Pernaton Green Lipped Mussel Gel for Joint Care, Natural Cooling Gel for Joint Pain, Arthritis, Sciatica, Pain Relief Gel for Joints and Muscles with Original Perna Extract, 125ml

Product Information

The green-lipped mussel ( Perna canaliculus) is a product of marine aquaculture cultivated especially for food in the clear water off the coast of New Zealand. It is named for the bright green stripe visible inside the lip of the shell. Out of 47 people with hip or knee osteoarthritis, those taking green lipped mussel extracts showed significantly greater improvement in joint pain than those taking fish oil, with an 89% decrease in pain symptoms and physical discomfort, with 91% reporting an improved quality of life. These results suggest that green-lipped mussel extracts have an additional mechanism of action to the presence of omega-3 fatty acids. How green-lipped mussel extracts work

Now there’s one more difference between green lipped mussels and NSAIDs … and it has to do with special fats found in the mussels. Fatty Acids Are Important For Your Dog In vivo studies related to these peptides exerting relevant bioactivity should be studied further since they might be susceptible to hydrolytic degradations or modifications by intracellular peptidases [ 38]. The application of bioinformatics provides a promising solution for less time-consuming and more efficient separation of peptides based on their functional characteristics. Therefore, classic methods of isolating bioactive peptides from food proteins combined with an in silico method of identifying them proved to be successful in the production of therapeutic agents (the antioxidant and ACE inhibitors) from green-lipped mussels. The essential omega-3 fatty acids also have anti-inflammatory effects, which helps reduce inflammation and can inhibit inflammation and conditions like osteoarthritis occuring in the first place. Preparations made from green-lipped mussels have proven to be as efficient as NSAIDs at reducing inflammation, but GLM is well tolerated without any of the side effects of NSAIDs, including vomiting, diarrhea, ulcers, and bleeding. While you can eat New Zealand green-lipped mussels as a delicacy, heat may destroy some of their anti-inflammatory benefits. Green lipped mussel extracts therefore contain freeze-dried raw powdered mussel extracts, or lipid extracts in an oil base.The antioxidant activities of GPH-IV*-P2 were measured and were found to have a DPPH activity of 17 ± 0.01% and an ABTS activity of 16 ± 0.002%. The antioxidant activities of other peaks were significantly lower. Antioxidant activities of the eluted protein fractions (GPH-I to GPH-VIII) were measured using DPPH and ABTS radical scavenging assays. Among the eight protein fractions, GPH-IV and GPH-V, exhibited the highest DPPH radical scavenging activities of 74.0 ± 0.1% and 70.0 ± 0.03%, respectively. These two protein fractions were also able to scavenge ABTS radicals stronger than the other protein fractions. GPH-IV and GPH-V showed the highest ABTS radical scavenging activities of 85.0 ± 0.01% and 75.0 ± 0.02% respectively. Most studies suggest that green lipped mussels are effective for general joint inflammation and osteoarthritis. There is not yet enough evidence to suggest that it can assist with other joint conditions such as rheumatoid arthritis. There is not yet enough evidence to suggest how green lipped mussels work as an anti-inflammatory. However, there is an abundance of research for its main active components and their effect on inflammation.

Although GLM use with dogs doesn’t require a prescription, it’s always important to discuss all medications and supplements with your dog’s veterinarian before administering anything to your dog. Safe use has not been established in breeding, pregnant, or lactating dogs. Treatments for Your Dog

Help & Advice

There have been a few reports of people experiencing increased tenderness and warmth around the afflicted joints after taking the extract for a few days. This discomfort usually passes after a couple of weeks, and is often an indication that the product is working on the joints. An analgesic can help provide relief in the interim. There are numerous medications in the pharmaceutical industry which can help treat it. However, the supplement market is now, more than ever, easier to access and rely on. One of the primary solutions for inflammation is omega-3 fatty acids, which is found in fatty fash. NSAIDs can cause health issues because COX enzymes protect the liver and gut lining. Inhibiting these enzymes destroys the stomach lining and harms liver cells. But unlike NSAIDs, green lipped mussels also contain LOX (lipoxygenase) inhibitors. These enzymes protect the stomach lining and liver from harm. The New Zealand Green Lipped Mussel is naturally rich in nutrients and inflammatory compounds which is why it is great for alleviating arthritis symptoms. It includes: It was later determined that the mussels were a rich source of anti-inflammatory omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) ( 2, 3, 4).

Due to the main active compounds found in green lipped mussels, especially the omega-3 content, scientists have been researching the effect on cancer. The research is a phase one study into the efficacy of green lipped mussel extract on breast and prostate cancer patients. As of yet, the research is not conclusive enough to suggest that the extract has a guaranteed effect on cancer however some results showed positive results. Symptoms suggestive of occupational asthma and lung function abnormalities, possibly an immunoglobulin E–mediated allergic reaction, have been reported in workers in green-lipped mussel processing plants. Glass 1998 Toxicology Freeze-dried green-lipped mussel powder and lipid extracts are a popular natural treatment for osteoarthritis and may have anti-inflammatory effects against asthma and rheumatoid arthritis.

Safety of GLMs

Due to its anti-inflammatory properties, green-lipped mussel extract has been claimed to reduce joint inflammation, helping relieve arthritis symptoms. Now you know more about the uses of green lipped mussel, how it works and research studies proving its efficacy, let’s tell you our final thoughts: Conclusion Briefly, 20 μL of 100 mU/mL ACE solution was incubated with 50 μL of the assay buffer containing 5 mM HHL and 10 μL of various concentrations (7.8 nM to 62.5 nM) of a known ACE inhibitor, Captopril (Fluka Chemie AG, Buchs, Switzerland), or the freeze-dried hydrolyzed or unhydrolyzed mussel protein samples (10 mg/mL). The reaction was conducted at 37 °C for 30 min and then stopped by adding 50 μL of 1.0 M aqueous NaOH. An aliquot of 50 μL of 20 mg/mL OPA reagent was reacted with the HL produced for 10 min, and the fluorescence intensity was measured at a 385 nm excitation and a 485 nm emission.