Black Opium Nuit Blanche by Yves Saint Laurent Eau De Parfum For Women 90ml

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Presley CC, Lindsley CW. DARK Classics in Chemical Neuroscience: opium, a historical perspective. ACS Chemical Neuroscience. 2018;9(10):2503-18.

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Speer, William (1870). The oldest and the newest empire: China and the United States. Hartford, Conn., S. S. Scranton and company; Philadelphia, Parmelee & co.; [etc., etc.] E. Guerra Doce (January 1, 2006). "Evidencias del consumo de drogas en Europa durante la Prehistoria". Trastornos Adictivos (in Spanish). 8 (1): 53–61. doi: 10.1016/S1575-0973(06)75106-6. Archived from the original on May 15, 2008 . Retrieved May 10, 2007. (includes image) Heroin, the first semi-synthetic opioid, was first synthesized in 1874, but was not pursued until its rediscovery in 1897 by Felix Hoffmann at the Bayer pharmaceutical company in Elberfeld, Germany. From 1898 to 1910 heroin was marketed as a non-addictive morphine substitute and cough medicine for children. Because the lethal dose of heroin was viewed as a hundred times greater than its effective dose, heroin was advertised as a safer alternative to other opioids. [104] By 1902, sales made up 5 percent of the company's profits, and "heroinism" had attracted media attention. [105] Oxycodone, a thebaine derivative similar to codeine, was introduced by Bayer in 1916 and promoted as a less-addictive analgesic. Preparations of the drug such as oxycodone with paracetamol and extended release oxycodone remain popular to this day. [ citation needed] Ahmad, Diana L. The Opium Debate and Chinese Exclusion Laws in the Nineteenth-century American West (University of Nevada Press, 2007). Drugs and Racism in the Old West.a b Kramer John C (1979). "Opium Rampant: Medical Use, Misuse and Abuse in Britain and the West in the 17th and 18th Centuries". British Journal of Addiction. 74 (4): 377–389. doi: 10.1111/j.1360-0443.1979.tb01367.x. PMID 396938. Max Chamka; Translated by Geraldine Ring. "3 grams of opium for 1 dollar". Caucaz europenews . Retrieved May 6, 2007. Martin, Steven. The Art of Opium Antiques. Chiang Mai: Silkworm Books, 2007. Photographs and history of Chinese and Vietnamese opium-smoking paraphernalia.

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Latimer, Dean, and Jeff Goldberg with an Introduction by William Burroughs. Flowers in the Blood: The Story of Opium. New York: Franklin Watts, 1981Inglis, Lucy, Milk of Paradise: A History of Opium, Pan Macmillan, London, 2018. **Review: Julie Peakman: "Not Just Smelling the Flowers", History Today History Today Vol. 68/10, October 2018, pp.102–103. Albert D. Fraser & David Worth (October 1999). "Experience with a Urine Opiate Screening and Confirmation Cutoff of 2000 mg/ml". Journal of Analytical Toxicology. 23 (6): 549–551. doi: 10.1093/jat/23.6.549. PMID 10517566. Opium contains two main groups of alkaloids. Phenanthrenes such as morphine, codeine, and thebaine are the main psychoactive constituents. [150] Isoquinolines such as papaverine and noscapine have no significant central nervous system effects. Morphine is the most prevalent and important alkaloid in opium, consisting of 10–16 percent of the total, and is responsible for most of its harmful effects such as lung edema, respiratory difficulties, coma, or cardiac or respiratory collapse. Morphine binds to and activates mu opioid receptors in the brain, spinal cord, stomach and intestine. Regular use can lead to drug tolerance or physical dependence. Chronic opium addicts in 1906 China [48] consumed an average of eight grams of opium daily; opium addicts in modern Iran [151] are thought to consume about the same.

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Production of thebaine and oripavine". April 20, 2004. Archived from the original on September 5, 2012 . Retrieved May 10, 2007. William Travis Hanes; Frank Sanello (2004). Opium Wars: The Addiction of One Empire and the Corruption of Another. Sourcebooks, Inc. pp.78–. ISBN 978-1-4022-0149-3. Professor Arthur C. Gibson. "The Pernicious Opium Poppy". University of California, Los Angeles. Archived from the original on October 20, 2013 . Retrieved February 22, 2014. Zhang, Sarah (January 9, 2019). "Why a Medieval Woman Had Lapis Lazuli Hidden in Her Teeth". The Atlantic . Retrieved May 10, 2020.

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Map showing the amount of opium produced in China in 1908: The quote "We English, by the policy we have pursued, are morally responsible for every acre of land in China which is withdrawn from the cultivation of grain and devoted to that of the poppy; so that the fact of the growth of the drug in China ought only to increase our sense of responsibility." is by Lord Justice Fry. Extensive textual and pictorial sources also show that poppy cultivation and opium consumption were widespread in Safavid Iran [42] and Mughal India. [43] England [ edit ]

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John K. Fairbanks, "The Creation of the Treaty System' in John K. Fairbanks, ed. The Cambridge History of China, vol. 10 Part 1 (Cambridge University Press, 1992) p. 213. cited in John Newsinger (October 1997). "Britain's opium wars – fact and myth about the opium trade in the East". Monthly Review. Archived from the original on February 13, 2006. S. Mercadante (1998). "Oral morphine consumption in Italy and Sicily". Journal of Pain and Symptom Management. 15 (4): 227–30. doi: 10.1016/S0885-3924(98)00368-6. PMID 9601157. a b c d e Brown Richard Harvey (2002). "The Opium Trade And Opium Policies In India, China, Britain, And The United States: Historical Comparisons And Theoretical Interpretations". Asian Journal of Social Science. 30 (3): 623. doi: 10.1163/156853102320945420. The production methods have not significantly changed since ancient times. Through selective breeding of the Papaver somniferum plant, the content of the phenanthrene alkaloids morphine, codeine, and to a lesser extent thebaine has been greatly increased. In modern times, much of the thebaine, which often serves as the raw material for the synthesis for oxycodone, hydrocodone, hydromorphone, and other semisynthetic opiates, originates from extracting Papaver orientale or Papaver bracteatum. As the power of the Roman Empire declined, the lands to the south and east of the Mediterranean Sea became incorporated into the Islamic Empires. Some Muslims believe hadiths, such as in Sahih Bukhari, prohibits every intoxicating substance, though the use of intoxicants in medicine has been widely permitted by scholars. [16] Dioscorides' five-volume De Materia Medica, the precursor of pharmacopoeias, remained in use (which was edited and improved in the Arabic versions [17]) from the 1st to 16th centuries, and described opium and the wide range of its uses prevalent in the ancient world. [18]The first known cultivation of opium poppies was in Mesopotamia, approximately 3400 BCE, by Sumerians, who called the plant hul gil, the "joy plant". [11] [12] Tablets found at Nippur, a Sumerian spiritual center south of Baghdad, described the collection of poppy juice in the morning and its use in production of opium. [1] Cultivation continued in the Middle East by the Assyrians, who also collected poppy juice in the morning after scoring the pods with an iron scoop; they called the juice aratpa-pal, possibly the root of Papaver. [13] Opium production continued under the Babylonians and Egyptians. Hubble D (October 1957). "Opium Addiction and English Literature". Medical History. 1 (4): 323–35. doi: 10.1017/s0025727300021505. PMC 1034310. PMID 13476921. Globally, opium has gradually been superseded by a variety of purified, semi-synthetic, and synthetic opioids with progressively stronger effects, and by other general anesthetics. This process began in 1804, when Friedrich Wilhelm Adam Sertürner first isolated morphine from the opium poppy. [100] [101] Modern vial of morphine first isolated from opium by Friedrich Sertürner Jennifer Hull (June 24, 2001). "Eastern Europe Shooting Up Under A Red Star". Time . Retrieved April 17, 2020.