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Akkermansia Muciniphila Probiotic Granules * Live Long * Weight Control Dogadan Bizim (5)

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Liu, R. et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat. Med. 23, 859–868 (2017).

Collado, M.C.; Derrien, M.; Isolauri, E.; de Vos, W.M.; Salminen, S. Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly. Appl. Environ. Microbiol. 2007, 73, 7767–7770. [ Google Scholar] [ CrossRef] [ PubMed]

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Vaishnava, S. et al. The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Sci. (N. Y.) 334, 255–258 (2011). The first human clinical trial with Akkermansia muciniphila was published in the online edition of Nature Medicine on July 1, 2019. Thirty-two subjects with pre-diabetes and evidence of metabolic syndrome (abdominal obesity, elevated blood lipids, high blood pressure, etc.) were randomized to get either a placebo or live or heat-killed (pasteurized) A. muciniphila . The active treatment groups taking A. muciniphila took around 10 billion bacteria (either dead or alive) daily for three months. Koistinen, V. M. et al. Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation. Microbiome 7, 103 (2019). Depommier, C. et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat. Med. 25, 1096–1103 (2019).

Plovier, H. et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat. Med. 23, 107–113 (2017). The new supplement aims to help people with weight management, as well as prevent cardiovascular disease and type II diabetes. Zhang, T. et al. Alterations of Akkermansia muciniphila in the inflammatory bowel disease patients with washed microbiota transplantation. Appl. Microbiol. Biotechnol. 104, 10203–10215 (2020). Kirmiz, N. et al. Comparative Genomics Guides Elucidation of Vitamin B12 Biosynthesis in Novel Human-Associated Akkermansia Strains. Appl. Environ. Microbiol. 86, e02117–e02119 (2020). These bacterial preparations are known as "ghost probiotics," "postbiotics," "inactivated probiotics," and now "para probiotics." The benefits of some products have nothing to do with the organism being alive but instead are due to unique cellular components of the bacteria that are there, whether the bacteria is alive or dead. 8 That is the case with A. muciniphila.Argüello, H. et al. Early Salmonella Typhimurium infection in pigs disrupts Microbiome composition and functionality principally at the ileum mucosa. Sci. Rep. 8, 7788 (2018). Gloor, G. B. & Reid, G. Compositional analysis: a valid approach to analyze microbiome high-throughput sequencing data. Can. J. Microbiol. 62, 692–703 (2016). Research on the intestinal microbiome is uncovering potential new probiotic species that could revolutionize medicine. The gut microbiome is a complex and diverse system composed of genetic material from trillions of microorganisms (microbiota). Without question, the microbiome is a huge contributor to our health and wellness. Zhang, T.; Ji, X.; Lu, G.; Zhang, F. The potential of Akkermansia muciniphila in inflammatory bowel disease. Appl. Microbiol. Biotechnol. 2021, 105, 5785–5794. [ Google Scholar] [ CrossRef] Derrien, M.; Vaughan, E.E.; Plugge, C.M.; de Vos, W.M. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int. J. Syst. Evol. Microbiol. 2004, 54, 1469–1476. [ Google Scholar] [ CrossRef] [ PubMed]

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