Protexin Veterinary Synbiotic D-C Daily probiotic and prebiotic capsules for dogs and cats (Pack of 1, 50 Capsules)

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The most promising applications for probiotics are treatment of acute uncomplicated diarrhea, prevention of stress diarrhea, prevention of antibiotic-associated GI signs, and adjunct therapy for chronic enteropathies ( TABLE 1 ). Probiotics need 1 to 3 days to colonize the intestines. 19 When the goal is prevention of stress-related diarrhea (during periods of weaning, boarding, or traveling or for working dogs), prophylactic administration of a probiotic a few days to weeks ahead of the event may increase success. Similarly, if the goal is prevention of antibiotic-associated GI signs, administering probiotics a few days ahead of a procedure will increase success. Alshawaqfeh, M., Wajid, B., Minamoto, Y., Markel, M., Lidbury, J., Steiner, J., Serpedin, E., Suchodolski, J., 2017. A dysbiosis index to assess microbial changes in fecal samples of dogs with chronic inflammatory enteropathy. FEMS Microbiology Ecology.. doi:10.1093/femsec/fix136 Ministero della Salute y Secretaría de Agricultura, Ganadería y Pesca. Guidelines on Probiotics and Prebiotics [Italian] http://www.salute.gov.it/imgs/C_17_pubblicazioni_1016_ulterioriallegati_ulterioreallegato_0_alleg.pdf (2018).

A systematic review of 384 interventions involving prebiotics, probiotics and synbiotics found that no safety-related data were reported in 37% of the RCTs and 89 studies only used generic statements to describe AEs 76. Up to 98% of studies did not provide a definition of AEs or serious AEs, the number of participant withdrawals due to AEs, or the number of AEs and serious AEs per study group. Taken together, these results are evidence that some studies inadequately collect or report data on AEs. van den Nieuwboer and colleagues 72, 77, 78, 79 reviewed the AEs reported in studies with probiotic and synbiotic interventions and classified them according to the Common Terminology Criteria for Adverse Events system 80; they found that the incidence of AEs in each category was either no different from or often lower in the control groups than in the treatment group.Eslamparast, T. et al. Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: a randomised, double-blind, placebo-controlled pilot study. Br. J. Nutr. 112, 438–445 (2014).

Closa-Monasterolo, R. et al. Safety and efficacy of inulin and oligofructose supplementation in infant formula: results from a randomized clinical trial. Clin. Nutr. 32, 918–927 (2013). Le Bastard, Q. et al. Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications. Aliment. Pharmacol. Ther. 47, 332–345 (2018). Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K. & Knight, R. Diversity, stability and resilience of the human gut microbiota. Nature 489, 220–230 (2012). Hadi, A., Alizadeh, K., Hajianfar, H., Mohammadi, H. & Miraghajani, M. Efficacy of synbiotic supplementation in obesity treatment: a systematic review and meta-analysis of clinical trials. Crit. Rev. Food Sci. Nutr. 60, 584–596 (2020). Islek, A., Sayar, E., Yilmaz, A. & Artan, R. Bifidobacterium lactis B94 plus inulin for Treatment of Helicobacter pylori infection in children: does it increase eradication rate and patient compliance? Acta Gastroenterol. Belg. 78, 282–286 (2015).

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Gerardo, N. & Hurst, G. Q&A: friends (but sometimes foes) within: the complex evolutionary ecology of symbioses between host and microbes. BMC Biol. 15, 126 (2017). Regulatory authorities are primarily focused on two issues: product safety and product labelling. These encompass both truthfulness and compliance with regulatory statutes. Even if the term synbiotic is not included in governmental guidelines or regulations, the use of our proposed scientific definition of the term will aid regulatory oversight of products labelled as ‘synbiotic’. Faculty of Kinesiology and Department of Biochemistry and Mol

Meance, S. et al. Recent advances in the use of functional foods: effects of the commercial fermented milk with Bifidobacterium animalis strain DN-173 010 and yoghurt strains on gut transit time in the elderly. Microb. Ecol. Health Dis. 15, 15–22 (2003). Hadi, A., Mohammadi, H., Miraghajani, M. & Ghaedi, E. Efficacy of synbiotic supplementation in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis of clinical trials: Synbiotic supplementation and NAFLD. Crit. Rev. Food Sci. Nutr. 59, 2494–2505 (2019). Explore Hyperdrug's expertly curated selection of probiotics for dogs to enhance your dog's gut health and digestive wellbeing. Our premium range encompasses veterinarian-recommended probiotics, specifically formulated to foster the growth of beneficial bacteria within your dog's digestive tract. This aids in achieving a harmonious balance of gut flora and includes agents that contribute to healthy stool formation. Ideally, the health benefit of a synbiotic would be superadditive, that is, it would exceed the benefit observed for the sum of the individual components. However, owing to the difficulties in demonstrating different levels of health benefit in an efficacy trial, the panel did not insist upon this aspect. Instead, we advocate requiring a measurable, confirmed health benefit of the synbiotic, which is conferred, at least in part, through selective utilization of the substrate(s) provided in the synbiotic. Although in vitro and animal models are used frequently to test the effects of probiotics, prebiotics and synbiotics 50, 51, 52, 53, it is our position that these have not been fully validated as predictive and that definitive tests of these interventions must be performed in the target host. Of course, model experiments can add mechanistic insights, in particular in cases for which available samples from studies in the target host have limited usefulness (for example, faeces, which are not reflective of upstream intestinal microbial or metabolic activities).Pilla R, Suchodolski JS. The role of the canine gut microbiome and metabolome in health and gastrointestinal disease. Front Vet Sci 2020;6:498.