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International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer, Shanghai Key Laboratory of Hepato-biliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China Swamy, M., Jamora, C., Havran, W. & Hayday, A. Epithelial decision makers: in search of the ‘epimmunome’. Nat. Immunol. 11, 656–665 (2010). The procedures of RNA extraction and qPCR were performed as previously described. Primers used for qRT-PCR are listed in Supplementary Table S14. Expression levels were calculated using the 2 −ΔΔCT method with β-actin as the control. Invasion and migration assaysMuthuswamy, S. K. Self-organization in cancer: Implications for histopathology, cancer cell biology, and metastasis. Cancer Cell 39, 443–446 (2021). Chen LT, Liu YG. 2014. Male sterility and fertility restoration in crops. Annual Review of Plant Biology. 65: 579-606.

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