Bee Health Propolis Lozenges 114 g Pack of 2

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The antitumor activity of propolis was reviewed by Orsolic et al. The chemopreventive activity of propolis in animal models and cell cultures is likely to be the result of their ability to inhibit DNA synthesis in tumour cells, their capability to induce apoptosis of tumour cells, and their property to activate macrophages to produce factors capable of regulating the function of B, T and NK cells, respectively. Moreover, these results suggest that flavonoids from propolis play a protective role against the toxicity of the chemotherapeutic agents or radiation in mice, giving hope that they may have similar protective action in humans. The combination with an adjuvant antioxidant therapy may enhance the effectiveness of chemotherapy by ameliorating the side effect on leukocytes, liver, and kidneys and consequently enabling dose escalation [ 63]. Although many polyphenols have an antimetastatic activity, caffeic acid phenethyl esters (CAPE) from poplar propolis and Artepillin C from Baccharis propolis have been identified as the most potent antitumor agents [ 64– 68].

Antioxidants have been shown to be capable of scavenging free radicals and thereby protecting lipids and other compounds such as vitamin C from being oxidized or destroyed [ 58]. It is probable that active free radicals, together with other factors, are responsible for cellular aging and degradation in such conditions as cardiovascular diseases, arthritis, cancer, diabetes, Parkinson's disease, and Alzheimer's disease. Oxidative damage may also result in poor liver function. Studies on rats in vitro show that propolis extracts protect against damage to liver cells [ 59]. When applied to the skin: Propolis is possibly safe when used appropriately. It can cause allergic reactions, especially in people who are allergic to other bee products. Pregnancy: There isn't enough reliable information to know if propolis is safe to use when pregnant. Stay on the safe side and avoid use. Pahlavani N, Malekahmadi M, Sedaghat A, et al. Effects of melatonin and propolis supplementation on inflammation, oxidative stress, and clinical outcomes in patients with primary pneumosepsis: a randomized controlled clinical trial. Complement Med Res 2022. View abstract. Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical trial. Phytother Res 2021;35(3):1669-79. View abstract. da Rosa C, Bueno IL, Quaresma ACM, Longato GB. Healing potential of propolis in skin wounds evidenced by clinical studies. Pharmaceuticals. 2022;15(9):1143. doi:10.3390/ph15091143Kubat M, Karabulut Z, Sengül S. Effect of propolis on wound healing in sacrococcygeal pilonidal disease: a randomized controlled clinical trial. Pak J Pharm Sci 2021;34(3(Supplementary)):1063-7. View abstract. United States. National Library of Medicine. National Center for Biotechnology Information. Advances in Pharmacological Sciences. Dec. 9, 2013. "Propolis: A Wonder Bees Product and Its Pharmacological Potentials." It offers an array of benefits for many ailments and is one of nature’s richest sources of bioflavonoids for immune support. Guler E, Bilir O, Osman Kocak A, Atas I, Tanugur Samanci AE. The prophylactic efficacy of Anatolian propolis in individuals at high risk of COVID-19. Eur Rev Med Pharmacol Sci. 2022;26(2 Suppl):53-60. View abstract.

Propolis is a natural adhesive and resin-like substance produced and used by bees to construct and repair their hives. Honeybees produce propolis by collecting pollen, resin, and other substances from various plants such as poplar and coniferous trees and mixing it with beeswax and salivary enzymes they secrete. Propolis is a complex mixture of several chemicals and has been used as traditional medicine since ancient times to treat several ailments. Khalil, M. L. Biological activity of bee propolis in health and disease. Asian Pac.J Cancer Prev. 2006;7(1):22-31. View abstract. Botushanov, P. I., Grigorov, G. I., and Aleksandrov, G. A. A clinical study of a silicate toothpaste with extract from propolis. Folia Med (Plovdiv.) 2001;43(1-2):28-30. View abstract. Propolis is a natural substance collected by honey bees from buds and trees containing tree resin, essential oils, waxes and bioflavonoids.Bosio, K., Avanzini, C., D'Avolio, A., and et al. In vitro activity of propolis against Streptococcus pyogenes. Lett Appl.Microbiol. 2000;31(2):174-177. View abstract.

Conte FL, Tasca KI, Santiago KB, et al. Propolis increases Foxp3 expression and lymphocyte proliferation in HIV-infected people: a randomized, double blind, parallel-group and placebo-controlled study. Biomed Pharmacother 2021;142:111984. View abstract.Trials show that propolis supplements may significantly reduce fasting blood glucose levels, which are a significant indicator of uncontrolled diabetes. While more research needs to be done on this subject, early results are promising. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol. 1990;70:584–6. PubMed Russo, A., Cardile, V., Sanchez, F., Troncoso, N., Vanella, A., and Garbarino, J. A. Chilean propolis: antioxidant activity and antiproliferative action in human tumor cell lines. Life Sci. 12-17-2004;76(5):545-558. View abstract. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). View abstract.

Braakhuis A. Evidence on the health benefits of supplemental propolis. Nutrients. 2019;11(11):2705. doi: 10.3390/nu11112705

Procedures & Tests

Hoheisel O. The effects of Herstat (3% propolis ointment ACF ) application in cold sores: a double-blind placebo-controlled clinical trial. Journal of Clinical Research 2001;4:65-75. Soleimani D, Miryan M, Hadi V, et al. Effect of propolis supplementation on athletic performance, body composition, inflammation, and oxidative stress following intense exercise: a triple-blind randomized clinical trial. Food Sci Nutr 2021;9(7):3631-40. View abstract. Duarte S, Koo H, Bowen WH, et al. Effect of a novel type of propolis and its chemical fractions on glucosyltransferases and on growth and adherence of mutans streptococci. Biol Pharm Bull. 2003;26(4):527-531. doi:10.1248/bpb.26.527 Jalali M, Ranjbar T, Mosallanezhad Z, et al. Effect of propolis intake on serum C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-a) levels in adults: a systematic review and meta-analysis of clinical trials. Complement Ther Med 2020;50:102380. View abstract.