Joined in 2023 
82 
63 About this deal
The biggest side effect was increased sleep by about 1-2 hours. But this only happens when I take one specific supplement so switching to another one seemed to fix this. Whilst the ultimate low-cost alternative to high end sulforaphane supplements is sprouting your own (see below), often this can be inconvenient. It takes time, preparation, and isn’t always possible when traveling or busy with work. There are lots of sulforaphane supplements out there. However, some try to save money by using inactive sulforaphane precursors like glucoraphanin. Unless that’s activated by the enzyme myrosinase, it’s pretty useless. Can Activation of NRF2 Be a Strategy against COVID-19?” published in Trends in Pharmacological Sciences One of the primary ways that sulforaphane impacts detoxification is by activating Nrf2. Nrf2 is short for nuclear factor erythroid 2-related factor 2. I don’t know who was involved in naming these compounds, but thankfully, we have the acronym Nrf2. It’s a protein that regulates the expression of both antioxidant- and detoxification-related genes, and it’s been described by scientists as the master redox switch, and the guardian of healthspan and gatekeeper of longevity. Nrf2 controls the expression of over 200 genes involved in the antioxidant response. And research over the past two decades has shown it to be a key modulator of the cell’s primary defense mechanisms. It’s responsible for countering the effects of many harmful environmental toxins and carcinogens. Nrf2 is also responsible for sulforaphane’s activation of the phase two detoxification system, and unlike vitamin C, which has antioxidant effects that last for about one to two hours, sulforaphane’s effects last for up to 72 hours.
Recently, with immune function in mind, Rhonda’s been encouraged by a randomized double-blinded study that found sulforaphane from broccoli sprouts increased the body’s immune function against the influenza virus 1 Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study– Müller et al. (2016). Specifically, it increased Natural Killer cells production of an enzyme that may enhance antiviral defense responses.
Results and Discussion
Specifically, ingested sulforaphane activates what’s called the NRF2 pathway, which increases expression of a battery of cell protective genes, that regulate things like:
Steaming vegetables for one to three minutes may be the best way to optimize sulforaphane levels when cooking ( 3). It’s on the pricier side. But this is a top-tier sulforaphane supplement. Plus, you can save by going for the subscription option. Sulforaphane has been shown to have anticancer properties in a number of test-tube and animal studies, reducing both the size and number of various types of cancer cells ( 5, 6, 7). Number three is sulforaphane’s ability to protect the brain and improve cognitive function. Sulforaphane has been shown to increase brain-derived neurotrophic factor (BDNF) in mice. You’ve probably heard of BDNF by now. It supports the survival of existing neurons and encourages the formation of new neurons and synapses. And low levels of BDNF have been observed in many different conditions, such as autism, Alzheimer’s disease, Parkinson’s disease, anxiety, and brain trauma. Low BDNF has also been linked to accelerated aging, poor neural development, neurotransmitter dysfunction, obesity, depression, and even schizophrenia. Things like intense exercise, sun exposure, and avoiding processed and refined foods have all been shown to increase BDNF, but sulforaphane can have a particularly potent effect here. The closest way I can describe it is how I felt on antidepressants (only took them for a month), but without the dull "I'm a walking corpse" feeling. Sulforaphane reduces the overstimulation/hyperactivity of my brain.We also looked for products with the myrosinase enzyme needed to convert glucoraphanin to sulforaphane in the small intestine. Potency Each bottle contains 60 capsules. The serving size is 2 capsules, so it will last one month. Each serving gives you 20 mg of active sulforaphane. This studyon diabetic patients found that 100 grams of sulforaphane-rich broccoli sprouts daily reduced markers of oxidative stress and LDL cholesterol and increased HDL cholesterol levels. There’s some concern that sulforaphane may disrupt thyroid health. This is mainly because cruciferous vegetables (like broccoli and cauliflower) contain compounds called goitrogens that may interfere with thyroid function if eaten in excessive amounts. Make sure you take the equivalent of 15-25 mg (or 9-27 mg if you want to go by the research). I had zero noticable effects from taking 5-10 mg (usually one capsule). When I upped my dose, I noticed effects within 3 days.
Mild side effects have been associated with sulforaphane supplements, such as an increase in gas, constipation, and diarrhea ( 17, 29). Another factor to consider is the dosage. The optimal dosage of sulforaphane supplements is not yet clear, but studies have used doses ranging from 10 to 100 milligrams per day. It’s also essential to choose a supplement that is free from additives and fillers.Keep in mind that these studies use a concentrated form of sulforaphane, so it’s unclear whether the amounts found in fresh foods have the same effect. Let’’ move on to supplements. As I mentioned earlier, the problem here is that the vast majority of supplements on the market don’t have any sulforaphane in them at all. They contain sulforaphane precursors, like sulforaphane glucosinolate, which requires the enzyme myrosinase to be converted into sulforaphane. While some people do have gut flora that produce myrosinase, others don’t. And even when they do, the conversion is really inefficient. As we talked about, it ranges from 1 to 40 percent, but the average is only 5 to 10 percent. And that’s not enough to induce Nrf2, which is the primary mechanism for sulforaphane’s benefits. Now, some companies put myrosinase into the supplement capsule, along with the sulforaphane precursors. And these products will say something like “with myrosinase” on the label. The idea is that by putting myrosinase in the capsule, it will convert the precursors into active sulforaphane. But this doesn’t appear to work very well. Two clinical trials that used the supplement with myrosinase in the capsule failed to show benefits despite sulforaphane’s well-established effects for the conditions that were being studied. Both test-tube and animal studies show that sulforaphane may boost heart health in a number of ways ( 13).
Great Deal 
New Comment