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MyProtein Creatine Monohydrate,Powder - 1KG

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Casey A, et al. Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Am J Physiol. 1996;271(1 Pt 1):E31–7. With regard to the question of whether creatine has effect on renal function, a few case studies [ 249, 250, 251, 252] reported that individuals purportedly taking creatine with or without other supplements presented with high creatinine levels and/or renal dysfunction [ 249, 250, 251]. Additionally, one study suggested that feeding rats with renal cystic disease 2 g/kg/d of creatine for 1 week (equivalent to 140 g/day for a 70 kg individual) and 0.4 g/kg/d (equivalent to 28 g/day for a 70 kg individual) for 4 weeks exacerbated disease progression. These reports prompted some concern that creatine supplementation may impair renal function [ 253, 254, 255, 256] and prompted a number of researchers to examine the impact of creatine supplementation on renal function [ 22, 51, 85, 114, 156, 172, 243, 244, 245, 246, 247, 248, 257, 258, 259]. For example, Ferreira and associates [ 260] reported that creatine feeding (2 g/kg/d for 10 weeks equivalent to 140 g/kg/d in a 70 kg person) had no effects on glomerular filtration rate and renal plasma flow in Wistar rats. Likewise, Baracho and colleagues [ 261] reported that Wistar rats fed 0, 0.5, 1, or 2 g/kg/d of creatine did not result in renal and/or hepatic toxicity. Poortmans and coworkers reported that ingesting 20 g/day of creatine for 5 days [ 243], and up to 10 g/day from 10 months to 5 years [ 257] had no effect on creatine clearance, glomerular filtration rate, tubular resorption, or glomerular membrane permeability compared to controls. Kreider et al. [ 22] reported that creatine supplementation (5–10 g/day for 21 months) had no significant effects on creatinine or creatinine clearance in American football players. Gualono and associates [ 262] reported that 12 weeks of creatine supplementation had no effects on kidney function in type 2 diabetic patients. Finally, creatine supplement has been used as a means of reducing homocysteine levels and/or improving patient outcomes in patients with renal disease [ 263, 264, 265] as well as ameliorating birth asphyxia related renal dysfunction in mice [ 228]. Moreover, long-term, high dose ingestion of creatine (up to 30 g/d for up to 5 years) in patient populations has not been associated with an increased incidence of renal dysfunction [ 23, 155, 156, 172]. While some have suggested that individuals with pre-existing renal disease consult with their physician prior to creatine supplementation in an abundance of caution, these studies and others have led researchers to conclude that there is no compelling evidence that creatine supplementation negatively affects renal function in healthy or clinical populations [ 5, 6, 22, 53, 259, 266, 267]. Creatine Monohydrate from Protein Works is made with only the finest Creatine available. Used by elite athletes and teams, Creatine Monohydrate is proven to help improve physical performance. Roitman S, et al. Creatine monohydrate in resistant depression: a preliminary study. Bipolar Disord. 2007;9(7):754–8. Poortmans JR, et al. Effect of short-term creatine supplementation on renal responses in men. Eur J Appl Physiol Occup Physiol. 1997;76(6):566–7.

creatine Common questions and misconceptions about creatine

Kreider RB, Jung YP. Creatine supplementation in exercise, sport, and medicine. J Exerc Nutr Biochem. 2011;15(2):53–69. Gualano B, et al. Creatine supplementation in the aging population: effects on skeletal muscle, bone and brain. Amino Acids. 2016;48(8):1793–805. Braissant O. Creatine and guanidinoacetate transport at blood–brain and blood-cerebrospinal fluid barriers. J Inherit Metab Dis. 2012;35(4):655–64. Creatine supplementation can help athletes recover from intense training. For example, Green and coworkers [ 8] reported that co-ingesting creatine (5 g) with large amounts of glucose (95 g) enhanced creatine and carbohydrate storage in muscle. Additionally, Steenge et al. [ 49] reported that co-ingesting creatine (5 g) with 47–97 g of carbohydrate and 50 g of protein enhanced creatine retention. Nelson and colleagues [ 104] reported that creatine loading prior to performing an exhaustive exercise bout and glycogen loading promoted greater glycogen restoration than just carbohydrate loading alone. Since glycogen replenishment is important to promoting recovery and preventing overtraining during intensified training periods [ 78], creatine supplementation may help athletes who deplete large amounts of glycogen during training and/or performance to maintain optimal glycogen levels. Howard AN, Harris RC. Compositions containing creatine, U.S.P. Office, Editor. United States: United States Patent Office, United States Government; 1999.A number of studies have investigated the short and long-term therapeutic benefit of creatine supplementation in children and adults with various neuromuscular diseases like muscular dystrophies [ 160, 161, 162, 163, 164, 165], Huntington’s disease [ 23, 166, 167, 168, 169, 170, 171]; Parkinson disease [ 23, 40, 166, 172, 173, 174]; mitochondria-related diseases [ 29, 175, 176, 177]; and, amyotrophic lateral sclerosis or Lou Gehrig’s Disease [ 166, 178, 179, 180, 181, 182, 183, 184]. These studies have provided some evidence that creatine supplementation may improve exercise capacity and/or clinical outcomes in these patient populations. However, Bender and colleagues [ 23] recently reported results of several large clinical trials evaluating the effects of creatine supplementation in patients with Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). A total of 1,687 patients took an average of 9.5 g/day of creatine for a total of 5,480 patient years. Results revealed no clinical benefit on patient outcomes in patients with PD or ALS. However, there was some evidence that creatine supplementation slowed down progression of brain atrophy in patients with HD (although clinical markers were unaffected). Whether creatine supplementation may have a role in mediating other clinical markers in these patient populations and/or whether individual patients may respond more positively to creatine supplementation than others, remain to be determined. Nevertheless, these studies show that creatine supplementation has been used to treat children and adults with neurodegenerative conditions and is apparently safe and well-tolerated when taking up to 30 g/day for 5 years in these populations. Ischemic heart disease Galvan E, et al. Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance. J Int Soc Sports Nutr. 2016;13:12. Andreassen OA, et al. Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington’s disease. Neurobiol Dis. 2001;8(3):479–91.

Creatine Monohydrate Micronized Powder (1 KG Nutricost Creatine Monohydrate Micronized Powder (1 KG

Kreider RB, et al. ISSN exercise & sport nutrition review: research & recommendations. J Int Soc Sports Nutr. 2010;7:7.Easton C, Turner S, Pitsiladis YP. Creatine and glycerol hyperhydration in trained subjects before exercise in the heat. Int J Sport Nutr Exerc Metab. 2007;17(1):70–91. Boudina S, et al. Alteration of mitochondrial function in a model of chronic ischemia in vivo in rat heart. Am J Physiol Heart Circ Physiol. 2002;282(3):H821–31. Creatine monohydrate is the most effective ergogenic nutritional supplement currently available to athletes with the intent of increasing high-intensity exercise capacity and lean body mass during training.

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