 review in the World Journal of Diabetes reports that most, but not all, people with diabetes have low magnesium and that magnesium may play a role in diabetes management. Researchers suspect that B6 helps with emotional symptoms related to PMS due to its role in creating neurotransmitters that regulate mood.

Sleep: Magnesium plays a vital role in helping bind and stimulate GABA receptors in the brain, which applies the brakes on brain activity and helps support relaxation and sleep 4. These amounts of B6 are significantly higher than the RDA and sometimes combined with other B vitamins. It’s difficult to assess if increasing intake of B6 from dietary sources has the same benefits for certain conditions that supplements may provide. The richest food sources of magnesium include dark chocolate, nuts (cashews, almonds, Brazil nuts), seeds, legumes, bananas and leafy greens (kale, spinach, mustard greens, collared greens and turnip greens). There’s also a decent amount of magnesium in coffee as well! You should be able to get all the chromium you need by eating a varied and balanced diet. What happens if I take too much chromium? Malouf R, Grimley Evans J. The effect of vitamin B6 on cognition. Cochrane Database Syst Rev. 2003;(4):CD004393.

If you eat meat, fish or nuts, you should be able to get all the selenium you need from your daily diet. What happens if I take too much selenium? Artukoglu BB, Li F, Szejko N, Bloch MH. Pharmacologic treatment of tardive dyskinesia: a meta-analysis and systematic review. J Clin Psychiatry. 2020;81(4):19r12798. doi:10.4088/JCP.19r12798 Several studies have linked low blood levels and intakes of vitamin B6 to depression. However, taking vitamin B6 doesn’t appear to prevent or treat this condition ( 35, 36, 37). Summary There's not enough evidence to know what the effects might be of taking high doses of riboflavin supplements each day. What does the Department of Health and Social Care advise?On the other hand, a study in 43 adults with rheumatoid arthritis that took 5 mg of folic acid alone or 100 mg of vitamin B6 with 5 mg of folic acid daily showed that those who received B6 had significantly lower levels of pro-inflammatory molecules after 12 weeks ( 48). Small-scale studies, including a 2012 article, suggest that taking magnesium supplements along with vitamin B-6 can improve PMS symptoms. However, a more recent 2019 review reports that the research is mixed, and further studies are needed. Magnesium hydroxide, or milk of magnesia, works as a laxative by pulling water into your intestines, which helps soften your stool and ease its passage.