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Other methods of preparation (besides smoking), include processing into regular opium tincture ( tinctura opii), laudanum, paregoric ( tinctura opii camphorata), herbal wine (e.g., vinum opii), opium powder ( pulvis opii), opium sirup ( sirupus opii) and opium extract ( extractum opii). [123] Vinum opii is made by combining sugar, white wine, cinnamon, and cloves. Opium syrup is made by combining 97.5 part sugar syrup with 2.5 parts opium extract. Opium extract ( extractum opii) finally can be made by macerating raw opium with water. To make opium extract, 20 parts water are combined with 1 part raw opium which has been boiled for 5 minutes (the latter to ease mixing). [123] Some competition came from the newly independent United States, which began to compete in Guangzhou, selling Turkish opium in the 1820s. Portuguese traders also brought opium from the independent Malwa states of western India, although by 1820, the British were able to restrict this trade by charging "pass duty" on the opium when it was forced to pass through Bombay to reach an entrepot. [20] Anil Aggrawal (1995). "CHAPTER 2: THE STORY OF OPIUM". Narcotic Drugs. New Delhi: National Book Trust. ISBN 978-81-237-1383-0. Opium poppies are popular and attractive garden plants, whose flowers vary greatly in color, size and form. A modest amount of domestic cultivation in private gardens is not usually subject to legal controls. In part, this tolerance reflects variation in addictive potency. A cultivar for opium production, Papaver somniferum L. elite, contains 91.2 percent morphine, codeine, and thebaine in its latex alkaloids, whereas in the latex of the condiment cultivar "Marianne", these three alkaloids total only 14.0 percent. The remaining alkaloids in the latter cultivar are primarily narcotoline and noscapine. [115] Ouchterlony, John (1844). The Chinese war: an account of all the operations of the British forces from the commencement to the Treaty of Nanking. London: Saunders and Otley.
Prescriptions must be written on an Authority Prescription Form, and the approval number must be noted on the prescription. Pharmacists cannot dispense the item as a pharmaceutical benefit unless it has been approved by Medicare Australia (indicated by the presence of the approval number). Darke S, Zador D (December 1996). "Fatal heroin 'overdose': a review". Addiction. 91 (12): 1765–72. doi: 10.1046/j.1360-0443.1996.911217652.x. PMID 8997759. The production methods have not significantly changed since ancient times. Through selective breeding of the Papaver somniferum plant, the content of the phenanthrene alkaloids morphine, codeine, and to a lesser extent thebaine has been greatly increased. In modern times, much of the thebaine, which often serves as the raw material for the synthesis for oxycodone, hydrocodone, hydromorphone, and other semisynthetic opiates, originates from extracting Papaver orientale or Papaver bracteatum. Ahmad, Diana L. The Opium Debate and Chinese Exclusion Laws in the Nineteenth-century American West (University of Nevada Press, 2007). Drugs and Racism in the Old West.One reason for the increase in opiate consumption in the United States during the 19th century was the prescribing and dispensing of legal opiates by physicians and pharmacists to women with "female complaints" (mostly to relieve menstrual pain and hysteria). [34] Because opiates were viewed as more humane than punishment or restraint, they were often used to treat the mentally ill. Between 150,000 and 200,000 opiate addicts lived in the United States in the late 19th century and between two-thirds and three-quarters of these addicts were women. [37]
Smoking of opium declined in the 20th century, partly because it had been supplanted by more-potent derivatives and partly because of determined efforts in China and other developing countries to eradicate it. In the late 1990s, drug-control programs headed by the United Nations and by individual governments contributed to a reduction in opium poppy cultivation in the Golden Triangle. However, the region subsequently became a major producer of other illicit substances, including methamphetamines. Simon O'Dochartaigh. "HON Mother & Child Glossary, Meconium". hon.ch. Archived from the original on May 1, 2021 . Retrieved April 4, 2016. Poppy seeds are a common and flavorsome topping for breads and cakes. One gram of poppy seeds contains up to 33 micrograms of morphine and 14 micrograms of codeine, and the Substance Abuse and Mental Health Services Administration in the United States formerly mandated that all drug screening laboratories use a standard cutoff of 300 nanograms per milliliter in urine samples. A single poppy seed roll (0.76grams of seeds) usually did not produce a positive drug test, but a positive result was observed from eating two rolls. A slice of poppy seed cake containing nearly five grams of seeds per slice produced positive results for 24 hours. Such results are viewed as false positive indications of drug use and were the basis of a legal defense. [117] [118] On November 30, 1998, the standard cutoff was increased to 2000 nanograms (two micrograms) per milliliter. [119] Confirmation by gas chromatography-mass spectrometry will distinguish amongst opium and variants including poppy seeds, heroin, and morphine and codeine pharmaceuticals by measuring the morphine:codeine ratio and looking for the presence of noscapine and acetylcodeine, the latter of which is only found in illicitly produced heroin, and heroin metabolites such as 6-monoacetylmorphine. [120] Harvesting and processing [ edit ] Harvesting opium Karl A. Sporer, M.D. (April 6, 1999). "Acute Heroin Overdose". Annals of Internal Medicine. 130 (7): 584–590. doi: 10.7326/0003-4819-130-7-199904060-00019. PMID 10189329. S2CID 22949289. Senlis Council (September 26, 2005). "The Kabul International Symposium on Drug Policy". Archived from the original on March 13, 2007 . Retrieved May 4, 2007.Despite drastic penalties and continued prohibition of opium until 1860, opium smuggling rose steadily from 200 chests per year under the Yongzheng Emperor to 1,000 under the Qianlong Emperor, 4,000 under the Jiaqing Emperor, and 30,000 under the Daoguang Emperor. [61] The illegal sale of opium became one of the world's most valuable single commodity trades and has been called "the most long continued and systematic international crime of modern times". [62] Opium smuggling provided 15 to 20 percent of the British Empire's revenue and simultaneously caused scarcity of silver in China. [63] a b P. G. Kritikos & S. P. Papadaki (January 1, 1967). "The early history of the poppy and opium". Journal of the Archaeological Society of Athens. a b Kramer John C (1979). "Opium Rampant: Medical Use, Misuse and Abuse in Britain and the West in the 17th and 18th Centuries". British Journal of Addiction. 74 (4): 377–389. doi: 10.1111/j.1360-0443.1979.tb01367.x. PMID 396938.
William Travis Hanes; Frank Sanello (2004). Opium Wars: The Addiction of One Empire and the Corruption of Another. Sourcebooks, Inc. pp.78–. ISBN 978-1-4022-0149-3. Max Chamka; Translated by Geraldine Ring. "3 grams of opium for 1 dollar". Caucaz europenews . Retrieved May 6, 2007.Habighorst, Ludwig V., Reichart, Peter A., Sharma, Vijay, Love for Pleasure: Betel, Tobacco, Wine and Drugs in Indian Miniatures (Koblenz: Ragaputra Edition, 2007) Morewood, Samuel (1838). A philosophical and statistical history of the inventions and customs of ancient and modern nations in the manufacture and use of inebriating liquors; with the present practice of distillation in all its varieties: together with an extensive illustration of the consumption and effects of opium, and other stimulants used in the East, as substitutes for wine and spirits. Dublin, W. Curry and W. Carson. Professor Arthur C. Gibson. "The Pernicious Opium Poppy". University of California, Los Angeles. Archived from the original on October 20, 2013 . Retrieved February 22, 2014. a b Aurin, Marcus (January 1, 2000). "Chasing the Dragon: The Cultural Metamorphosis of Opium in the United States, 1825–1935". Medical Anthropology Quarterly. 14 (3): 414–441. doi: 10.1525/maq.2000.14.3.414. JSTOR 649506. PMID 11036586.
Smoking of opium came on the heels of tobacco smoking and may have been encouraged by a brief ban on the smoking of tobacco by the Ming emperor. The prohibition ended in 1644 with the coming of the Qing dynasty, which encouraged smokers to mix in increasing amounts of opium. [1] In 1705, Wang Shizhen wrote, "nowadays, from nobility and gentlemen down to slaves and women, all are addicted to tobacco." Tobacco in that time was frequently mixed with other herbs (this continues with clove cigarettes to the modern day), and opium was one component in the mixture. Tobacco mixed with opium was called madak (or madat) and became popular throughout China and its seafaring trade partners (such as Taiwan, Java, and the Philippines) in the 17th century. [47] In 1712, Engelbert Kaempfer described addiction to madak: "No commodity throughout the Indies is retailed with greater profit by the Batavians than opium, which [its] users cannot do without, nor can they come by it except it be brought by the ships of the Batavians from Bengal and Coromandel." [20] Benjamin Pui-Nin Mo & E. Leong Way (October 1, 1966). "An Assessment Of Inhalation As A Mode Of Administration Of Heroin By Addicts". Journal of Pharmacology and Experimental Therapeutics. 154 (1): 142–151. PMID 5924312 . Retrieved June 6, 2007. Opium contains two main groups of alkaloids. Phenanthrenes such as morphine, codeine, and thebaine are the main psychoactive constituents. [153] Isoquinolines such as papaverine and noscapine have no significant central nervous system effects. Morphine is the most prevalent and important alkaloid in opium, consisting of 10–16 percent of the total, and is responsible for most of its harmful effects such as lung edema, respiratory difficulties, coma, or cardiac or respiratory collapse. Morphine binds to and activates mu opioid receptors in the brain, spinal cord, stomach and intestine. Regular use can lead to drug tolerance or physical dependence. Chronic opium addicts in 1906 China [48] consumed an average of eight grams of opium daily; opium addicts in modern Iran [154] are thought to consume about the same. For light intensity: spray in a cloud around your head and shoulders, let the fragrance fall gently around you.Use of opium as a cure-all was reflected in the formulation of mithridatium described in the 1728 Chambers Cyclopedia, which included true opium in the mixture. Merlin, M. D. (September 2003). "Archaeological Evidence for the Tradition of Psychoactive Plant Use in the Old World". Economic Botany. 57 (3): 295–323. doi: 10.1663/0013-0001(2003)057[0295:aeftto]2.0.co;2. ISSN 0013-0001. JSTOR 4256701. S2CID 30297486 . Retrieved May 31, 2022. Inglis, Lucy, Milk of Paradise: A History of Opium, Pan Macmillan, London, 2018. **Review: Julie Peakman: "Not Just Smelling the Flowers", History Today History Today Vol. 68/10, October 2018, pp.102–103. Albert D. Fraser & David Worth (October 1999). "Experience with a Urine Opiate Screening and Confirmation Cutoff of 2000 mg/ml". Journal of Analytical Toxicology. 23 (6): 549–551. doi: 10.1093/jat/23.6.549. PMID 10517566. This section needs additional citations for verification. Please help improve this article by adding citations to reliable sourcesin this section. Unsourced material may be challenged and removed. ( February 2021) ( Learn how and when to remove this template message)
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