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Discovery Mindblown Action Circuitry Floating Ball Experiment Set

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Solomon, R. B., Trujillo-Pisanty, I., Conover, K., and Shizgal, P. (2015). Psychophysical inference of frequency-following fidelity in the neural substrate for brain stimulation reward. Behav. Brain Res. 292, 327–341. doi: 10.1016/j.bbr.2015.06.008 Shizgal, P., Schindler, D., and Rompré, P. P. (1989). Forebrain neurons driven by rewarding stimulation of the medial forebrain bundle in the rat: comparison of psychophysical and electrophysiological estimates of refractory periods. Brain Res. 499, 234–248. doi: 10.1016/0006-8993(89)90771-3 Redish, A. D. (2016). Vicarious trial and error. Nat. Rev. Neurosci. 17, 147–159. doi: 10.1038/nrn.2015.30 Dimidjian, S., Barrera, M., Martell, C., Muñoz, R. F., and Lewinsohn, P. M. (2011). The Origins and Current Status of Behavioral Activation Treatments for Depression. Annu. Rev. Clin. Psychol. 7, 1–38. doi: 10.1146/ANNUREV-CLINPSY-032210-104535 Ueda, H. R., Ertürk, A., Chung, K., Gradinaru, V., Chédotal, A., Tomancak, P., et al. (2020). Tissue clearing and its applications in neuroscience. Nat. Rev. Neurosci. 21, 61–79. doi: 10.1038/s41583-019-0250-1

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Betley, J.N., Cao, Z.F.H., Ritola, K.D., and Sternson, S.M. (2013). Parallel, redundant circuit organization for homeostatic control of fe Cooper, J. A., Arulpragasam, A. R., and Treadway, M. T. (2018). Anhedonia in depression: biological mechanisms and computational models. Curr. Opin. Behav. Sci. 22, 128–135. doi: 10.1016/j.cobeha.2018.01.024 Jbabdi, S., Sotiropoulos, S. N., Haber, S. N., Van Essen, D. C., and Behrens, T. E. (2015). Measuring macroscopic brain connections in vivo. Nat. Neurosci. 18, 1546–1555. doi: 10.1038/nn.4134Scangos, K. W., Khambhati, A. N., Daly, P. M., Makhoul, G. S., Sugrue, L. P., Zamanian, H., et al. (2021). Closed-loop neuromodulation in an individual with treatment-resistant depression. Nat. Med. 10, 1696–1700. doi: 10.1038/s41591-021-01480-w The discovery that rodents will work for specific optogenetic stimulation of midbrain dopamine cells seems to fit the series-circuit model nicely. However, application of the reward-mountain method to optical self-stimulation places a seemingly insurmountable obstacle in the path of the series-circuit model.

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