Joined in 2023 
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63 About this deal
TP-110, a new proteasome inhibitor, has previously shown potent growth inhibition in various tumor cell lines. In this study, the mechanism of TP-110-induced apoptosis is investigated in a human multiple myeloma cell line. Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. Although the expression of Bcl-2, Bcl-xL and Bax was not affected by the treatment of TP-110, cleavage of Bid and release of cytochrome c were enhanced. Interestingly, TP-110 reduced the intrinsic inhibitor of apoptosis proteins (IAPs), cIAP-1 and XIAP, that suppress executioner caspases. The reduction of IAPs was observed not only by TP-110, but also by another proteasome inhibitor, MG-132. These results indicate that proteasome inhibitors reduce the level of IAPs and that the apoptosis induced by TP-110 is correlated with the level of IAPs in leukemia cell lines. Additionally, a reduction of cIAP-1 and XIAP by TP-110 contributes to the sensitization of Fas-mediated apoptosis. Taken together, the alteration of the apoptosis regulatory proteins by a proteasome inhibitor induces apoptosis in tumor cells. As much as I find the sounds in the MODX6 good, it's just the most inhumane user interface and sound architecture ever created. Whenever I have to make a split/layer on the spot, I curse Yamaha designers. And I realize it's a board for a studio where you have all the time in the world to program it by dedicating your life to studying it and reading the reference manual that competes with the Bible on text volume, as well as ask on various forums, including the Yamaha one where the log-in function works 1 out of 10 times, which was admitted even by Bad Mister (the guru of Yamaha programming). The Tapo Smart Plug is not appropriate for outdoor use because it is neither waterproof nor dustproof. For Tapo P110/P115, you may use the energy monitor data to determine whether the washing machine is still in use. Can I uninstall the Tapo APP after configuration if I just want to use Alexa APP to control the Tapo Smart Plugs?
How to unbind the account (TP-Link ID) with Tapo&Kasa smart devices in the Tapo app 09-13-2023 78372 If I only want to use the Alexa APP to operate the Tapo Smart Plugs after configuration, can I delete the Tapo APP? Yes, you can share your devices with your families or log into the Tapo APP with the same TP-Link ID to multiple phones. Remote Control –Instantly turn connected devices on/off from wherever you are through the Tapo app.
Schedule
How to configure the Notification feature for the Tapo & Kasa devices on the Tapo app 09-20-2023 7101 How to set up schedule, away mode, and timer for Tapo smart devices (smart plug, smart bulb, smart switch) 09-01-2023 62831 EV charging is not supported since it typically requires higher power, and its charging current exceeds the rated current of the plug How can I change the device name, device icon and location in Tapo app for my smart devices (smart plug, smart camera, smart bulb)? 09-01-2023 59561
What to do if firmware update of my Tapo smart devices (smart plug, smart camera, smart lighting) failed? 07-30-2021 55678 If I get this, it will be for my (well, rare but still existent) jam sessions with some of my friends. Currently I'm using the MODX6 (mostly as a Rhodes/piano board) together with a ASM Hydrasynth (with polyphonic aftertouch!). And as much as I may seem like a very tech-savvy person (or do I?) I'm actually a rather dumb keyboard user who has a lifelong problem with long-term memory and I simply can't learn how to use the MODX6 or any other complex board in live situations. I really love the Nord style with very intuitive interface with physical switches, etc. Which is why I'm thinking of replacing the MODX6 with either an Electro/Piano or CP73/88 or YC/61/73/88 although I'm not an organ guy and won't care about tonewheel stuff but who knows... actually I've occasionally used Hammond patches too.Feature Filter: All User Application Requirement Configuration Guide Troubleshooting Tapo Others Q&A of functional explanation or specification parameters Further Assistance When You Set Up FAQs Note: To use the Tapo Smart Plug with Alexa and Google Home Apps, you have to complete configuration steps for the Tapo Smart Plug via Tapo APP firstly. Making Your Account More Secure: Introducing Two-Step Verification (2FA) for the Tapo App 09-12-2023 38193 How to connect my Tapo device (smart plug, smart camera, smart lighting) to Google Home 07-30-2021 197667 Yes, you can delete the Tapo app and use the Plug with Alexa only after configuring it using the app and associating it with Alexa. You won't be able to use all of the Smart Plug's features, though.
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