Ultra Pro 3" X 4" Super Thick 130 pt Toploader with Thick Card Sleeves (50 ct.)

Product Information

Tsuji Y. Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle. Cardiovasc Res. 2000; 48(2):S. 300–S. 309. [ PubMed] [ Google Scholar] Bers DM, Lederer WJ (2008) Excitation-contraction coupling and cardiac contractile force, 2nd edn. Springer, Dordrecht Potassium channels are the most important ion channels contributing to repolarization in cardiomyocytes. A consistent feature of cardiomyocytes from patients or animals with HF is prolonged action potential duration (Nuss et al. 1999; Akar and Rosenbaum 2003; Janse 2004), and it becomes obvious that K + channel remodeling is of great importance for repolarization abnormalities. Some of these changes in HF mimic inherited channelopathies that cause long QT syndrome. The interplay between the various K + channel subtypes during the progression to HF is dynamic. The underlying transcriptional, posttranscriptional, and posttranslational remodeling of the individual K + channel types changes their activity and their significance respectively, and they must be viewed together to understand their role in maintaining a stable heart rhythm.

Countries: It is used in following countries: Belize, Canada, Costa Rica, Guatemala, Honduras, Mexico, Nicaragua, El Salvador, United States.

Acronyms

Pogwizd SM, Bers DM. Calcium cycling in heart failure. The arrhythmia connection. J Cardiovasc Electrophysiol. 2002; 13(1):S. 88–S. 91. [ PubMed] [ Google Scholar]

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