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Improved Medihoney Gel Wound and & Burn Dressing from Derma Sciences, 0.5 oz,

£31.665£63.33Clearance
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While care has been taken to ensure that the information prepared by CADTH in this document is accurate, complete, and up-to-date as at the applicable date the material was first published by CADTH, CADTH does not make any guarantees to that effect. CADTH does not guarantee and is not responsible for the quality, currency, propriety, accuracy, or reasonableness of any statements, information, or conclusions contained in any third-party materials used in preparing this document. The views and opinions of third parties published in this document do not necessarily state or reflect those of CADTH. Second, Manuka honey contains a much higher concentration of methylglyoxal (MGO) than regular honey. MGO is an organic compound known for its antibacterial and antiviral properties. Wounds must be protected from external contaminants throughout the course of healing. Doctors and nurses use powerful antiseptics such as Hibiclens soap to regularly clean wounds for a reason-- any new germ to enter the wound area could lead to a bacterial, viral or fungal infection. Occlusive barriers are a wound-care must, insulating the damaged tissue and keeping pathogens out. Honey's high viscosity makes it a particularly effective occlusive barrier for wounds. As a bonus, as long as the wound isn't leaking considerably, a single dressing may last for several days. Robson, V., Dodd, S and Thomas, S. Standardized antibacterial honey (MediHoney®) with standard therapy in wound care: randomized clinical trial. Journal of Advanced Nursing, 2009: p. 565-575. Jull et al. 15 found that, in one trial, there was no significant difference in healing between honey and saline gauze at 16 weeks or in negative wound swabs at four weeks. 15 In another trial, the mean time to surgical closure was not significantly different between honey and povidone-iodine dressing but it was unclear whether the wounds actually healed. 15 Adverse events were not described well enough to be reported in the SR. 15 The authors of the HTA identified an additional RCT of Manuka-honey dressing versus conventional dressing and found there was no statistically significant difference in the mean duration of healing. 12 There was not enough evidence to comment on honey’s effect on infection in diabetic foot ulcer. 12

Acidic pH promotes healing. Honey has an acidic pH of between 3.2 and 4.5. When applied to wounds, the acidic pH encourages the blood to release oxygen, which is important to wound healing. An acidic pH also reduces the presence of substances called proteases that impair the wound healing process. When it’s time to change the dressing, thoroughly clean the wound with a saline solution. Once you do, repeat the same steps. Dunford et al. ( 61) undertook a four-center feasibility study to determine whether Medihoney™ is an acceptable treatment for patients with leg ulcers in terms of pain relief, odour control and overall patient satisfaction. A total of 40 patients whose leg ulcers had not responded to 12 weeks of compression therapy were recruited. Medihoney dressings were applied on their ulcers for the 12-week study period. All other aspects of their care, including the use of compression bandaging, remained unchanged. Overall, ulcer pain and size decreased significantly and odorous wounds were deodorized promptly. It was difficult to fully assess the quality of the guideline by Rutterman et al. 18 because the publication of the guideline that was identified for inclusion in the CADTH review was only a summary document. The full guideline publication could not be reviewed as it was published only in German. Therefore, the assessment presented here was based only on the summary. The overall objectives and target populations and users were well described. The specific health questions covered by the guidelines were unclear and it was also difficult to tell whether public consultation had been sought. The methods for the literature search were not fully described beyond saying they were “systematic” and the methods for formulating the evidence-based guidelines were not described. External review and updating procedures were not specified. The single recommendation in the guideline regarding medical honey was based on two studies and the quality of evidence and strength of recommendation was not described. 18

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Regulski, M. A novel wound care dressing for chronic leg ulcerations. Podiatry Management, 2008. November/December: p. 235-246.

Due to the dressing’s low pH, some patients may notice a slight transient stinging. If stinging persists and cannot be managed with an analgesic, remove dressing, cleanse area, and discontinue the use of MediHoney dressing. Apply the MEDIHONEY gel or paste directly to the wound. If you’re using a calcium alginate dressing, use sterile scissors to resize it, and then gently apply the dressing to the wound bed. We’ve created an FAQ for those new to wound care and MEDIHONEY. This article answers the following: If you care for a loved one with underlying health problems like diabetes or venous insufficiency, MEDIHONEY can reduce the risk of infections, support the removal of necrotic tissue, and encourage the body’s natural wound healing process. MEDIHONEY looks similar in appearance and texture to traditional store-bought honey, but it’s not a sweetener. Instead, it provides an all-natural way to treat open wounds, preventing gangrene and infection. Often, wounds that have progressed carry a malodorous smell. MEDIHONEY has also been shown to decrease odors that may accompany wounds.

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Honey may contain spores from Clostridium botulinum, which are inactivated. The ready to use product is delivered sterile.

One guideline was identified that was created by Rutterman et al. for the German Society for Wound Healing and Wound treatment in 2013. 18 The group undertook a systematic search of the literature to identify relevant RCTs and assessed these using the GRADE criteria. In cases where there was no relevant published literature to support a recommendation that the guideline group wished to make, the members of the development group reached consensus to produce good clinical practice recommendations. 18 The authors of HTA from Healthcare Improvement Scotland 12 did not create their own recommendations but summarized existing guidelines that were identified regarding the use of honey for the treatment of infected wounds. This document is prepared and intended for use in the context of the Canadian health care system. The use of this document outside of Canada is done so at the user’s own risk. The gel sheet is helpful in treating a wide variety ofmild to moderately exudating wounds. ForDRY woundsthese should be managed withMedihoney Antibacterial Medical Honey.Some patients (5 out of 100) experience pain after the application of medical honey to the wound. In some of them, treatment with medical honey has to be stopped. Few patients with pre-existing atopic diseases show local atopic reactions. No severe systemic atopic reaction due to medical honey has been reported in the literature. Medical honey has to be kept in the wound for 12–24h a day. Thus, it is combined with particular dressings like calcium alginates of hydrofiber dressings, which add substantially to the overall cost of treatment. Depending on the amount of exudate, the dressing with medical honey has to be changed up to 2 times a day in acute inflammatory wounds. The most often practised change interval for medical honey dressings is every 24–48h. If you have any questions about applying honey to your wound, follow up with a physician. Types of honey used on wounds Unlike regular honey, MediHoney is controlled against a rigorous set of systems and standards, including independent monitoring and auditing, to guarantee quality and batch-to-batch consistency. It is also ultra-filtrated and sterilized by gamma irradiation, removing any bacterial spores without loss of product effectiveness. 3 MediHoney comes from a traceable source and is free of pesticides and antibiotics. 3 The health benefits, side effects, and risks have been considered in formulating the recommendations. MEDIHONEY wound and burn dressing gel contains a formula of 80% Active Leptospermum Honey (Manuka honey) and 20% natural gelling agents. It’s recommended for the treatment of non-draining to moderately draining wounds, including:

When honey is diluted with water, reducing its high sugar content, it still inhibits the growth of many different bacterial species that cause wound infections ( 14, 15, 17–20). MediHoney dressings aids and supports autolytic debridement and a moist wound healing environment in acute and chronic wounds and burns, 5-8 through two key mechanisms – high osmolarity and low pH. The high sugar content of honey facilitates movement of fluid from an area of higher concentration, across a membrane, to an area of lower concentration. Osmotic potential draws fluid through the wound, to the surface, helping to liquefy non-viable tissue. Lusby PE, Coombes A, Wilkinson JM. Honey. A potent agent for wound healing? J Wound Ostomy Continence Nurs. 2002;29(6):295–300.Although the mechanism(s) by which honey speeds up the healing process have not been determined, there are some findings, which provide possible explanations. One way in which honey may work is through its stimulation of an inflammatory response in leukocytes ( 28, 29, 33), as inflammation is what triggers the cascade of cellular events that give rise to the production of growth factors which control angiogenesis and proliferation of fibroblasts and epithelial cells. Very recently, Tonks et al. discovered a 5.8kDA component of manuka honey which stimulates the production of TNF-α in macrophages via Toll-like receptor 4 ( 34). Antibacterial effect. Honey has been shown to have an antibacterial effect on bacteria commonly present in wounds, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). Part of this resistance may be through its osmotic effects. Sugar has an osmotic effect. The sugar naturally present in honey has the effect of drawing water out of damaged tissues (known as an osmotic effect). This reduces swelling and encourages the flow of lymph to heal the wound. Sugar also draws water out of bacterial cells, which can help keep them from multiplying. In one randomized controlled trial, the mean healing time of wounds treated with MediHoney dressings was significantly faster than the mean healing time of wounds treated with conventional dressings. 4

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